Microenvironmental Metabolites in the Intestine: Messengers between Health and Disease

The intestinal mucosa is a highly absorptive organ and simultaneously constitutes the physical barrier between the host and a complex outer ecosystem. Intestinal epithelial cells (IECs) represent a special node that receives signals from the host and the environment and translates them into corresponding responses. Specific molecular communication systems such as metabolites are known to transmit information across the intestinal boundary. The gut microbiota or food-derived metabolites are extrinsic factors that influence the homeostasis of the intestinal epithelium, while mitochondrial and host-derived cellular metabolites determine the identity, fitness, and regenerative capacity of IECs. Little is known, however, about the role of intrinsic and extrinsic metabolites of IECs in the initiation and progression of pathological processes such as inflammatory bowel disease and colorectal cancer as well as about their impact on intestinal immunity. In this review, we will highlight the most recent contributions on the modulatory effects of intestinal metabolites in gut pathophysiology, with a particular focus on metabolites in promoting intestinal inflammation or colorectal tumorigenesis. In addition, we will provide a perspective on the role of newly identified oncometabolites from the commensal and opportunistic microbiota in shaping response and resistance to antitumor therapy.

A Novel Method to Improve Performance of Diffusive Molecular Communication Systems with On-Off Keying Modulation

The Bit Error Rate (BER) of the diffusive molecular communication (DMC) systems employing on-off keying (OOK) modulation. We also analyze the BER of the OOK-modulated DMC systems with inter- symbol interference cancellation (ISIC). Our main motivation is to introduce alternative tools for analyzing and efficiently computing the BER of the DMC systems without or with ISIC. Specifically, for the OOK-modulated DMC systems without ISIC, we first derive an exact BER expression based on the Poisson modeling of DMC systems. Then, the Gaussian- and Gamma-approximation approaches are introduced to approximate the discrete Poisson distribution, and based on the approximation approaches, the corresponding BER expressions are derived.

Design Methodology of Passive In-Line Relays for Molecular Communication in Flow-Induced Microfluidic Channel

Molecular communication is a bioinspired communication that enables macro-scale, micro-scale and nano-scale devices to communicate with each other. The molecular communication system is prone to severe signal attenuation, dispersion and delay, which leads to performance degradation as the distance between two communicating devices increases. To mitigate these challenges, relays are used to establish reliable communication in microfluidic channels. Relay assisted molecular communication systems can also enable interconnection among various entities of the lab-on-chip for sharing information. Various relaying schemes have been proposed for reliable molecular communication systems, most of which lack practical feasibility. Thus, it is essential to design and develop relays that can be practically incorporated into the microfluidic channel. This paper presents a novel design of passive in-line relay for molecular communication system that can be easily embedded in the microfluidic channel and operate without external energy. Results show that geometric modification in the microfluidic channel can act as a relay and restore the degraded signal up-to 28%.