An initial ‘snapshot’ of sensory information biases the likelihood and speed of subsequent changes of mind

We often need to rapidly change our mind about perceptual decisions in order to account for new information and correct mistakes. One fundamental, unresolved question is whether information processed prior to a decision being made (‘pre-decisional information’) has any influence on the likelihood and speed with which that decision is reversed. We investigated this using a luminance discrimination task in which participants indicated which of two flickering greyscale squares was brightest. Following an initial decision, the stimuli briefly remained on screen, and participants could change their response. Using psychophysical reverse correlation, we examined how moment-to-moment fluctuations in stimulus luminance affected participants’ decisions. This revealed that the strength of even the very earliest (pre-decisional) evidence was associated with the likelihood and speed of later changes of mind. To account for this effect, we propose an extended diffusion model in which an initial ‘snapshot’ of sensory information biases ongoing evidence accumulation.

The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication

How distal cis-regulatory elements (e.g., enhancers) communicate with promoters remains an unresolved question of fundamental importance. Although transcription factors and cofactors are known to mediate this communication, the mechanism by which diffusible molecules relay regulatory information from one position to another along the chromosome is a biophysical puzzle—one that needs to be revisited in light of recent data that cannot easily fit into previous solutions. Here we propose a new model that diverges from the textbook enhancer–promoter looping paradigm and offer a synthesis of the literature to make a case for its plausibility, focusing on the coactivator p300.

Camera realignment imposes a cost on laparoscopic performance

There is an unresolved question about whether realigned visual feedback is beneficial or costly to laparoscopic task performance. We provide evidence that camera realignment imposes a reliable cost on performance across both naive controls and experienced surgeons. This finding clarifies an important ongoing discussion in the literature about the effects of camera realignment, which could inform the strategies that laparoscopic surgeons use in the operating room.

Structure, Bioactivity and Analytical Methods for the Determination of Yucca Saponins

Yucca is one of the main sources of steroidal saponins, hence different extracts are commercialized for use as surfactant additives by beverage, animal feed, cosmetics or agricultural products. For a deeper understanding of the potential of the saponins that can be found in this genus, an exhaustive review of the structural characteristics, bioactivities and analytical methods that can be used with these compounds has been carried out, since there are no recent reviews on the matter. Thus, a total of 108 saponins from eight species of the genus Yucca have been described. Out of these, the bioactivity of 68 saponins derived from the isolation of Yucca or other genera has been evaluated. Regarding the evaluation and quality control of the saponins from this genus LC-MS technique is the most often used. Nevertheless, the development of methods for their routine analysis in commercial preparations are needed. Moreover, most of the studies found in the literature have been carried out on Y. schidigera extract, since is the most often used for commercial purposes. Only eight of the 50 species that belong to this genus have been studied, which clearly indicates that the identification of saponins present in Yucca genus is still an unresolved question.

Hierarchies, Knowledge, and Power Inside Organizations

This paper contributes to an old and still unresolved question in the theory of organizations, namely, what do bosses do? Whether and to what extent managerial functions are productive or not for the well functioning of an organization has to be understood with respect to the tension between knowledge and power. Here, we start addressing such a tension with reference to the very nature of organizations. Next, we discuss its historical unfolding in two archetypical organizational modes of production, Taylorism and Toyotism. Third, these two archetypical configurations are studied by means of a model of organizations populated by three sets of agents, workers, managers, and the principal, endowed by different attributes and functions. The fitness of alternative organizational setups is studied under diverse degrees of complexity of the landscape.

The Liturgical Communion of the Yaḥad with the Angels

Since the discoveries of the first Dead Sea Scrolls, the motif of a communion with the angels has been repeatedly emphasized and discussed as a characteristic of the self-understanding of the community behind these writings. Of particular interest in this discussion are the Songs of the Sabbath Sacrifice (4Q400–407; 11Q17; and Mas1k ShirShabb). However, the origin of the so-called Angelic Liturgy is still an unresolved question in scholarship. In this article we will try to figure out the relationship of the Songs of the Sabbath Sacrifice to the sectarian literature by analyzing the communion with the angels described therein. I will demonstrate that this composition has the most explicit connections to the liturgical communion with the angels that is uniquely found in undisputed sectarian texts. The Angelic Liturgy is then not so much the source, but much more an example of the liturgical development inside the yaḥad.