Sublingual misoprostol to reduce blood loss at caesarean delivery

Background: Caesarean section is the most common obstetrical procedure performed worldwide. Sometimes oxytocin alone is not sufficient to prevent postpartum haemorrhage and additional uterotonics may be required. We attempted an additional uterotonic misoprostol by sublingual route to evaluate the role of it to reduce blood loss at caesarean delivery.Methods: This prospective clinical study was done on patients of S. S. G. Hospital, Baroda; 138 patients who underwent lower segment caesarean section (elective or emergency). The primary outcome was less intra/peri operative blood loss, need for additional uterotonic agents and perioperative haemoglobin (Hb) fall. The secondary outcomes studied were incidence of shivering, pyrexia, nausea, vomiting, operating time, blood transfusion, endomyometritis and hospitalization period. Average blood loss after normal vaginal delivery is 500 ml and after caesarean delivery is around 1000 ml.Results: Mean postoperative Hb was high with misoprostol group and perioperative Hb fall was less. Perioperative Hb fall of 1 g or more was lesser in this group.Conclusions: Sublingual misoprostol reduces intraoperative blood loss, perioperative blood loss and the need for additional uterotonic agents and blood transfusions at caesarean delivery.

Puerperal complications in elective versus emergency caesarean deliveries

Background: The aim of current study was to compare puerperal complications in elective vs emergency caesarean section. Though similar complications occur in elective and emergency caesarean sections, this study aims to find out which complications are more common in either of them.Methods: A prospective case comparative study was conducted at GCS Medical College and Hospital, Department of Obstetrics and Gynecology, Ahmedabad from 01 December 2020 to 01 June 2021.Results: The emergency caesarean section (CS) rates (36) were more common in the age group of 21-25 years than the elective CS (32). Emergency CS was most common in primipara women (69). The most common risk factor is previous known history of hypothyroidism and most common indication is known history of previous lower segment caesarean section (LSCS). 10 patients in elective CS and 8 patients in emergency CS had previous LSCS. Body mass index (BMI) of 26 patients in elective CS was ranging between 24.9-29.9 kg/m2 when compared to 28 patients with similar BMI in emergency CS. Overweight patients underwent more emergency CS when compared to elective CS. Most common intra-operative complication was adhesions between rectus sheath and muscle and second most common was dense adhesion. Most common post op complication was breast engorgement and mastitis.Conclusions: There is a significant difference between the number of patients in elective and emergency CS group when common indications are seen (p<0.05). Similarly, statistically significant is observed between the 2 groups when post-operative complications are observed (p<0.05).

A Case Report: A 37 Years-old Women with Takayasu Arteritis

Background: A rarity of form of vasculitis, also known as TAK, induces inflammation in the walls of the major arteries in the body: the aorta and its main branches. The disease results from a body attack and inflammation of the walls of the arteries caused by the body's own immune system. Case Presentation: A 37-years-old women had complaints of fever, giddiness, weakness of right upper limb and lower limb since1 day. After undergoing whole blood count, liver function examination, renal and MRI function checks, CT scan, angiography, etc. was studied. She was diagnosed with takayasu arteritis. She had past medical history of neck pain and numbness since January 2020. For these complaints her family members referred her in private hospital. There is no significant history of surgery in present, lower segment caesarean section and piles operation was done previously. Physical findings were normal except the Glasgow Coma Scale score was 11 that is, patient was semi-conscious, In General appearance patient activity was dull and weak due disease condition, Patient’s all routine investigations were normal except few like Total WBC count was increased (21,500cell /cm) due to increased infection, Granulocytes were increased that is 75 % due to infection and autoimmune disease, ESR was increased that is52mm/h. Angiography showed block in the right common carotid artery, MRI- showed Acute infract in left fronto temporo parietal region involving insular par ventricular white matter, absent flow in distal M1 segment of MCA. Conclusion: The most frequently involved arteries and the angiographic trends in this Takayasu Arteritis study were subclavian arteries and carotid arteries. The difference between angiographic characteristics may lead to clinical differences. Operations and surgery should be carried out at various points in the course of the disease.

