AbstractIn this introduction, Taylor-Pirie appraises the intersections of the ‘imaginative architecture of science and empire’ by examining how, as a fledging medical discipline at the fin de siècle, parasitology entered into significant encounters and exchanges with the literary and historical imagination. Introducing readers to Nobel Prize–winning parasitologist Ronald Ross (1857–1932), Taylor-Pirie lays the foundations for the rest of the book by examining how forms such as poetry and biography, genres such as imperial romance and detective fiction, and modes such as adventure and the Gothic together informed how tropical diseases, their parasites, and their vectors were understood in relation to race, gender, and nation. In addition to considering the contemporaneous public understanding of science, she also explores how parasitologists were often engaged in writing their own histories of the discipline, a practice that led to a predominantly white, predominantly male understanding of science that finds a legacy in gender disparities in STEM and biases in popular histories of medicine in favour of a mode of ‘heroic biography’. She provides a brief critical overview of the field of literature and science and places her methodology and the field in the context of contemporary topics like the Covid-19 pandemic, Black Lives Matter protests, and the heritage culture wars.