Non-intimate Relationships and Psychopathic Interpersonal and Affective Deficits as Risk Factors for Criminal Career: A Comparison Between Sex Offenders and Other Offenders

Sex-offenders are at risk of criminal recidivism. For the treatment to be truly effective, it must be individualized. For this purpose, an accurate assessment should focus on criminological, psychological, and psychopathological features. The present study compared sex offenders with other offenders on historical experiences (i.e., problems with violence, anti-social behaviors, problems with personal relationships, problems with substance use, traumatic experiences, and parenting style). In addition, given the association between life events and psychopathy, we explored whether the relation between life events and crime type (sexual crime vs. other types of crime) might be moderated by psychopathy traits (interpersonal and affective deficits and antisocial behavior). Eighty-eight sex offenders (76% of whom child molesters) and 102 other offenders were included. The Historical, Clinical and Risk Management - 20 item Version 3 (HCR-20V3) and Psychopathy Checklist-Revised (PCL-R) were administered. The scores of the HCR-20V3 Historical scale items were computed to assess life events. The scores of the PCL-R factors, F1 Interpersonal affective deficits and F2 Antisocial behavior, were recorded. The presence of a history of problems with non-intimate relationships was the only significant risk factor for sexual crime compared with other crimes. Interpersonal and affective deficits provided an increased likelihood of being sex offenders as compared with other offenders when problems with non-intimate relationships were possibly/partially or certainly present.

Associations Between Psychopathic Traits and Laboratory-Based Aggression: Moderating Effects of Provocation and Distraction

There are two distinct combinations of psychopathic traits (primary and secondary) that have been proposed to be a function of unique cognitive-affective deficits. This study sought to use theories of psychopathy to understand the factors that exacerbate (i.e., provocation) and attenuate (i.e., distraction) aggression in individuals high in psychopathic traits in a controlled laboratory task. Male undergraduates, who scored across the range of primary and secondary psychopathic traits, completed the Taylor Aggression Paradigm (TAP; Taylor, 1967 ) under conditions of low and high provocation. Participants were also randomly assigned to either a distraction condition, in which they completed a distracting concurrent task, or a control condition, in which no such task was completed. Inconsistent with our prediction, results showed that regardless of condition, primary psychopathic traits were positively related to laboratory aggression. Consistent with our hypothesis, a positive association between secondary psychopathic traits and laboratory physical aggression was observed following high provocation among nondistracted participants; this association was significantly reduced among distracted participants. These results clarify the factors that contribute to aggression for individuals high in psychopathic traits and may provide directions for future intervention development.

Predicting motor gains with home-based telerehabilitation after stroke

Introduction Telerehabilitation (TR) may be useful for rehabilitation therapy after stroke. However, stroke is a heterogeneous condition, and not all patients can be expected to derive the same benefit from TR, underscoring the need to identify predictors of response to TR. Methods A prior trial provided patients with 6 weeks of intensive rehabilitation therapy targeting arm movement, randomly assigned to be provided in the home via TR (current focus) or in clinic. Eligible patients had moderate arm motor deficits and were in the subacute–chronic stage post stroke. Behavioral gains were measured as change in the arm motor Fugl-Meyer score from baseline to 30 days post therapy. To delineate predictors of TR response, multivariable linear regression was performed, advancing the most significant predictor from each of eight categories: patient demographics, stroke characteristics, medical history, rehabilitation therapy outside of study procedures, motivation, sensorimotor impairment, cognitive/affective deficits, and functional status. Results The primary focus was on patients starting TR >90 days post stroke onset ( n = 44), among whom female sex, less spasticity, and less visual field defects predicted greater motor gains. This model explained 39.3% of the variance in treatment-related gains. In secondary analysis that also included TR patients enrolled ≤90 days post stroke (total n = 59), only female sex was a predictor of treatment gains. A separate secondary analysis examined patients >90 days post stroke ( n = 34) randomized to in-clinic therapy, among whom starting therapy earlier post stroke and less ataxia predicted greater motor gains. Discussion Response to TR varies across patients, emphasizing the need to identify characteristics that predict treatment-related behavioral gain. The current study highlights factors that might be important to patient selection for home-based TR after stroke.

