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Diabetes ◽  
2017 ◽  
Vol 67 (3) ◽  
pp. 486-495 ◽  
Author(s):  
Young-Beom Kim ◽  
Woong Bin Kim ◽  
Won Woo Jung ◽  
Xiangyan Jin ◽  
Yoon Sik Kim ◽  
...  

2017 ◽  
Vol 313 (2) ◽  
pp. F450-F460 ◽  
Author(s):  
Regiane Cardoso Castelo-Branco ◽  
Deise C. A. Leite-Dellova ◽  
Fernanda Barrinha Fernandes ◽  
Gerhard Malnic ◽  
Margarida de Mello-Aires

The acute effects of angiotensin-1–7 [ANG-(1–7)] on the reabsorptive bicarbonate flow (J[Formula: see text]) were evaluated using stationary microperfusion in vivo in the proximal tubules of spontaneously hypertensive rats (SHR) and their normotensive controls, Wistar-Kyoto (WKY) rats, using a microelectrode sensitive to H+. In WKY rats, the control J[Formula: see text] was 2.40 ± 0.10 nmol·cm−2·s−1 ( n = 120); losartan (10−7 M) or A779 (10−6 M, a specific Mas antagonist), alone or in combination with losartan, decreased the J[Formula: see text]. ANG-(1–7) had biphasic effects on J[Formula: see text]: at 10−9 M, it inhibited, and at 10−6, it stimulated the flow. S3226 [10−6 M, a specific Na+-H+ exchanger 3 (NHE3) antagonist] decreased J[Formula: see text] and changed the stimulatory effect of ANG-(1–7) to an inhibitory one but did not alter the inhibitory action of ANG-(1–7). In SHR, the control J[Formula: see text] was 2.04 ± 0.13 nmol·cm−2·s−1 ( n = 56), and A779 and/or losartan reduced the flow. ANG-(1–7) at 10−9 M increased J[Formula: see text], and ANG-(1–7) at 10−6 M reduced it. The effects of A779, losartan, and S3226 on the J[Formula: see text] were similar to those found in WKY rats, which indicated that in SHR, the ANG-(1–7) action on the NHE3 was via Mas and ANG II type 1. The cytosolic calcium in the WKY or SHR rats was ~100 nM and was increased by ANG-(1–7) at 10−9 or 10−6 M. In hypertensive animals, a high plasma level of ANG-(1–7) inhibited NHE3 in the proximal tubule, which mitigated the hypertension caused by the high plasma level of ANG II.


EP Europace ◽  
2016 ◽  
Vol 18 (11) ◽  
pp. 1711-1718 ◽  
Author(s):  
Pil-Sung Yang ◽  
Tae-hoon Kim ◽  
Jae-Sun Uhm ◽  
Sungha Park ◽  
Boyoung Joung ◽  
...  

2016 ◽  
Vol 78 (3) ◽  
pp. 243-247
Author(s):  
Chiaki KIYONAGA ◽  
Mitsuhiro MATSUDA ◽  
Kazuhiro YOSHIMURA ◽  
Chika OHATA ◽  
Minao FURUMURA ◽  
...  

2015 ◽  
Vol 53 (3) ◽  
pp. 249-258 ◽  
Author(s):  
Katarzyna Piotrowska ◽  
Sylwia Sluczanowska-Glabowska ◽  
Magda Kucia ◽  
Andrzej Bartke ◽  
Maria Laszczynska ◽  
...  

Hepatology ◽  
2012 ◽  
Vol 56 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Caroline Scholtes ◽  
Christophe Ramière ◽  
Dominique Rainteau ◽  
Laure Perrin-Cocon ◽  
Claude Wolf ◽  
...  

2012 ◽  
Vol 28 (9) ◽  
pp. 722-725 ◽  
Author(s):  
Aydogan Aydogdu ◽  
Ilker Tasci ◽  
Serkan Tapan ◽  
Yalcin Basaran ◽  
Umit Aydogan ◽  
...  

Diabetes Care ◽  
2011 ◽  
Vol 34 (9) ◽  
pp. 2113-2115 ◽  
Author(s):  
Cheng Chen ◽  
Bernard M.Y. Cheung ◽  
Annette W.K. Tso ◽  
Yudong Wang ◽  
Lawrence S.C. Law ◽  
...  

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