Characteristics of two complex rock and glacier avalanches and RAMMS simulation of a long-runout disaster in the Sedongpu Basin of the Yarlung Zangbo River downstream in October 2018, Tibet, China

On October 17 and 29, 2018, two rock and glacier avalanches occurred on the western slope of the Sedongpu Basin upstream of the Yarlung Zangbo River in the Tibetan Plateau, forming the disaster chains and causing damage to many bridges and roads. Based on the comparative analysis of multiple pre-and post-remote sensing images, the initial sliding body, which was composed of rock and glacial material, was located on a steep slope above an elevation of 6000 m. Under the coupling effect of multiple factors such as gravity, rainfall, and weather changes, the initial sliding body detached from the source zone and then transformed into a debris flow after impact and fragmentation. The debris flow traveled downstream and scraped loose glacial till in its path, causing the volume of the sliding body to increase. In addition, the debris flow traveled 10 km under low frictional resistance, as a result of the lubrication via early rainfall and glacial meltwater. Eventually, the debris flow rushed out onto the valley floor, forming a landslide dam and blocking the Yarlung Zangbo River. The deposit volumes on October 17 and 29 were 20.4 million m3 and 10.1 million m3, respectively, with a total mean thickness of ~22m. This study provides an insight into the dynamic process as they unfolded, through multitemporal satellite imagery and numerical simulation. Furthermore, we also discuss the potential cause of rock/ice avalanche and disaster scenarios, as well as the tendency of the rock and glacier avalanches are discussed.

Associations Between Canada's Cannabis Legalization and Emergency Department Presentations for Transient Cannabis-Induced Psychosis and Schizophrenia Conditions: Ontario and Alberta, 2015–2019

Objective Cannabis legalization in many jurisdictions worldwide has raised concerns that such legislation might increase the burden of transient and persistent psychotic illnesses in society. Our study aimed to address this issue. Methods Drawing upon emergency department (ED) presentations aggregated across Alberta and Ontario, Canada records (April 1, 2015–December 31, 2019), we employed Seasonal Autoregressive Integrated Moving Average (SARIMA) models to assess associations between Canada's cannabis legalization (via the Cannabis Act implemented on October 17, 2018) and weekly ED presentation counts of the following ICD-10-CA-defined target series of cannabis-induced psychosis (F12.5; n = 5832) and schizophrenia and related conditions (“schizophrenia”; F20-F29; n = 211,661), as well as two comparison series of amphetamine-induced psychosis (F15.5; n = 10,829) and alcohol-induced psychosis (F10.5; n = 1,884). Results ED presentations for cannabis-induced psychosis doubled between April 2015 and December 2019. However, across all four SARIMA models, there was no evidence of significant step-function effects associated with cannabis legalization on post-legalization weekly ED counts of: (1) cannabis-induced psychosis [0.34 (95% CI −4.1; 4.8; P = 0.88)]; (2) schizophrenia [24.34 (95% CI −18.3; 67.0; P = 0.26)]; (3) alcohol-induced psychosis [0.61 (95% CI −0.6; 1.8; P = 0.31); or (4) amphetamine-induced psychosis [1.93 (95% CI −2.8; 6.7; P = 0.43)]. Conclusion Implementation of Canada's cannabis legalization framework was not associated with evidence of significant changes in cannabis-induced psychosis or schizophrenia ED presentations. Given the potentially idiosyncratic rollout of Canada's cannabis legalization, further research will be required to establish whether study results generalize to other settings.

Hiệu quả của phương pháp oxy hóa qua màng ngoài cơ thể (ECMO) trong hỗ trợ điều trị hội chứng suy hô hấp cấp nguy kịch trên bệnh nhân Covid

