pegylated protein
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Fast and high-resolution purification of a PEGylated protein using a z2 laterally-fed membrane chromatography device

2021 ◽  
pp. 462375
Author(s):  
Guoqiang Chen ◽  
John Pagano ◽  
Deqiang Yu ◽  
Sanchayita Ghose ◽  
Zhengjian Li ◽  
...  
Keyword(s):  
High Resolution ◽  
Membrane Chromatography ◽  
Pegylated Protein

High-resolution purification of a therapeutic PEGylated protein using a cuboid packed-bed device

2020 ◽  
Vol 1630 ◽  
pp. 461524
Author(s):  
Guoqiang Chen ◽  
Umatheny Umatheva ◽  
John Pagano ◽  
Deqiang Yu ◽  
Sanchayita Ghose ◽  
...  
Keyword(s):  
High Resolution ◽  
Packed Bed ◽  
Pegylated Protein

Adverse vacuolation in multiple tissues in cynomolgus monkeys following repeat-dose administration of a PEGylated protein

2019 ◽  
Vol 317 ◽  
pp. 120-129 ◽  
Author(s):  
Anthony M. Fletcher ◽  
Pierre Tellier ◽  
Julie Douville ◽  
Peter Mansell ◽  
Michael J. Graziano ◽  
...  
Keyword(s):  
Repeat Dose ◽  
Dose Administration ◽  
Cynomolgus Monkeys ◽  
Pegylated Protein

Mechanisms of activity loss for a multi-PEGylated protein by experiment and simulation

2019 ◽  
Vol 12 ◽  
pp. 121-131 ◽  
Author(s):  
A. Zaghmi ◽  
E. Mendez-Villuendas ◽  
A.A. Greschner ◽  
J.Y. Liu ◽  
H.W. de Haan ◽  
...  
Keyword(s):  
Experiment And Simulation ◽  
Activity Loss ◽  
Pegylated Protein

Controlled synthesis of PEGylated surface protein-imprinted nanoparticles

The Analyst ◽  
2019 ◽  
Vol 144 (18) ◽  
pp. 5439-5448 ◽  
Author(s):  
Xue Yang ◽  
Yan Sun ◽  
Yang Xiang ◽  
Fengtao Qiu ◽  
Guoqi Fu
Keyword(s):  
Raft Polymerization ◽  
Surface Protein ◽  
Controlled Synthesis ◽  
Pegylated Protein

Controlled synthesis of PEGylated protein-imprinted nanoparticles with enhanced recognition selectivity via surface-initiated RAFT polymerization.

scholarly journals Molecular insights into the improved clinical performance of PEGylated interferon therapeutics: a molecular dynamics perspective

RSC Advances ◽  
2018 ◽  
Vol 8 (5) ◽  
pp. 2315-2322 ◽  
Author(s):  
Dong Xu ◽  
Nikolai Smolin ◽  
Rance K. Shaw ◽  
Samuel R. Battey ◽  
Aoxiang Tao ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Drug Design ◽  
Therapeutic Efficacy ◽  
Clinical Performance ◽  
Pegylated Interferon ◽  
Computational Approach ◽  
Molecular Evidence ◽  
Protein Drug ◽  
Pegylated Protein

We discovered molecular evidence that links PEGylation to improved clinical performance, yet at the expense of decreased bioactivity. Our computational approach will facilitate PEGylated protein drug design and optimize its overall therapeutic efficacy.

Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance

2017 ◽  
Vol 14 (5) ◽  
pp. 1429-1438 ◽  
Author(s):  
Yingzhi Chen ◽  
Meng Zhang ◽  
Hongyue Jin ◽  
Yisi Tang ◽  
Aihua Wu ◽  
...  
Keyword(s):  
Protein Toxin ◽  
Pegylated Protein

Selective functional activity measurement of a PEGylated protein with a modification-dependent activity assay

2017 ◽  
Vol 132 ◽  
pp. 207-214 ◽  
Author(s):  
Alfred Weber ◽  
Andrea Engelmaier ◽  
Gabriele Mohr ◽  
Sonja Haindl ◽  
Hans Peter Schwarz ◽  
...  
Keyword(s):  
Functional Activity ◽  
Activity Measurement ◽  
Activity Assay ◽  
Dependent Activity ◽  
Pegylated Protein
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