Pregnancy depends on a delicate balance of immune activation and regulation

It is well recognized that immune tolerance is important to prevent semiallografted fetuses from rejection by maternal immunocompetent cells; however, immune activation also plays an important role in placental development and fetal growth. Basic and clinical studies have shown that an imbalance between immune activation and regulation can lead to implantation failure, miscarriage, and preeclampsia. Here, the balance between immunostimulation and immunoregulation in reproduction will be reviewed.

Traduire les albums pour enfants d’Hervé Tullet en polonais

This paper concentrates on the translation of the text-image interaction in postmodern and multimodalpic turebooks for children, as illustrated by the Polish translations of Hervé Tullet’s picturebooks. The sophisticated and artistic vision of this author-illustrator raises questions about methods and criteria to be adopted by anyone who wishes to translate the delicate balance between what is told by the verbal and pictured by the visual. In particular, as the present analysis reveals, the translator’s interventions in the original text-image interaction cannot be regarded as intersemiotic translation, but as undesired explicitation limiting the creative actions of the active child-reader.

Strangers in the dark: Navigating opacity and transparency in open online career-related knowledge sharing

Given repeated upheavals in jobs and organizations, people increasingly share career-related knowledge in open online platforms. Dealing with career-related knowledge in an open online setting, though, is challenging. It requires people to balance between exchanging too much and too little career-related knowledge, e.g., to disclose and share the right knowledge without jeopardizing themselves. This study examines how participants achieve such delicate balance in open online processes. It investigates discussions in a career advice-focused online platform. Findings reveal how open online career-related exchanges include sequences of knowledge sharing, knowledge evaluating, and of diverting. They also include sequences of regulating openness that involve securing opacity for the people participating while also ensuring the transparency of the process. The study unpacks how participants in an open online setting navigate the dynamic balance between individual opacity and processual transparency. Findings hold implications for scholarship on open organizing, careers, and advice networks, as well as for practice.

Three principles for writing an effective qualitative results section

Writing an effective qualitative results section can be a daunting task. How do you report the findings of the study and tell a compelling story? It is this delicate balance that we strive to navigate in this paper. We offer three principles—storytelling, authenticity and argument—to help writers envision the story they will tell, select the data as evidence for that story and integrate quotations to guide the reader’s interpretation. Practical advice and concrete illustrations make the principles easy to apply to your own writing. Finally, by reflecting on how historical, methodological and disciplinary elements shape their application, you will be able to use these principles to enhance the persuasiveness of your qualitative results section.

A COMPARATIVE STUDY OF PERITONITIS ASSOCIATED HYPERLACTAMIA FOR EVALUATING MORTALITY IN SECONDARY PERITONITIS

Lactate levels are normally maintained at less than 1.5 mmol/L using a delicate balance between production and clearance (by liver and kidneys). Hyperlactemia has shown correlation with higher mortality. In our study on 30 indoor patients of perforation peritonitis in SMS medical college, Jaipur – we found that higher lactate level (> 4) is associated with higher ventilator need (80%) and hence higher mortality (60%). Keywords: Hyperlactemia.

”och mymlan flög / och mjölken for”

The Child Readers and Poetry in Tove Jansson’s Picturebook The Book about Moomin, Mymble and Little My Abstract: Tove Jansson’s picturebook Hur gick det sen? Boken om Mymlan, Mumintrollet och lilla My (The Book about Moomin, Mymble and Little My) from 1952 is a book which makes use of its material aspects in many regards, employing the interactivity of the picturebook format to its maximum. Given the fact that it is written in verse, and is considered a classic by all means, it is surprising to find that the function that poetry plays within the book has been scarcely explored in prior research. By examining how the format of this particular picturebook guides the manner in which the child reader experiences it, and by studying the function of poetry within that framework, the article shows that poetry potentially plays a vital role in how child readers make sense of it. In particular, the role of poetry manifests itself as an opportunity for child readers to – at their own pace, and in their own manner – deal with the delicate balance between the attachmentseeking struggles of the anxious character of Moomin, on the one hand, and the exploratory individuation of the adventurous character of Little My, on the other. Through these examinations, the article demonstrates how the use of poetry can facilitate an emancipatory opportunity for child readers within picturebooks – and how this potential is ever-present within the format and the reading situation of picturebooks for children in general.

Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain VHH antibodies

The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain VHH antibodies exhibit high specificity and affinity but have higher stability and solubility than conventional antibodies as they are single-domain proteins. In this work, based on physicochemical measurements and molecular dynamics (MD) simulations, we have gained insight that will facilitate rational design of single-chain VHH antibodies. We first assessed two homologous VHH antibodies by differential scanning calorimetry (DSC); one had a high (64.8 °C) and the other a low (58.6 °C) melting temperature. We then generated a series of the variants of the low stability antibody and analyzed their thermal stabilities by DSC and characterized their structures through MD simulations. We found that a single mutation that resulted in 8.2 °C improvement in melting temperature resulted in binding affinity an order of magnitude lower than the parent antibody, likely due to a shift of conformational space explored by the single-chain VHH antibody. These results suggest that the delicate balance among conformational stability, binding capability, and conformational space explored by antibodies must be considered in design of fully functional single-chain VHH antibodies.