From stress to depression: development of extracellular matrix-dependent cognitive impairment following social stress

Stress can predispose to depressive episodes, yet the molecular mechanisms regulating the transition from the initial stress response to a persistent pathological depressive state remain poorly understood. We profiled the development of an enduring depressive-like state by assessing affective behavior and hippocampal function during the 2 months following social-defeat stress. We measured remodeling of hippocampal extracellular matrix (ECM) during this period, as we recently identified ECM changes to mediate cognitive impairment during the sustained depressive-like state. Affective disturbance and cognitive impairments develop disparately after social stress, with gradual appearance of affective deficits. In contrast, spatial memory was impaired both early after stress and during the late-emerging chronic depressive-like state, while intact in-between. Similarly, we observed a biphasic regulation of the hippocampal ECM coinciding with hippocampus-dependent memory deficits. Together our data (1) reveal a dichotomy between affective and cognitive impairments similar to that observed in patients, (2) indicate different molecular processes taking place during early stress and the chronic depressive-like state, and (3) support a role of the ECM in mediating long-lasting effects on memory. From a translational point of view, it is important to prioritize on temporal phenotypic aspects in animal models to elucidate the underlying mechanisms of depression.

“From an old life to a new life”: Group therapy for cognitive disorders and affective deficits in adolescents who have committed sexual offenses

The purpose of the current article is to shed light on the unique population of adolescents who have committed sexual offenses, suffering from cognitive disorders, by presenting the disorders and challenges that characterize these youngsters and discussing the issues that are relevant to the therapeutic process of sexual offenses. In our article we show the correlations and adaptations that we made to provide these boys with the most effective treatment possible, both to enable them to undergo an optimal process and to lower their risk level for recidivism.

The association between toddlerhood empathy deficits and antisocial personality disorder symptoms and psychopathy in adulthood

The present study examined empathy deficits in toddlerhood (age 14 to 36 months) as predictors of antisocial personality disorder (ASPD) symptoms and psychopathy measured by the Levenson Self-Report Psychopathy scale (Levenson, Kiehl, & Fitzpatrick, 1995) in adulthood (age 23 years) in 956 individuals from the Colorado Longitudinal Twin Study. Consistent with the hypothesis that antisocial behavior is associated with “active” rather than “passive” empathy deficits, early disregard for others, not lack of concern for others, predicted later ASPD symptoms. Early disregard for others was also significantly associated with factor 1 of the Levenson Self-Report Psychopathy Scale, which includes items assessing interpersonal and affective deficits, but not with factor 2, which includes items assessing impulsivity and poor behavioral control. The association between early disregard for others and psychopathy factor 2 was near zero after controlling for the shared variance between psychopathy factors 1 and 2. These results suggest that there is a propensity toward adulthood ASPD symptoms and psychopathy factor 1 that can be assessed early in development, which may help identify individuals most at risk for stable antisocial outcomes.

Subjective Uncontrollability over Aversive Events Reduces Working Memory Performance and Related Large-Scale Network Interactions

Lack of control over significant events may induce a state of learned helplessness that is characterized by cognitive, motivational, and affective deficits. Although highly relevant in the pathogenesis of several mental disorders, the extent of the cognitive deficits induced by experiences of uncontrollability and the neural mechanisms underlying such deficits in humans remain poorly understood. Using functional magnetic resonance imaging (fMRI), we tested here whether uncontrollability over aversive events impairs subsequent working memory performance and, if so, which neural processes are involved in such deficits. We assessed working memory and the involved neurocircuitry in the MRI scanner before and after participants underwent a task in which they could either learn to avoid electric shocks or had no instrumental control over shocks. Our results show that subjective, but not objective, uncontrollability over aversive events impaired working memory performance. This impact of subjective uncontrollability was linked to altered prefrontal and parahippocampal activities and connectivity as well as decreased crosstalk between frontoparietal executive and salience networks. Our findings show that the perceived uncontrollability over aversive events, rather than the aversive events themselves or the actual, objective control over them, disrupts subsequent working memory processes, most likely through altered crosstalk between prefrontal, temporal, and parietal areas.

