“Moving the Science Forward”: Faculty Perceptions of Culturally Diverse Mentor Training Benefits, Challenges, and Support

This study applied social exchange theory to examine 74 faculty members’ perceptions of culturally diverse mentor training activities at 10 undergraduate institutions in the early stages of implementing grant-funded interventions focused on determining the most effective ways to engage and retain racially diverse students in biomedical research.

The Association Between Loneliness and Inflammation: Findings From an Older Adult Sample

Loneliness has been linked to poor mental and physical health outcomes. Past research suggests that inflammation is a potential pathway linking loneliness and health, but little is known about how loneliness assessed in daily life links with inflammation, or about linkages between loneliness and inflammation among older adults specifically. As part of a larger investigation, we examined the cross-sectional associations between loneliness and a panel of both basal and LPS-stimulated inflammatory markers. Participants were 222 socioeconomically and racially diverse older adults (aged 70–90 years; 38% Black; 13% Hispanic) systematically recruited from the Bronx, NY. Loneliness was measured in two ways, with a retrospective trait measure (the UCLA Three Item Loneliness Scale) and an aggregated momentary measure assessed via ecological momentary assessment (EMA) across 14 days. Inflammatory markers included both basal levels of C-reactive protein (CRP) and cytokines (IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α) and LPS-stimulated levels of the same cytokines. Multiple regression analyses controlled for age, body-mass index, race, and depressive symptoms. Moderation by gender and race were also explored. Both higher trait loneliness and aggregated momentary measures of loneliness were associated with higher levels of CRP (β = 0.16, p = 0.02; β = 0.15, p = 0.03, respectively). There were no significant associations between loneliness and basal or stimulated cytokines and neither gender nor race were significant moderators. Results extend prior research linking loneliness with systemic inflammation in several ways, including by examining this connection among a sample of older adults and using a measure of aggregated momentary loneliness.

“No Way! Like Only Hispanics are Illegal”: Examining the Racialized Psychosocial Development of Migrant “Illegality” Across Immigrant Groups in the United States

Building on recent studies of “racialized illegality,” this paper examines the psychosocial development of migrant “illegality” in a sample of ethnically and racially diverse immigrant young people. In-depth interviews and fieldnotes were collected in Chicago with White, Asian and Pacific Islander, and Latina/o immigrants ( N = 43; 14–33 years of age; 15 male, 28 female) who were undocumented and/or grew up in families with at least one undocumented parent, and who were asked to reflect on these experiences. Drawing upon the cycles of deportability framework, we theorize the psychosocial development of migrant “illegality” as a dynamic process driven by repeated, cyclical experiences with status-related stressors that regularly prompt acute fears as well as carry long-term psychosocial effects. Examining these cycles within our respondents’ reflections, we find discernible differences in both the types of status-related stressors and contexts of support experienced by Latina/o and non-Latina/o respondents, pointing to different cycles of deportability that vary along racial-ethnic lines. We maintain that these findings reflect the racialized context of migrant “illegality” in the United States, which targets primarily Latina/o migrants, as well as points to the need for increased supports for undocumented immigrants in non-Latina/o immigrant communities.

RNA profiles reveal signatures of future health and disease in pregnancy

Maternal morbidity and mortality continue to rise, and pre-eclampsia is a major driver of this burden1. Yet the ability to assess underlying pathophysiology before clinical presentation to enable identification of pregnancies at risk remains elusive. Here we demonstrate the ability of plasma cell-free RNA (cfRNA) to reveal patterns of normal pregnancy progression and determine the risk of developing pre-eclampsia months before clinical presentation. Our results centre on comprehensive transcriptome data from eight independent prospectively collected cohorts comprising 1,840 racially diverse pregnancies and retrospective analysis of 2,539 banked plasma samples. The pre-eclampsia data include 524 samples (72 cases and 452 non-cases) from two diverse independent cohorts collected 14.5 weeks (s.d., 4.5 weeks) before delivery. We show that cfRNA signatures from a single blood draw can track pregnancy progression at the placental, maternal and fetal levels and can robustly predict pre-eclampsia, with a sensitivity of 75% and a positive predictive value of 32.3% (s.d., 3%), which is superior to the state-of-the-art method2. cfRNA signatures of normal pregnancy progression and pre-eclampsia are independent of clinical factors, such as maternal age, body mass index and race, which cumulatively account for less than 1% of model variance. Further, the cfRNA signature for pre-eclampsia contains gene features linked to biological processes implicated in the underlying pathophysiology of pre-eclampsia.

Dementia and autopsy-verified causes of death in racially-diverse older Brazilians

Background While dementia has been associated with specific causes of death, previous studies were relatively small autopsy series or population-based studies lacking autopsy confirmation and were restricted to Non-Latinx Whites. Here, we examine the association of dementia with autopsy-verified causes of death in racially-diverse older Brazilians. Methods As part of the Pathology, Alzheimer´s and Related Dementias Study (PARDoS), a community-based study in Brazil, we included 1941 racially-diverse deceased, 65 years or older at death. We conducted a structured interview with legal informants including the Clinical Dementia Rating (CDR) Scale for dementia proximate to death. Causes of death were assessed after full-body autopsy and macroscopic examination of the brain, thoracic and abdominal/pelvic organs. Up to four causes of death were reported for each decedent. Causes of death were classified as circulatory, infectious, cancer and other. Logistic regression was used to determine associations of dementia with cause of death, controlling for age, sex, race, and education. Results Dementia was associated with a higher odds of an infectious cause of death (OR = 1.81, 95%CI:1.45–2.25), and with a lower odds of a circulatory disease as cause of death (OR = 0.69, 95%CI:0.54–0.86) and cancer as cause of death (OR = 0.41, 95%CI:0.24–0.71). Dementia was associated with a higher odds of pneumonia (OR = 1.92, 95%CI:1.53–2.40) and pulmonary embolism (OR = 2.31, 95%CI:1.75–3.05) as causes of death and with a lower odds of acute myocardial infarction (OR = 0.42, 95%CI:0.31–0.56) and arterial disease (OR = 0.76, 95%CI:0.61–0.94) as causes of death. Conclusion Racially-diverse older Brazilians with dementia had a higher odds of an infectious cause of death and a lower odds of cancer and circulatory disease as causes of death than those without dementia.

Valuations of diversity: The role of marquee quotas in creative industries (Working Paper)

We examine how creative industry workers engage with diversity, absent a formal organizational mandate to do so. Through in-depth interviews with independent music industry personnel (N=50), we find that marquee quotas -- racially diverse representation on rosters and festival bills -- guide how diversity is sought and implemented. Such quotas are justified via four distinct valuations of diversity: aesthetic, economic, reputational, and moral. Both racialized and white participants justify the importance of diversity on moralistic grounds. By contrast, white participants more often justify the value of diversity by making claims about the aesthetic, economic and reputational benefits of marquee quotas. The deployment of these more self-serving valuations has consequences for the extent to which people of colour can be authentically included. Our analysis contributes to critiques of the socio-economic role and consequences of diversity initiatives, within the context of a creative industry.