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2022 ◽  
Author(s):  
Sriyani padmalatha K.M ◽  
Yi-Lin Wu ◽  
Shikha Kukreti ◽  
Chang-Chun Chen ◽  
Chia-Ni Lin ◽  
...  

Abstract PurposeTo explore the dynamic changes in Quality of Life (QoL), anxiety/depression status, and body image (BI) of women who received different types of breast cancer (BC) surgery within an 8-years follow-up period.MethodsWomen with major BC surgeries were invited to complete the World Health Organization Quality of Life–Brief (WHOQOL-BREF), the European quality of life five dimensions questionnaire (EQ-5D), and a body image scale within 8 years of surgery. Kernel smoothing methods were applied to describe dynamic changes in QoL, anxiety/depression, and BI at different time points. Linear mixed effects models were constructed to identify the interaction between time, different types of surgery, and the determinants of QoL in these patients.ResultsA total of 1,803 women who had undergone a mastectomy, a modified radical mastectomy (MRM), and breast reconstruction (BR) were included. The BR group exhibited a high QoL score of WHOQOL one to five years after surgery with some fluctuations. The MRM group had comparatively stable, low QoL scores of WHOQOL items and less depressed/anxious. BR group generally showed fluctuated, lower scores of BI two years after operation, but they exhibited more anxiety/depression status after five years. Medical comorbidities, the status of anxiety/depression, and BI were the major factors influencing all domains and items of the WHOQOL BREF.ConclusionWhile MRM may decrease the likelihood of depression in patients with BC and BR would significantly improve their QoL in the first 5 years. We recommend that these findings should be considered and discussed in the patient participatory decision-making for breast surgery.


2021 ◽  
Vol 12 ◽  
Author(s):  
Liping Yang ◽  
Jing Yang ◽  
Jian He ◽  
Yan Zhou ◽  
Yangyang Zhang ◽  
...  

Background: The 2019 coronavirus (COVID-19) had caused a global pandemic and disrupted millions of lives. Cancer patients are a special group at greater risk of contracting viruses. This study aimed to evaluate the anxiety and depression status of cancer patients undergoing radiotherapy during the COVID-19 epidemic.Methods: 396 cancer patients who underwent radiotherapy were enrolled in this study. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate patient anxiety and depression, respectively. 373 cancer patients completed the questionnaires.Results: During the COVID-19 outbreak, the incidence of anxiety and depression in cancer patients were 34.9 and 33.8%, respectively. Approximately 31.4% of tumor radiotherapy patients had anxiety and depression. Based on univariate analysis, age, work status, education level, and clinical stage were related to anxiety and depression in cancer patients. Based on multiple regression analysis, age and clinical stage were related to anxiety, but only age was related to depression.Conclusions: Due to the COVID-19 pandemic, cancer patients experienced increased psychological problems. Our results have contributed to a better understanding of these psychological problems in cancer patients and provide a basis for psychological counseling and intervention.


2021 ◽  
Vol 11 (4) ◽  
pp. 473-479
Author(s):  
Walid Abdelbasset

Both diabetes mellitus (DM) and aging have an effect on gait behavior, balance, muscle performance, and other medical complications related to the development of diabetic neuropathy, hypoglycemia, hypotension, cognitive impairment, pain, disturbed proprioceptions, and polypharmacy. The main goal of the present review study was to identify risk variables for hypoglycemia-influenced falling in DM older people, to suggest protective interventions to reduce the occurrence and to explore the effect of physical exercise on falling among elderly individuals with DM. In July 2021, these keywords were used to search Google Scholar, PubMed, Embase: falling in elderly, DM complications, insulin, hypoglycemia, and physical exercise. Because falls are so common during activities, it is critical to figure out what elements influence balance and walking activity. Multi-medications, cognitive dysfunction, dementia, urinary incontinence, depression status, and hypoglycemia are just some of the issues that can affect the elements of controlling balance directly during motion. Others, such as multi-medications, cognitive dysfunction, dementia, urinary incontinence, depression status, and hypoglycemia, can affect balance control indirectly by disrupting posture mobility. Exercise training has been shown to increase body performance and reduce joint discomfort, as well as improve psychological status and quality of life, muscular strength and balance, lower the chance of falling, and improve overall health in the aged and older adults.


BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Snehal M. Pinto Pereira ◽  
Nina T. Rogers ◽  
Christine Power

Abstract Background We aim to determine whether adult retrospective report of child abuse is associated with greater risk of prospectively assessed harmful environments in childhood. We assessed possible recall basis by adult depression status. Methods At 45 years, participants of the 1958 British birth cohort (N = 9308) reported a range of abuse types (by 16 years). Prospective data, ages 7–16 years, were obtained for impoverished upbringing, hazardous conditions, anti-social behaviours and 16 years poor parent-child relationships. We estimated associations between retrospective report of child abuse and prospectively measured harm using (i) odds ratios (ORs, 95% confidence intervals) and (ii) positive predictive values (PPVs). PPVs were calculated stratified by adult depression status. Results Prevalence of retrospectively reported abuse ranged from 10.7% (psychological) to 1.60% (sexual) and 14.8% reported ≥ 1 type; prospectively recorded harm ranged from 10% (hazardous conditions/poor parent-child relationships) to 20% (anti-social behaviours). Adults retrospectively reporting abuse were more likely to have had harmful childhood environments: 52.4% had ≥ 1 indicator of harm (vs. 35.6% among others); ORsex-adjusted for poor relationships with parents was 2.98 (2.50, 3.54). For retrospectively reported (vs. none) abuse, there was a trend of increasing relative risk ratio with number of harms, from 1.75 (1.50, 2.03) for 1 to 4.68 (3.39, 6.45) for 3/4 childhood harms. The PPV of ≥ 1 prospectively recorded harm did not differ between depressed (0.58 (0.52, 0.64)) and non-depressed (0.58 (0.55, 0.61)) groups. Conclusions In a population cohort, adult retrospective report of child abuse was associated with several harms, prospectively measured from childhood to adolescence, providing support for the validity of retrospective report-based research. Findings suggest retrospectively reported child abuse is not biased by depression in adulthood.


SLEEP ◽  
2021 ◽  
Author(s):  
Yijia Zhang ◽  
Cheng Chen ◽  
Liping Lu ◽  
Kristen L Knutson ◽  
Mercedes R Carnethon ◽  
...  

Abstract Study Objectives As an antagonist of calcium (Ca), magnesium (Mg) has been implicated in the regulation of sleep. We aimed to examine the longitudinal associations of Mg intake and Ca-to-Mg intake ratio (Ca:Mg) with sleep quality and duration. Methods The study sample consisted of 3,964 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Dietary and supplementary intake of Mg were obtained using the CARDIA Dietary History at baseline (1985–1986), exam years 7 and 20. Self-reported sleep outcomes were measured at years 15 and 20. Sleep quality was rating from 1 (very good) to 5 (very bad). We categorized sleep duration to <7, 7–9, and >9 h. Generalized estimating equation was used to examine the associations of interest as repeated measures at the two time points. Results After adjustment for potential confounders, Mg intake was borderline associated with better sleep quality [highest quartile (Q4) vs. intake quartile (Q1): odds ratio (OR) = 1.23; 95% CI = 0.999, 1.50, ptrend = 0.051]. Participants in Q4 were also less likely to have short sleep (<7 h) compared to those in Q1 (OR = 0.64; 95% CI = 0.51, 0.81, ptrend = 0.012). The observed association with short sleep persisted among participants without depressive disorders (Q4 vs. Q1: OR = 0.64; 95% CI = 0.49, 0.82, ptrend < 0.001), but not among individuals with depressive disorder. Ca:Mg was not associated with either outcomes, regardless of depression status. Conclusions Mg intake was associated with both sleep outcomes in this longitudinal analysis. Randomized controlled trials with objective measures of sleep are warranted to establish the potential causal inference.


2021 ◽  
Vol 12 ◽  
Author(s):  
Vicki Bitsika ◽  
Christopher F. Sharpley ◽  
Mary E. McMillan ◽  
Emmanuel Jesulola ◽  
Linda L. Agnew

In order to evaluate the effects of specific forms of childhood maltreatment (CM) upon adult C-reactive protein (CRP) concentrations, and to further describe the potentially confounding role that recent life stress and depression hold in that relationship, 221 participants from rural Australia (M age = 44yr, SD = 17.8yr) completed self-report questionnaires and provided a blood sample. There were no sex differences in any variables across the 91 males and 130 females, but depression status did confound the association between global CM and CRP. The specific aspect of CM was identified as physical and mental health abuse, and this was significantly associated with CRP level in participants with depressive symptoms and those without. There was no significant confound from recent life stressors. Results hold implications for the diagnosis of CM-related CRP elevation and (potentially) depression.


PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0257942
Author(s):  
Banchlay Addis ◽  
Maereg Wolde ◽  
Amare Minyihun ◽  
Andualem Yalew Aschalew

Introduction Depression is a commonly overwhelming problem among patients with epilepsy which compromises their quality of life especially in developing countries. Previously limited studies were conducted using Becks Depression Inventory tool in Ethiopia. The aim of this study’s objective was to determine the prevalence of depression and associated factors among patients with epilepsy. Methods Institution based cross-sectional study was employed at the University of Gondar Comprehensive Specialized Hospital from March 01–30, 2019.A total of 370 participants were selected using an interview administered structured questionnaire. Hospital Anxiety and Depression Scale was used to assess the prevalence of depression.Multivariable logistic regression analysis was done to investigate potential predictors and variables with a P-value of < 0.05 and a 95% confidence interval were considered statistically significant. Results A total of 370 study participants participated with a response rate of 92%. From the total respondents 37% experienced depression. Perceived stigma (AOR = 3.89, CI: 2.27, 6.68), educational status (AOR = 0.48, CI: 0.25, 0.92), residence (AOR = 0.5, CI: 0.28, 0.89), frequency of seizure (AOR = 2.07, CI: 1.01, 4.23) and social support (AOR = 2.73, CI: 1.41–5.31) were significantly associated with depression status. Conclusion This study revealed that prevalence of depression among Epileptic patients was high. Perceived stigma, educational status, residence, frequency of seizure and social support were significantly associated with depression status. Thus, health care workers better to give more emphasis to patients with perceived stigma, higher number of seizure frequency and to those with poor level of social support.


2021 ◽  
Vol 4 (3) ◽  
pp. 98-103
Author(s):  
Krishna Mohandas ◽  
Prema Lalitha ◽  
S Krishna Kumar ◽  
K P Haridas

Bariatric surgery results in significant improvement in health related quality of life and depressive symptoms irrespective of the wide range of weight change. This experiment was planned to assess the incidence of depression in obese respondents and to analyse the change in depression after weight loss through bariatric surgery.To analyse the incidence of depression in obese individuals undergoing bariatric surgery and the significance of change in depression status after weight loss.The study was conducted in a multispecialty hospital having obesity clinic and bariatric surgery unit. The depression level before the study and at six months post surgery was assessed using a standard tool named Beck’s inventory. Study period was from 2015 to 2017.Respondents having BMI of 33-50 Kg/m belonging to both the genders in the age range of 18-65 years. The respondents having BMI more than 50Kg/m were excluded in this study.18 respondents who underwent bariatric surgery were included in the study. Percentage distribution, Pearson correlation coefficient, ANOVA, and Paired t test were the tools utilised in statistical analysis of the data.Schedule to assess change in nutritional status using a structured questionnaire considering anthropometric, biochemical, clinical and dietary parameters, and standard tool named Beck’s Depression Inventory, which is a tool for depression status. The surgery patients had initial Beck Score ranging from 1 to 14 indicating mild depression which on follow up reduced to 0 to 7. The weight loss in both genders were similar to each other. The change in intake of nutrients and the scores of depression were more prominent in men than that of women. Respondents pre operatively had mild mood disturbances which after weight loss, became a normal mood.Thus it can be concluded that weight loss through bariatric surgery is effective in reducing depression.


2021 ◽  
Author(s):  
Mariko Makhmutova ◽  
Raghu Kainkaryam ◽  
Marta Ferreira ◽  
Jae Min ◽  
Martin Jaggi ◽  
...  

BACKGROUND In 2017, an estimated 17.3 million adults in the US experienced at least one major depressive episode, with 35% of them not receiving any treatment. Under-diagnosis of depression has been attributed to many reasons including stigma surrounding mental health, limited access to medical care or barriers due to cost. OBJECTIVE To determine if low-burden personal health solutions, leveraging person-generated health data (PGHD), could represent a possible way to increase engagement and improve outcomes. METHODS Here we present the development of PSYCHE-D (Prediction of SeveritY CHange - Depression), a predictive model developed using PGHD from more than 4000 individuals, that forecasts long-term increase in depression severity. PSYCHE-D uses a two-phase approach: the first phase supplements self-reports with intermediate generated labels; the second phase predicts changing status over a 3 month period, up to 2 months in advance. The two phases are implemented as a single pipeline in order to eliminate data leakage, and ensure results are generalizable. RESULTS PSYCHE-D is composed of two Light Gradient Boosting Machine (LightGBM) algorithm-based classifiers that use a range of PGHD input features, including objective activity and sleep, self reported changes in lifestyle and medication, as well as generated intermediate observations of depression status. The approach generalizes to previously unseen participants to detect increase in depression severity over a 3-month interval with a sensitivity of 55.4% and a specificity of 65.3%, nearly tripling sensitivity, while maintaining specificity, versus a random model. CONCLUSIONS These results demonstrate that low-burden PGHD can be the basis of accurate and timely warnings that an individual's mental health may be deteriorating. We hope this work will serve as a basis for improved engagement and treatment of individuals suffering from depression. CLINICALTRIAL Data used to develop the model was derived from the Digital Signals in Chronic Pain (DiSCover) Project (Clintrials.gov identifier: NCT03421223)


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