TÓM TẮT Sự bùng phát của hội chứng viêm đường hô hấp cấp do coronavirus 2 (SARS-CoV-2) nhanh chóng trở thành đại dịch trên toàn thế giới với hơn 40 triệu người mắc và hơn 1 triệu người chết tính đến ngày 17 tháng 10 năm 2020. Nhiều bệnh nhân COVID-19 được báo cáo cho thấy rằng có thể dẫn đến suy hô hấp cấp cần chăm sóc đặc biệt (ICU) và thiết bị hỗ trợ thở và bệnh cảnh có thể nhanh chóng tiến triển thành chứng suy hô hấp cấp (ARDS) với thiếu oxy ở mức độ nặng và gây ra tử vong dù đã có sự hỗ trợ của thiết bị hỗ trợ thở, cả 2 khả năng này thậm chí có thể cùng xảy ra. Các tổ chức quốc tế và các chuyên gia trong lĩnh vực này khuyến nghị sử dụng ECMO cho những bệnh nhân ARDS bị bệnh nặng có COVID-19. Tuy nhiên, tỷ lệ sống sót là rất thấp trong những trường hợp được sử dụng ECMO với COVID-19 trong đợt đầu tiên. Nghiên cứu của chúng tôi nhằm đánh giá kết quả bước đầu ứng dụng kỹ thuật ECMO trong hỗ trợ điều trị hội chứng suy hô hấp cấp nguy kịch trên bệnh nhân COVID-19 tại trung tâm hồi sức bệnh viện Trung ương Huế. ABSTRACT EFFECTIVENESS OF EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) IN THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME IN PATIENTS WITH COVID-19 The outbreak of acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) quickly developed into a worldwide pandemic with more than 40 million people infected and more than 1 million dead as of October 17, 2020. Numerous patient reports COVID-19 can lead to acute respiratory failure requiring intensive care (ICU) and ventilators, and it can rapidly evolve into a certificate of acute respiratory failure (ARDS) with red oxygen in the heavy and death, despite the protective ventilator, even both. International organizations and experts in the field recommend ECMO for critically ill ARDS patients with COVID-19. However, survival is very low in the ECMO - corrected case series with COVID-19 during the first COVID-19 wave. Our study aimed to evaluate the results of the initial application of transmembrane oxygenation (ECMO) technique in the support of critical acute respiratory distress syndrome on COVID-19 patients at the hospital resuscitation center of Hue central hospital. Keywords: ECMO, ARDS, COVID-19.

Aggravation of interfaith relations in the Belarusian provinces of the Russian Empire (late 19th – early 20th century) in the light of archival documents

The article analyzes various aspects of the relationship between the largest confessional groups of the Belarusian provinces of the Russian Empire (Orthodox and Catholics) in the late 19th – early 20th centuries in the context of the implementation of the models of self-identification «our – other» and «our – alien». Particular attention is paid to the characteristics of the activities of Catholic clergy and fanatical parishioners to incite interfaith hostility (insults to representatives of another confession, unfounded calls for conversion to Catholicism, erroneous interpretation of the Decree «On strengthening the principles of religious tolerance» and the Manifesto of October 17, 1905, and etc.). The authority that Catholic priests had among the parishioners often caused the latter to be hostile to their neighbors of other faiths. The article provides many examples of the fact that the appearance of fanatical priests in a certain area often disrupted the peaceful, conflict-free course of religious life. At the same time, there were cases when the erroneous actions of Orthodox priests and ordinary parishioners became a catalyst for the exacerbation of interfaith relations. The article provides factual evidence of the propaganda activities of Catholic priests in the Polish national spirit, analyzes the reaction of the authorities to it. The most resonant conflict between Catholics and Orthodox at the beginning of the twentieth century is described in detail – an episode in the town of Zelva, Volkovysk district, Grodno province. The basis of the source base of the article was made up of documents of the National Historical Archives of Belarus and the National Historical Archives of Belarus in Grodno. This article can be useful for specialists in history, students, everyone interested in the problems of religious and national relations in European countries. We see prospects for further research in this area in a comparative analysis of the situation in Belarus and other regions of Central and Eastern Europe of the 20th – 21th centuries, mixed in confessional and ethnic terms.

SARS-CoV-2 transmission potential and rural-urban disease burden disparities across Alabama, Louisiana, and Mississippi, March 2020 — May 2021

Purpose: To quantify and compare SARS-CoV-2 transmission potential across Alabama, Louisiana, and Mississippi and selected counties with populations in the 50th, 75th, and 100th percentile. Methods: To determine the time-varying reproduction number Rt of SARS-CoV-2, we applied the R package EpiEstim to the time series of daily incidence of confirmed cases. Median Rt percentage change when policies changed was determined. Linear regression was performed between log10-transformed cumulative incidence and log10-transformed population size at four time points. Results: Stay-at-home orders, face mask mandates, and vaccinations were associated with the most significant reductions in SARS-CoV-2 transmission in the three southern states. Rt across the three states decreased significantly by 20% following stay-at-home orders. We observed varying degrees of reductions in Rt across states following other policies. Rural Alabama counties experienced higher per capita cumulative cases relative to urban ones as of June 17 and October 17, 2020. Meanwhile, Louisiana and Mississippi saw the disproportionate impact of SARS-CoV-2 in rural counties compared to urban ones throughout the study period. Conclusion: State and county policies had an impact on local pandemic trajectories. The rural-urban disparities in case burden call for evidence-based approaches in tailoring health promotion interventions and vaccination campaigns to rural residents.

