pathogenic effect
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2021 ◽  
Vol 50 (4) ◽  
pp. 17-20
Author(s):  
S. V. Rishchuk ◽  
S. A. Selkov ◽  
D. F. Kostyuchek ◽  
G. N. Vedeneeva ◽  
D. I. Ivin

Developing of chronic salpingoophoritis, non-specific bacterial vaginitis and specific candidamytotic vaginitis ought to be associated with complicated obstetric anamnesis and presence of biovar Parvo ureaplasmas predominantly found in womens genital tracts. The correlation may be seen between identifying biovar Parvo ureaplasmas in men and arising of torpid and chronic infectious urethritis, that may testify to its more intensive pathogenic effect comparing with biovar T- 9GO. Detection of biovar T-960 in urogenital system in men and women doesnt exclude the possibility of inflammation, that implies adequate complex therapy identical to that in case of biovar Parvo.


2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Xijing Liao ◽  
Xueyan Yang

CRISPR-Ca9 system is a newly developed gene-editing technology, which is widely used in biology and medical research. In this project, we want to knock-in a mutation found in a human pedigree into mice through CRISPR-Cas9 technology to validate its pathogenic effect. We download corresponding mice genomic sequences and design guide RNA and donor oligo sequences according to CRISPR-Cas9 target principles. Following experiments confirm that this set of sequences is effective in mice cell line.


Author(s):  
A.M. Idrisov ◽  
◽  
T.R. Gaynutdinov ◽  
R.R. Timerbaeva ◽  
G.Sh. Zakirova ◽  
...  

As a result of the work carried out, proceeding from the conceptual position of radiation parasitology about a certain commonality of the mechanisms of the pathogenic effect of ionizing radiation and parasitic agents on living organisms, we determined the conditions for modeling para-sitic invasion, as well as combined radiation-helminthic damage to the body using optimal doses of agents of invasive etiology. Irradiation of rabbits at a half-lethal dose of 7.0 Gy, produced before infection with passaluros at a dose of LD50 (1500 eggs of P. ambiguus), aggravates the course of the invasive process and promotes its generalization, accelerating the death of animals. The combined radiation-helminthic lesion proceeds quickly with the absolute death of all affected animals.


2021 ◽  
Vol 59 (05) ◽  
pp. 423-437
Author(s):  
Susann Buchheim-Schmidt ◽  
Uwe Peters ◽  
Cindy Duysburgh ◽  
Pieter Van den Abbeele ◽  
Massimo Marzorati ◽  
...  

Abstract Background Okoubaka aubrevillei is used in traditional West African medicine and in homeopathy for treatment and prevention of several gastrointestinal problems. The aim of this in vitro study was to evaluate the effect of repeated doses of two Okoubaka products (10 % ethanolic tincture, mother tincture (MT); 3rd decimal potency, 3X) on the microbial activity of physiological human colon microbiota using a Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) and to investigate any preventive effect against infections with diarrhea-causing pathogens. Methods Upon inoculation with fecal microbiota from a healthy donor, 4 parallel proximal colon compartments of the SHIME were treated either with Okoubaka MT, Okoubaka 3X, ethanol control or blank control for 7 days. Using the Okoubaka-adapted microbial community from SHIME, 48 h challenge tests were performed with enterotoxigenic Escherichia coli (ETEC) and Salmonella enteritidis in 4 different doses (103–108 colony forming units as typical in vivo infectious doses). Pathogen concentrations, short-chain fatty acids (SCFAs) and branched SCFA production were measured in triplicate at 0, 24 and 48 h. Results In the challenge tests, both Okoubaka products were able to restrict the colonization of ETEC and Salmonella at 3 of the 4 pathogen doses (except the highest doses), with a stronger anti-pathogenic effect for MT, which included a reduction of 2.0 log-units of ETEC (p < 0.0001) and 1.1 log-units of Salmonella (p < 0.0001). Total SCFA levels remained unaffected, but butyrate increased during the first 24 h (p < 0.0001 for ETEC), accompanied by decreased acetate production. Conclusion We observed in vitro a systemic activating effect of Okoubaka on intestinal microbiome resistance, which resulted in an anti-pathogenic effect, especially against ETEC. We hypothesize that the mode of action in vivo is also based on systemic regulative effects.


Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 336
Author(s):  
Ignacio J. Cardona-Benavides ◽  
Cristina de Ramón ◽  
Norma C. Gutiérrez

Some genetic abnormalities of multiple myeloma (MM) detected more than two decades ago remain major prognostic factors. In recent years, the introduction of cutting-edge genomic methodologies has enabled the extensive deciphering of genomic events in MM. Although none of the alterations newly discovered have significantly improved the stratification of the outcome of patients with MM, some of them, point mutations in particular, are promising targets for the development of personalized medicine. This review summarizes the main genetic abnormalities described in MM together with their prognostic impact, and the therapeutic approaches potentially aimed at abrogating the undesirable pathogenic effect of each alteration.


2021 ◽  
Vol 36 ◽  
pp. 06034
Author(s):  
K. Sidorenko ◽  
M. Mkrtchyan ◽  
O. Kaidalova

Rabbit breeding is one of the promising branches of animal husbandry, but its development is hampered by various diseases. The problem of the pathogenic influence of parasites of the genus Eimeria on the organism of rabbits at different infective doses is still quite urgent. The study was conducted on hybrids of rabbits of Soviet Chinchilla and Californian breeds at 30 and 45 days of age. Within the framework of the experiment 6 groups of young rabbits were formed by the method of pair-analogs. The one-day old rabbits in the experimental groups were infected with oocysts of the association of Eimeria species E. perforans and E. irresidua at doses of 100 000 (2 groups) and 200 000(2 groups) per head, and in control groups (2 groups) - remained intact throughout the experiment. To analyze the pathogenic effect of parasites determination of meat productivity, veterinary and sanitary assessment of carcasses, linear measurements of intestinal length as well as histological studies of the walls of the small intestine were carried out in rabbits of these age groups. The research results showed that rabbits-hybrids infected at a dose of 100 000 and 200 000 oocysts per head demonstrate significant reduction of the increase in live weight and slaughter yield, despite the preservation of the retail display of the carcasses.


2021 ◽  
Vol 285 ◽  
pp. 02043
Author(s):  
Natalia Tumanyan ◽  
Tatyana Kumeiko ◽  
Sergey Garkusha

The analysis of grain damage in the form of dark spots of Russian rice varieties grown in Krasnodar region in 2011-2020 has been carried out. Rice grain was damaged during the filling period, mainly in full ripeness. The high degree of damage was the reason for the deterioration of grain quality. The degree of damage varied over the years. 2011 and 2012 were characterized by a high content of damaged grains (up to 3-20%). The degree of damage to rice grain was different in different agar-landscape zones of Krasnodar region: in the Krasnoarmeysky district it was higher than in the Abinsky. On panicles of variety Rapan without stinkbugs, one caryopsis with damage was found, while on panicles with stinkbugs, their number increased to 12.4-20.3%. In variety Kurazh, damage to caryopses in the form of dark spots on panicles with stinkbugs reached 10.1-19.1%. A significant increase in the degree of damage to rice grain stored in storage began in 2011. In 2011, the content of damaged grains increased by more than 1%, in 2012 it reached 8.3% in the Slavyansky district. Since 2013, the degree of damage to rice grain in the field began to decrease. It is concluded that the damage is associated with the pathogenic effect on the plant and the caryopsis of bug insects with a piercing-sucking mouth apparatus. Damage to caryopses was insignificant in 2015-2020.


2021 ◽  
Vol 29 (2) ◽  
pp. 159-161
Author(s):  
Manisha ◽  
S.P. Bishnoi ◽  
B.S. Chandrawat ◽  
H.R. Gurjar ◽  
Rinku Yadav ◽  
...  

2020 ◽  
Vol 02 (11) ◽  
pp. 167-171
Author(s):  
Abdujabbor Sattorovich Bekmurodov ◽  
◽  
Masuma Umarovna Raxmatova ◽  

The article provides data on the ecological grouping of detected phytonematodes on pomegranate agrocenoses of the Surkhandarya region of Uzbekistan. The study revealed 98 species of phytonematodes belonging to 5 ecological groups: pararisobionts-20 species, devisaprobionts-23, eusaprobionts-4, phytohelminths of nonspecific pathogenic effect-34 and phytohelminths of specific pathogenic effect-17.


2020 ◽  
Author(s):  
Peter T. Habib

AbstractThe term chimeric virus was not popular in the last decades. Recently, according to current sequencing efforts in discovering COVID-19 Secrets, the generated information assumed the presence of 6 Coronavirus main strains, but coronavirus diverges into hundreds of sub-strains. the bottleneck is the mutation rate. With two mutation/month, humanity will meet a new sub-strain every month. Tracking new sequenced viruses is urgently needed because of the pathogenic effect of the new substrains. here we introduce COVATOR, A user-friendly and python-based software that identifies viral chimerism. COVATOR aligns input genome and protein that has no known source, against genomes and protein with known source, then gives the user a graphical summary.


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