Synergic effect of aqueous extracts of Ocimum sanctum and Trigonella foenum-graecum L on the in situ green synthesis of silver nanoparticles and as a preventative agent against antibiotic-resistant food spoiling organisms

Combining Ocimum sanctum and Trigonella foenum-graecum L leaf water extracts synergistically act as a reducing and capping agent for the synthesis of narrow polydisperse silver nanoparticles with controlled sizes depending on the precursor (AgNO3) concentration.

Pharmacological aspects & medicinal uses of Trigonella foenum-graecum: A Current Review

Globally a large number of people are affected by acute and chronic diseases resulting in high morbidity and mortality rate. A huge amount of pharmaceutical drugs are being manufactured on a daily basis to combat these diseases. But due to their high cost and deleterious effects, it becomes critically important to state emphasis on finding an alternative way to manage these long term conditions. Medicinal herbs could provide a good source of dietary supplement combined with existing therapies. Many scientific studies have demonstrated that medicinal plants and herbs have the potential for the treatment of many serious infections and many disorders. Out of these herbs, Fenugreek is recognized as an oldest herb with great medicinal potential. Fenugreek harbors many essential macronutrients and micronutrients along with trace elements. Numerous chemical constituents present in fenugreek highlights a variety of pharmacological activity such as anti-glycemic activity, anti-oxidant capacity, anti-inflammatory effects, hypocholesterolemic activity and many more. This article explores the diverse active compounds and potential pharmacological applications of Trigonella foenum-graecum also known as fenugreek. It also focuses on the medicinal significance and health impact of taking fenugreek in our day to day nutrition.

Fenugreek Seed

Fenugreek (Trigonella foenum graecum), native to southern Europe and Asia, is anannual herb with white flowers and hard, yellowish brown and angular seeds,known from ancient times, for nutritional value beside of it medicinal effects. Fenugreek seeds are rich source of gum, fiber, alkaloid, flavonoids, saponin and volatile content. Due to it's high content of fiber, fenugreek could be used as food stabilizer, adhesive and emulsifying agent to change food texture for some special purposes. Some evidences suggest that fenugreek may also be regarded as antidiabetic, anticarcinogenic, remedy for hypocholesterolemia and hypoglycemia, antioxidant, antibacterial agent, gastric stimulant, and anti-anorexia agent. The present article is aimed to review the potential applications of fenugreek as a functional food and nutraceutical. Keywords: Chemical composition, Fenugreek gum, Fenugreek, Health benefits

An assessment of cytotoxic potentiality of Aloe barbadensis on the root meristem cells of Trigonella foenum-graecum L.

The leaves of Aloe barbadensis are used in traditional and modern systems of medicine. The aim of this study was to evaluate the cytotoxic potentialities of aqueous solution of Aloe barbadensis leaves on Trigonella foenum-graecum root tip meristem cells using a cytogenetic approach. Treatments with various concentrations of Aloe barbadensis leaf extract to Trigonella foenum-graecum root meristem cells showed mito-inhibition and induced several chromosomal aberrations as chromsomal breakage, fragmentation, scattering, stickiness etc.

Effect of Ethanol Solvents on Total Phenolic Content and Antioxidant Properties of Seed Extracts of Fenugreek (Trigonella foenum-graecum L.) Varieties and Determination of Phenolic Composition by HPLC-ESI-MS

Fenugreek (Trigonella foenum-graecum L.) is one of the oldest cultivated plants grown for its leaves and seeds that are used for both culinary and medicinal purpose. This study aims to evaluate the effect of ethanol concentration (30, 50, 70 and 96% (v/v) of ethanol in water) as a solvent for the extraction of total phenolic content (TPC) and antioxidant properties (antiradical activity (ARA), transition metal reducing power (TMRP), iron chelating ability (ICA)) of seed extracts of spring variety Ovari 4 (FSV) and winter variety PSZ.G.SZ (FWV) fenugreek, and separate and identify the major phenolics of the extracts by HPLC-ESI-MS. The results indicated that 70% ethanol solution resulted in the maximum amount of TPC for both FSV and FWV seeds. The TPC decreased in the treatments in the following order: 70% ethanol > 96% ethanol > 50% ethanol > 30% ethanol, whereas extraction yield changed in a different manner: 30% ethanol > 50% ethanol > 70% ethanol > 96% ethanol. The extracts from seeds of both fenugreek varieties obtained with 70% and 96% ethanol showed equal high RSA while superior TMRP and ICA were observed in 70% ethanol extracts. The TMRP and ICA were strongly correlated with TPC for both varieties. The correlation between RSA and TPC was high, but not significant. Thus, the obtained data indicate the 70% ethanol solvent suitability for efficient extraction of phenolic compounds from seeds of the FWV and FSV. According to an HPLC-ESI-MS analysis, the polyphenolic profiles of fenugreek are presumably formed by flavone C-glycosides with apigenin or luteolin as aglycone linked with different glycones. High antioxidant activity of FWV seeds can be an adaptation to cold stress of the winter variety aimed at strengthening the antioxidant defense of the germinating seeds.