critical solution temperatures
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ChemPlusChem ◽  
2021 ◽  
Author(s):  
Binoy Maiti ◽  
Mridula Nandi ◽  
Sebastián Bonardd ◽  
Lourdes Franco ◽  
Jordi Puiggalí ◽  
...  

2021 ◽  
Vol 5 (9) ◽  
pp. 240
Author(s):  
Alberto García-Peñas ◽  
Weijun Liang ◽  
Saud Hashmi ◽  
Gaurav Sharma ◽  
Mohammad Reza Saeb ◽  
...  

Recently, it was reported that the physical crosslinking exhibited by some biopolymers could provide multiple benefits to biomedical applications. In particular, grafting thermoresponsive polymers onto biopolymers may enhance the degradability or offer other features, as thermothickening behavior. Thus, different interactions will affect the different hydrogen bonds and interactions from the physical crosslinking of carboxymethyl cellulose, the lower critical solution temperatures (LCSTs), and the presence of the ions. This work focuses on the study of blends composed of poly(N-isopropylacrylamide), poly(N-ethylacrylamide), and carboxymethyl cellulose in water and water/methanol. The molecular features, thermoresponsive behavior, and gelation phenomena are deeply studied. The ratio defined by both homopolymers will alter the final properties and the gelation of the final structures, showing that the presence of the hydrophilic groups modifies the number and contributions of the diverse hydrogen bonds.


APL Materials ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 021119 ◽  
Author(s):  
Xiangze Zeng ◽  
Chengwen Liu ◽  
Martin J. Fossat ◽  
Pengyu Ren ◽  
Ashutosh Chilkoti ◽  
...  

2020 ◽  
pp. 2008123 ◽  
Author(s):  
Michael T. Cook ◽  
Peter Haddow ◽  
Stewart B. Kirton ◽  
William J. McAuley

2020 ◽  
Author(s):  
Xiangze Zeng ◽  
Chengwen Liu ◽  
Martin J. Fossat ◽  
Pengyu Ren ◽  
Ashutosh Chilkoti ◽  
...  

AbstractMany naturally occurring elastomers are intrinsically disordered proteins (IDPs) built up of repeating units and they can demonstrate two types of thermoresponsive phase behavior. Systems characterized by lower critical solution temperatures (LCST) undergo phase separation above the LCST whereas systems characterized by upper critical solution temperatures (UCST) undergo phase separation below the UCST. There is congruence between thermoresponsive coil-globule transitions and phase behavior whereby the theta temperatures above or below which the IDPs transition from coils to globules serve as useful proxies for the LCST / UCST values. This implies that one can design sequences with desired values for the theta temperature with either increasing or decreasing radii of gyration above the theta temperature. Here, we show that the Monte Carlo simulations performed in the so-called intrinsic solvation (IS) limit version of the temperature-dependent ABSINTH implicit solvation model, yields a useful heuristic for discriminating between sequences with known LCST versus UCST phase behavior. Accordingly, we use this heuristic in a supervised approach, integrate it with a genetic algorithm, combine this with IS limit simulations, and demonstrate that novel sequences can be designed with LCST phase behavior. These calculations are aided by direct estimates of temperature dependent free energies of solvation for model compounds that are derived using the polarizable AMOEBA forcefield. To demonstrate the validity of our designs, we calculate coil-globule transition profiles using the full ABSINTH model and combine these with Gaussian Cluster Theory calculations to establish the LCST phase behavior of designed IDPs.


2020 ◽  
Vol 53 (13) ◽  
pp. 5096-5104
Author(s):  
Lianlei Wen ◽  
Shaoze Zhang ◽  
Yan Xiao ◽  
Jin He ◽  
Shuang Zhu ◽  
...  

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