Adenosquamous Carcinoma of Gallbladder – A Case Report

Gallbladder cancer is an uncommon malignancy and majority of these carcinomas are adenocarcinomas. Adenosquamous carcinoma of gallbladder is a rare histopathological subtype of gallbladder carcinoma. It usually presents with symptoms of cholelithiasis like epigastric pain, nausea and bloating. On clinical examination, tenderness is usually present. Radiologically in most of the cases, gallstones are found leading to the diagnosis of cholelithiasis for which cholecystectomy is done. Gallbladder carcinomas are found mostly as an incidental finding on microscopic examination of cholecystectomy specimen. This disease is curable if diagnosed earlier but in most of the cases they present at advanced stages when resection is not possible and prognosis is poor. As this disease is extremely rare so published information is largely based on the case reports and case series. This is a case of 60 years old female patient who underwent cholecystectomy for cholelithiasis with incidental finding of Adenosquamous carcinoma on histopathology report.

Primary clear cell carcinoma of gallbladder arising in porcelain gallbladder

Gallbladder carcinomas (GBCs) are the most common carcinomas of the biliary tract. The clear cell variant is encountered rarely, accounting for approximately 1% of all GBCs.Due to its rarity, the exact incidence and pathogenesis of this variant are unknown. Though hyalinising cholecystitis (porcelain gallbladder) is an established risk factor for development of conventional adenocarcinomas of the gallbladder, its role in the pathogenesis of the rare variants of GBC is not well-established. The current case raises the possibility that clear cell carcinoma of the gallbladder may arise through the same pathways as conventional adenocarcinomas of the gallbladder.

A STUDY OF INCIDENTAL GALL BLADDER CARCINOMA IN PATIENTS UNDERGOING CHOLECYSTECTOMY

Gall bladder Carcinoma is one of the most common malignancy of the biliary tract. It's indolent and nonspecic clinical presentation and little occurance of pathognomonic radiological features, often hinders the diagnosis at an early stage. Most of the cases are diagnosed incidentally among patients underwent cholecystectomy. Gallbladder Carcinoma is a highly lethal disease, with only 10% patients presenting at a stage amenable to surgical resection. In this study we report incidental carcinoma of gallbladder in patients undergoing cholecystectomy in department of general surgery, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar over a period extending from December 2017 to June 2020.

Advanced primary squamous cell carcinoma of gallbladder and potential predictive biomarkers for prognosis

Gallbladder cancer is a relatively rare malignancy that is generally diagnosed at an advanced stage. Palliative chemotherapy, radiotherapy, or immunotherapy may be appropriate options for advanced gallbladder cancer, instead of radical surgery. In the present report, we describe an extremely unusual case of a 59-year-old man diagnosed with advanced primary squamous cell carcinoma of the gallbladder, according to imagological and pathological examinations. The symptoms of the patient were atypical. Preliminary data indicated that not only the systemic inflammatory biomarkers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio but also jaundice might be correlated with the prognosis. Although the patient was treated with the best supportive care, overall survival time was only about 2 months. Advanced primary squamous cell carcinoma of gallbladder is incurable and highly lethal.