From stress to depression: Development of extracellular matrix-dependent cognitive impairment following social stress

Stress can predispose to depressive episodes, yet the molecular mechanisms regulating the transition from the initial stress response to a persistent pathological depressive state remain poorly understood. To shed light on this stress-to-depression transition process, we profiled the development of an enduring depressive-like state in rat by assessing affective behavior and hippocampal function during the 2 months following social defeat stress. In addition, we measured remodeling of hippocampal extracellular matrix (ECM) during this period, as we recently identified ECM changes to mediate cognitive impairment during a sustained depressive-like state. We found affective disturbance and cognitive impairment to develop disparately after social stress. While affective deficits emerged gradually, spatial memory impairment was present both early after stress and during the late-emerging chronic depressive-like state. Surprisingly, these phases were separated by a period of normalized hippocampal function. Similarly, the SDPS paradigm induced a biphasic regulation of the hippocampal ECM coinciding with hippocampus-dependent memory deficits. Early after stress, synaptic ECM proteins and the number of perineuronal nets enwrapping parvalbumin-expressing interneurons were decreased. This was followed by a recovery period without ECM dysregulation, before subsequent decreased metalloproteinase activity and ECM build-up, previously shown to impair memory. This suggests that intact hippocampal function requires unaltered ECM levels. Together our data 1) reveal a dichotomy between affective and cognitive impairments similar to that observed in patients, 2) indicate different molecular processes taking place during early stress and the chronic depressive-like state, and 3) support a role of the ECM in mediating long-lasting memory-effects of social stress.

Cerebellar contribution to emotional body language perception: a TMS study

Consistent evidence suggests that the cerebellum contributes to the processing of emotional facial expressions. However, it is not yet known whether the cerebellum is recruited when emotions are expressed by body postures or movements, or whether it is recruited differently for positive and negative emotions. In this study, we asked healthy participants to discriminate between body postures (with masked face) expressing emotions of opposite valence (happiness vs anger, Experiment 1), or of the same valence (negative: anger vs sadness; positive: happiness vs surprise, Experiment 2). While performing the task, participants received online transcranial magnetic stimulation (TMS) over a region of the posterior left cerebellum and over two control sites (early visual cortex and vertex). We found that TMS over the cerebellum affected participants’ ability to discriminate emotional body postures, but only when one of the emotions was negatively valenced (i.e. anger). These findings suggest that the cerebellar region we stimulated is involved in processing the emotional content conveyed by body postures and gestures. Our findings complement prior evidence on the role of the cerebellum in emotional face processing and have important implications from a clinical perspective, where non-invasive cerebellar stimulation is a promising tool for the treatment of motor, cognitive and affective deficits.

Perception and experience of musical emotions in schizophrenia

The schizophrenic disturbance of affective processing has seen a welcome revival in academic inquiry. However, laboratory research on emotion in schizophrenia has largely drawn on facial and prosodic stimuli and the suitability of this practice has been questioned. This article aims to explore the utility of musical material, and to motivate its use in research on emotion in schizophrenia. The article lists some of the empirical advantages of musical material and describes key auditory and affective deficits which could alter musical emotions in schizophrenia. Existing findings pertaining to the perception and experience of musical arousal and valence in schizophrenia are reviewed and compared with nonmusical findings. Results suggest that schizophrenia affects the recognition of both musical and nonmusical emotions. However, musical and nonmusical emotions appear to differ in that: 1) musical emotions are more arousing, 2) negative musical emotions stimulate approach tendencies, and 3) both the perception and experience of musical emotions share these characteristics. These differences are presently unexplained and warrant further investigation. An improvement in the use of musical material in research on emotion in schizophrenia is justified.