Impact of IRS-1 rs956115 and CYP2C19 rs4244285 Genotypes on Clinical Outcome of Patients Undergoing PCI

Background insulin receptor substrate-1 (IRS-1) rs956115 is associated with vascular risk in patients with coronary artery disease (CAD) and concomitant diabetes. CYP2C19 rs4244285 modulates clopidogrel responsiveness and predicts outcome of CAD. We designed this study to explore the association between IRS-1 rs956115, CYP2C19 rs4244285, and platelet reactivity as well as 1-year outcome in patients with CAD undergoing percutaneous coronary intervention (PCI).Methods IRS-1 rs956115, CYP2C19 rs4244285 genotypes and platelet reactivity were assessed in 1611 post-PCI patients. Major adverse cardiovascular events (MACE) which were defined as a composite of cardiovascular death, myocardial infarction and ischemic stroke over 1-year were evaluated. One-way ANOVA was used to compare the platelet reactivity among different genotypes of rs956115 and rs4244285. Multivariable Cox proportional hazard model analysis was used to estimate the association between genotypes of rs956115 and rs4244285 and risk of MACE.Results At 1 month, patients with rs956115 CG genotype had significantly lower level of residual ADP-induced platelet aggregation (PLADP) than those with CC genotype. PLADP significantly increased with the number of rs4244285 A alleles. Patients with rs956115 CG or GG genotype had a 2.09-fold higher risk of MACE than those with CC genotype (adjusted HR=2.09; 95%CI:1.04-4.19; P=0.0376), and those with rs4244285 GA genotype had a 2.19-fold higher risk than GG homozygotes (adjusted HR=2.19; 95%CI:1.13-4.24; P=0.0200). There was no significant difference in risk between AA and GG homozygotes. No interaction between rs956115 and rs4244285 was observed. Conclusions In post-PCI patients, rs956115 GG/CG and rs4244285 GA genotypes were associated with 2.09- and 2.19-fold cardiovascular risks respectively at 1-year follow-up. The effect of rs956115 appeared to be independent of known clinical predictors, while that of rs4244285 GA could be mediated by lower clopidogrel response. Trial registration: Pharmacogenetic and Pharmacokinetic Study of Clopidogrel (PPSC), NCT01968499. Registered October 17, 2013 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT01968499?term=NCT01968499&draw=1&rank=1

Octobrists and nationalists in the III and IV State Duma

The State Duma of the third and fourth convocations were represented by a wide range of factions, among which were intermediate groups, namely nationalists and Octobrists, conservative-liberal and liberal-conservative, respectively. In historical science, it is generally accepted that the only allies of the Octobrists (in the full sense of the word) were the All-Russian National Union. The purpose of the article is to determine the specifics of the relationship between Octobrists and nationalists in the III State Duma and in the Duma of the fourth convocation. The study is based on an array of sources on the work of both state dooms, as well as on articles and monographs on this issue. Based on the analysis of these sources and special literature, the main areas of activity of the two factions, the places of their rapprochement, the reasons for the separation of nationalists from the right-wing forces were identified. The work of the III State Duma is connected with the fact that not a liberal majority was formed, but the right, but at the heart of it was not the extreme right, but the October-nationalist bloc, but its stability was very controversial. The novelty of the study is a systematic and multilateral study of all the specifics of relations between the Union of October 17 and the All-Russian National Union, which may call into question the full solidarity of these factions on all issues from the III State Duma to 1917.

Society of Physicians at Kazan University. Pediatric section. Meeting on October 17, 1929

1) Dr. G.B. Myasnik and Ts. V. Haskina. Demonstration of a patient with chondrodystrophy. A 5-year-old Chuvashin boy with a symptom complex characteristic of chondrodystrophy is demonstrated, and a series of radiographs from this case is presented. Along the way, a literary review was made about this disease.Debate: pr.-Assoc. Gasul showed radiographs of a case of chondrodystrophy in an adult.