cinnamic aldehyde
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2022 ◽  
Vol 8 ◽  
Author(s):  
You Wu ◽  
Ming-hui Wang ◽  
Tao Yang ◽  
Tian-yu Qin ◽  
Ling-ling Qin ◽  
...  

Cinnamic acid (AC) and cinnamic aldehyde (AL) are two chemicals enriched in cinnamon and have been previously proved to improve glucolipid metabolism, thus ameliorating metabolic disorders. In this study, we employed transcriptomes and proteomes on AC and AL treated db/db mice in order to explore the underlying mechanisms for their effects. Db/db mice were divided into three groups: the control group, AC group and AL group. Gender- and age-matched wt/wt mice were used as a normal group. After 4 weeks of treatments, mice were sacrificed, and liver tissues were used for further analyses. Functional enrichment of differentially expressed genes (DEGs) and differentially expressed proteins (DEPs) were performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. DEPs were further verified by parallel reaction monitoring (PRM). The results suggested that AC and AL share similar mechanisms, and they may improve glucolipid metabolism by improving mitochondrial functions, decreasing serotonin contents and upregulating autophagy mediated lipid clearance. This study provides an insight into the molecular mechanisms of AC and AL on hepatic transcriptomes and proteomes in disrupted metabolic situations and lays a foundation for future experiments.


2021 ◽  
pp. 112716
Author(s):  
A.M. Api ◽  
D. Belsito ◽  
D. Botelho ◽  
M. Bruze ◽  
G.A. Burton ◽  
...  

2021 ◽  
Vol 17 ◽  
Author(s):  
Bambang Susilo ◽  
Abd. Rohim ◽  
Midia Lestari W. H.

Background: S. cristaefolium is the brown seaweed extracted using the serial technique with different solvents. Methods: S. cristaefolium powder (50 mesh) was extracted with hexane, ethyl acetate, and methanol respectively. The S. cristaefolium powder residue had been dried before being re-extracted with the next different solvents. Three serial extracts were obtained and named as the 1-stage extract, 2-stage extract, and 3-stage extract. Besides, a single-step extract (extraction using only methanol) was also produced to compare with three serial extracts in antibacterial activity tests (against E. coli and S. aureus). The three serial extracts were detected their antibacterial compounds using GC-MS, LC-HRMS, and FT-IR. Results: The 3-stage extract had the highest extraction yield. On S. aureus, the inhibition zone in all extracts was not significantly different. On E.coli, the highest inhibition zone (5.42±0.14 mm) was the 3-stage extract, indeed it is higher than both antibiotic and a single-step extract. Phenol, 9-Tricosene(Z)-, palmitic acid, and oleamide were contained in all extracts. Other antibacterial compound types, both the 1-stage and 2-stage extracts contained 8 types whilst the 3-stage extract contained the most types (12 types). Particularly, hexyl cinnamic aldehyde and betaine were detected only in the 3-stage extract with the dominant area. The carboxylic acid groups were detected in all extracts to confirm the fatty acid structure. Several cinnamic aldehyde groups were detected only in the 3-stage extract. Conclusions: Thus, the extraction technique serially could produce the 3-stage extract which has the strongest antibacterial activity and the richest antibacterial compounds.


