phasic inhibition
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eLife ◽  
2022 ◽  
Vol 11 ◽  
Author(s):  
Mohit Dubey ◽  
Maria Pascual-Garcia ◽  
Koke Helmes ◽  
Dennis D Wever ◽  
Mustafa S Hamada ◽  
...  

Parvalbumin-positive (PV+) γ-aminobutyric acid (GABA) interneurons are critically involved in producing rapid network oscillations and cortical microcircuit computations but the significance of PV+ axon myelination to the temporal features of inhibition remains elusive. Here using toxic and genetic mouse models of demyelination and dysmyelination, respectively, we find that loss of compact myelin reduces PV+ interneuron presynaptic terminals, increases failures and the weak phasic inhibition of pyramidal neurons abolishes optogenetically driven gamma oscillations in vivo. Strikingly, during behaviors of quiet wakefulness selectively theta rhythms are amplified and accompanied by highly synchronized interictal epileptic discharges. In support of a causal role of impaired PV-mediated inhibition, optogenetic activation of myelin-deficient PV+ interneurons attenuated the power of slow theta rhythms and limited interictal spike occurrence. Thus, myelination of PV axons is required to consolidate fast inhibition of pyramidal neurons and enable behavioral state-dependent modulation of local circuit synchronization.


2021 ◽  
Vol 135 (3) ◽  
pp. 415-425
Author(s):  
Constance Y. Peng ◽  
Philip Jean-Richard-dit-Bressel ◽  
Sophia Gilchrist ◽  
John M. Power ◽  
Gavan P. McNally

2020 ◽  
Author(s):  
Constance Yunzhi Peng ◽  
Philip Jean-Richard-dit-Bressel ◽  
Sophia Gilchrist ◽  
John M. Power ◽  
Gavan P. McNally

AbstractIt is well established that the activity of VTA dopamine neurons is sufficient to serve as a Pavlovian reinforcer but whether this activity can also serve as instrumental reinforcer is less well understood. Here we studied the effects of optogenetic inhibition of VTA dopamine neurons in instrumental conditioning preparations. We show that optogenetic inhibition of VTA dopamine neurons causes a response-specific, contingency-sensitive suppression of instrumental responding. This suppression was due to instrumental response, not Pavlovian stimulus, learning and could not be attributed to deepened instrumental extinction learning. These effects of optogenetic inhibition of VTA dopamine neurons on instrumental responding are formally similar to the effects of aversive events in instrumental preparations and show that optogenetic inhibition of VTA dopamine neurons is sufficient to serve as an instrumental punisher.


2014 ◽  
Vol 34 (49) ◽  
pp. 16256-16272 ◽  
Author(s):  
Kirsten Hoestgaard-Jensen ◽  
Nils Ole Dalby ◽  
Jacob Krall ◽  
Harriet Hammer ◽  
Povl Krogsgaard-Larsen ◽  
...  

2014 ◽  
Vol 25 (1-2) ◽  
pp. 3-19 ◽  
Author(s):  
Bruce P Graham ◽  
Emiliano Spera

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