cancer drugs
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2022 ◽  
Vol 11 ◽  
Author(s):  
Hai-ni Wen ◽  
Chen-yu Wang ◽  
Jin-meng Li ◽  
Zheng Jiao

The cardiotoxicity of anti-cancer drugs presents as a challenge to both clinicians and patients. Significant advances in cancer treatments have improved patient survival rates, but have also led to the chronic effects of anti-cancer therapies becoming more prominent. Additionally, it is difficult to clinically predict the occurrence of cardiovascular toxicities given that they can be transient or irreversible, with large between-subject variabilities. Further, cardiotoxicities present a range of different symptoms and pathophysiological mechanisms. These notwithstanding, mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling offers an important approach to predict cardiotoxicities and offering precise cardio-oncological care. Efforts have been made to integrate the structures of physiological and pharmacological networks into PK-PD modeling to the end of predicting cardiotoxicities based on clinical evaluation as well as individual variabilities, such as protein expression, and physiological changes under different disease states. Thus, this review aims to report recent progress in the use of PK-PD modeling to predict cardiovascular toxicities, as well as its application in anti-cancer therapies.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Aparna Das ◽  
Bimal Krishna Banik

Abstract The insertion of a molecule between the bases of DNA is known as intercalation. A molecule is able to interact with DNA in different ways. DNA intercalators are generally aromatic, planar, and polycyclic. In chemotherapeutic treatment, to suppress DNA replication in cancer cells, intercalators are used. In this article, we discuss the anticancer activity of 10 intensively studied DNA intercalators as drugs. The list includes proflavine, ethidium bromide, doxorubicin, dactinomycin, bleomycin, epirubicin, mitoxantrone, ellipticine, elinafide, and echinomycin. Considerable structural diversities are seen in these molecules. Besides, some examples of the metallo-intercalators are presented at the end of the chapter. These molecules have other crucial properties that are also useful in the treatment of cancers. The successes and limitations of these molecules are also presented.


2022 ◽  
Vol 9 ◽  
Author(s):  
Laura Bongiovanni ◽  
Philip J. Bergman ◽  
Alain de Bruin

Like their owners, dogs and cats can be affected by several types of cancer, and some types are very similar to those seen in people. Unfortunately, there is still no cure for several types of cancer. How can humans’ best friends help? If a new therapy to fight cancer works well in pets, it is likely to also be effective in people with the same type of cancer. Scientists, medical doctors, and animal doctors are working together to develop new therapies that destroy cancer cells and save patients. Since the characteristics of certain types of cancer are very similar between humans and pets, new medicines that work in pet dogs or cats may also benefit human patients. Studying these “human-like” cancers in pets may speed up the development of effective anti-cancer drugs and will help to cure not only more dogs and cats, but also people with cancer.


2022 ◽  
Vol 23 (1) ◽  
pp. e1
Author(s):  
Mitchell J Elliott ◽  
Eitan Amir ◽  
Sallie-Anne Pearson ◽  
Michael B Barton ◽  
Brooke E Wilson
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2022 ◽  
Vol 23 (1) ◽  
pp. e2
Author(s):  
Corinna Victoria M Puyat ◽  
Michelle Ann B Eala ◽  
Edward Christopher Dee ◽  
Ourlad Alzeus G Tantengco ◽  
Anna Rominia D P Cruz ◽  
...  
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