Incidence and indications of LSCS among Doctors Community of Chattogram

Background: Lower segment caesarean section (LSCS) is a surgical intervention, which is carried out to ensure the safety of mother and baby when vaginal delivery is not possible or when danger to mother and baby would be greater with vaginal delivery. This study is designed to identify indication of LSCS and detect complications if any among the respondents. Materials and methods: Cross sectional descriptive study where 95 female doctors of Chattogram were selected by convenient sampling without knowing their mode of delivery and if it is LSCS then indication of LSCS , maternal and neonatal complications were noted. Results: Age of the respondents at the time of interview were noted and most of them were between 31- 40 years 52 (55%), regarding income most of them between 100000 -200000 42(44%) most of the delivery occurred in the private clinics 92 (70%) regarding mode of delivery, LSCS was 92 (70%) vaginal delivery 40 (30%) regarding indications of LSCS most common was repeat caesarean section 27 (29%) and second common was LSCS due to maternal interest 18 (20%) and others were severe preeclampsia 10 (11%) fetal distress 08(09%) placenta previa, Diabetes with big baby, cephalopelvic disproportion, PROM with non progression of labour. PPH was the most common complication 05 (63%), next was paralytic ileus 02 (25%) and left ventricular failure 01 (12%). Common neonatal comoplications were low birth weight baby 904 (40%), prematurity 03 (30%) and birth asphyxia 03 (03%). Conclusion: LSCS is a major surgical procedure for delivery. Inspite of its low maternal morbidity and mortality due to improved surgical technique, modern aneasthetic skill and availability of blood and blood products, still it carries a slightly greater risk in subsequent pregnancy, so we should be rational in doing primary caesarean section. Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 37-40

Caesarean scar endometriosis

Endometriosis is defined by the presence and growth of ectopic functional endometrial tissue outside the uterus. The symptoms are nonspecific, typically involving abdominal wall pain at the time of menstruation. It commonly follows obstetrical and gynecological surgeries. The diagnosis is frequently made only after excision of scar the diseased tissue. A case report of 34 year old female patient presenting with scar endometriosis 7 years after her last LSCS (lower segment caesarean section). The patient came with the complaint of supra pubic swelling since 6 months, which was growing slowly. Her menstrual history was regular, but she had lower abdominal pain during menstruation. On clinical history, examination and USG finding the swelling was diagnosed as scar endometriosis.

A STUDY OF DEMOGRAPHIC AND RISK FACTORS OF CHILDREN WITH AUTISM SPECTRUM DISORDER

Background of the study: Various risk factors have been reported in the development of Autism spectrum Disorder. The aim of our study is to explore the demographic and perinatal risk factors implicated in the development of ASD. A retrospective study was conducted with data of 49 children with ASD and found that total 71.3% of children were male 73.5% were in rst birth order. Out of 49 children 53.1% had history of Lower Segment Caesarean Section (LSCS). Indication of LSCS due to various obstetric or perinatal risk factors were reported in 17 cases. Three children had history of low birth weight with history of admission into Neonatal ICU. The study also explore the various co morbidity and found that ADHD (20.4%) was most common comorbidity followed by Mental retardation(18.4%), ADHD and MR(12.2%), seizure disorder and MR (8.2 %). This study found that male gender, rst birth order and perinatal risk factors are implicated in the development of Autism spectrum Disorder and majority of them have one or more another neuro developmental disorder as a comorbidity.

Transversus abdominis plane block by landmark technique with ropivacaine versus bupivacaine for post-operative analgesia in patients undergoing lower segment caesarean section deliveries

Transversus Abdominis Plane (TAP) Block is an efficacious abdominal field block which is widely used component of multimodal analgesia. Compare the efficacy of Inj. Ropivacaine 0.2% and Inj. Bupivacaine 0.2% when used in TAP block for post-operative analgesia in lower segment caesarean section deliveries(LSCS) done under spinal anaesthesia. Randomized double blinded prospective study conducted after institutional ethics committee in our institute. We have recruited sixty patients scheduled for an elective LSCS which were enrolled into two groups to receive TAP block with bupivacaine 0.2% 15ml Group B (n=30) versus ropivacaine 0.2% 15ml Group R (n=30) + dexamethasone 2mg bilaterally. TAP block was administered on completion of surgery. Primary objective was to compare time to rescue analgesia in postoperative period. Secondary Objectives wereto compare hemodynamic response during postoperative period, measure the intensity of pain using visual analogue scale (VAS), number of analgesic doses in first 24 hours, patient satisfaction with pain management and complications if any.SPSS software 16 version. Time for rescue analgesia was shorter in Group B (6.7 hour) than in Group R (9.47 hour) (p = 0.00). VAS was lower in Group R. Higher dose of analgesics was required in Group B (p=0.008). All this led to higher patient satisfaction score in Group R. This study concludes that 0.2% ropivacaine provided a longer duration of analgesia compared to 0.2% bupivacaine when used in TAP block for post-operative analgesia in LSCS deliveries.