Author(s):  
M. González ◽  
D. Loroña ◽  
L. Condolo ◽  
M. Almeida

This study proposes the use of cinnamon as an antimicrobial agent with the presence of cinnamic aldehyde, which has antibacterial and antifungal activity and inhibits the production of mycotoxins. Initially, microorganisms were isolated in damaged post-harvest strawberries, isolating colonies of Botritys sp. as the main causal agent of the deterioration of these fruits. The anti-fungal ability of the cinnamon essential oil (Cinnamomum zeynalicum) was evaluated ‘in vitro’ on the development of the isolated fungus, and ‘in vivo’ on fresh fruit at different storage temperatures, times and concentrations of AE. The results obtained showed that the most effective treatments ‘in vivo’ were 250 and 500 ppm of cinnamon essential oil. On-site analyses showed fruit stability in terms of color, texture, flavor, smell, pH and acidity, especially when there is a concentration of 500 ppm of cinnamon essential oil combined with the storage of the fruit at refrigeration temperature (5ºC), this being the most effective treatment to reduce fungal rot and loss of fruit quality. Keywords: cinnamon essential oil, postharvest, strawberry, antifungal activity, preservative. Resumen Está investigación plantea el uso de la canela como un agente antimicrobiano con la presencia de aldehído cinámico el mismo que posee actividad antibacterial, antifúngica e inhibe la producción de micotoxinas. De manera inicial se asilaron microorganismos en fresa postcosecha deteriorada, aislando colonias de Botritys sp. como el principal agente causal del deterioro de estas frutas. La capacidad antifúngica del aceite esencial de canela (Cinnamomum zeynalicum) fue evaluada ‘in vitro’ sobre el desarrollo del hongo aislado e ‘in vivo’ sobre fruta fresca a diferentes temperaturas de almacenamiento, tiempos y concentraciones de AE. Los resultados obtenidos demostraron que los tratamientos más efectivos ‘in vivo’ fueron 250 y 500 ppm de aceite esencial de canela. Los análisis in situ mostraron estabilidad de los frutos en cuanto a color, textura, sabor, olor, pH y acidez sobre todo cuando se tiene una concentración de 500 ppm de aceite esencial de canela combinado con el almacenamiento de la fruta a temperatura de refrigeración (5ºC) siendo el tratamiento más efectivo para reducir la pudrición fúngica y la pérdida de la calidad de los frutos. Palabras clave: aceite esencial de canela, post cosecha, fresa, actividad antifúngica, conservante.


2021 ◽  
Vol 8 (5) ◽  
pp. 80
Author(s):  
Michelina Pusceddu ◽  
Ignazio Floris ◽  
Nicoletta P. Mangia ◽  
Alberto Angioni ◽  
Alberto Satta

The use of natural substances such as essentials oils against bee pathogens is of great interest as an alternative to traditional methods based on synthetic compounds like antibiotics and fungicides, in order to minimize the risk of having toxic residues in hive products and to prevent the development of resistance phenomena. This study evaluated the inhibitory, fungicidal and sporicidal activity of ten essential oils extracted from aromatic plants against Ascosphaera apis, the etiological agent of chalkbrood, an invasive honey bee mycosis. The most effective essential oils were Thymus herba-barona, Thymus capitatus and Cinnamomum zeylanicum, which showed values of minimum fungicidal concentration and minimum sporicidal concentration ranging from 200 to 400 ppm. Carvacrol was the main component of Thymus capitatus and Thymus herba-barona oils, whereas cinnamic aldehyde prevailed in Cinnamomum zeylanicum oil. Further in-apiary studies will allow the evaluation of side effects on bees and residues in hive products.


Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 709
Author(s):  
Ana E. Cartaya ◽  
Halle Lutz ◽  
Sophie Maiocchi ◽  
Morgan Nalesnik ◽  
Edward M. Bahnson

Selective delivery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators to the injured vasculature at the time of vascular surgical intervention has the potential to attenuate oxidative stress and decrease vascular smooth muscle cell (VSMC) hyperproliferation and migration towards the inner vessel wall. To this end, we developed a nanoformulation of cinnamic aldehyde (CA), termed Antioxidant Response Activating nanoParticles (ARAPas), that can be readily loaded into macrophages ex vivo. The CA-ARAPas-macrophage system was used to study the effects of CA on VSMC in culture. CA was encapsulated into a pluronic micelle that was readily loaded into both murine and human macrophages. CA-ARAPas inhibits VSMC proliferation and migration, and activates Nrf2. Macrophage-mediated transfer of CA-ARAPas to VSMC is evident after 12 h, and Nrf2 activation is apparent after 24 h. This is the first report, to the best of our knowledge, of CA encapsulation in pluronic micelles for macrophage-mediated delivery studies. The results of this study highlight the feasibility of CA encapsulation and subsequent macrophage uptake for delivery of cargo into other pertinent cells, such as VSMC.


2020 ◽  
Vol 159 ◽  
pp. S88
Author(s):  
Ana Cartaya ◽  
Elena Batrakova ◽  
Edward Moreira Bahnson

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