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2022 ◽  
pp. 44-48
Author(s):  
М.А. ИЗДИБАЙ ◽  
А.А. КАНИБАЕВ ◽  
Э.Ж. КАБДЫЛКАНОВА

Цель исследования - определить уровень информированности среди населения как по вопросам генериков, так и о фармацевтической промышленности Казахстана. Анкета была разработана с применением системного подхода к её структуре и с соответствующими вопросами, проведён метод онлайн опроса и осуществлена обработка анкет представителей разных сфер деятельности, результаты анкетирования приведены в сравнительном аспекте с использованием диаграмм. При составлении вопросов особое внимание было уделено к вопросам касающихся предпочтений потребителей при выборе страны- производителя, а также их отношение к воспроизведенным препаратам. В публикации затрагивается тема пользы производства генериков по мнению потребителей, а также их личный опыт использования воспроизведенных препаратов. Вопросы были сгруппированы по трем блокам для более структурированного описания ответов: вводные вопросы; опыт применения; Отечественные производители. При формировании вопросов анкеты был соблюден принцип однозначности и краткости The purpose of the study was to determine the level of awareness among the population on both generics and the pharmaceutical industry in Kazakhstan. The questionnaire was developed using a systematic approach to its structure and with appropriate questions, an online survey method was conducted and questionnaires were processed by representatives of different areas of activity, the results of the survey are given in a comparative aspect with the use of charts. During the preparation of the questions, special attention was paid to the questions concerning the consumers' preferences when choosing the country of manufacture, as well as their attitude towards reproductions. The publication addresses the topic of the benefits of generic production in the opinion of consumers, as well as their personal experience of using reproduced drugs. The questions were grouped into three blocks for a more structured description of the answers: introductory questions; experience of use; and Domestic manufacturers. The principle of unambiguity and brevity was respected in the formation of the questions of the questionnaire.


Author(s):  
A. Abilov ◽  
M. Dunin ◽  
I. Pridanova ◽  
S. Ushakov ◽  
B. Seidakhmetov

Purpose: To conduct a comprehensive monitoring of bulls of different breeds in the summer in a comparative perspective to the study of protein-lipid and mineral metabolism, as well as to determine hormonal status on the content of endogenous hormones: testosterone, estradiol, cortisol and serum thyroxine per day taking seed.Materials and methods. For the first time in a Chernozem region of the Russian Federation (Voronezh region) was carried out comprehensive monitoring of bulls of red-motley Holstein (n = 16), Red-and-White (n = 8) and Simmental (n = 6) rocks in the same time of year (summer) of the protein-lipid and mineral metabolism, as well as the level of endogenous hormone (testosterone, estradiol, cortisol, thyroxine) and their cholesterol precursor in comparative aspect, immediately after taking the seed. Age range bulls ranged from 2 to 11 years. General monitoring was conducted on 23 indices of blood serum 3 rocks. The studies were conducted by modern methods, using modern equipment and reagents.Results. At Red Pied Holsteins an increase of total protein 100.45 g / L versus 92 g / l in normal (above the norm of 9.2%, as compared with red and White breed at the level of 11.3%). A similar increase in concentration in the blood of Holstein bulls red-White breed recorded on globulins, 68.87 g / l to 63 g / l in normal (above the norm of 9.3%), and with respect to the red-and-White breed 17, 6%. Also notes the high content of AST bulls red-motley Holstein against the red-and-White 18%, but within the reference range. Condition protein and lipid metabolism in sires only differed in content of creatinine, which amounted to 165.04 micromol / l against 163 mmol / l in normal, 1.6% higher as compared to the red and white breed this index was higher 18.7%. According to the content of testosterone highest rate was observed in bulls red-White breed 54.73 ± 9.51 nmol / l, is 10.2% more than in bulls red checkered-Holstein and 12.45% compared with Simmental breed. Similarly, in terms of serum cortisol - 355.60 ± 39.2 nmol / l in the red-bulls White breed that more than 2-fold compared with bulls Red Pied Holstein and Simmental. The difference is statistically significant at P ≤ 0,01. According to the content of estradiol relatively low levels recorded in the bulls of red-motley breed - 0.265 nmol / L vs. 0.301 nmol / L in red bulls-motley Holstein, and 0.332 nmol / L - Simmental, is lower by 13.6% and 25 , 3%, respectively.Conclusion. It was found that substantially all of the studied parameters in bulls 3 breeds are at reference values, and this gives grounds to assume that all of these breeds are well adapted to the conditions of Black Soil.


2021 ◽  
Vol 1 (3) ◽  
pp. 39-49
Author(s):  
Elena M. Lepisheva

The article focuses on the features of the dramatic process in Belarus and Russia, studied in a comparative aspect of the Soviet (1970s-1980s) and post-Soviet (1990s 2010s) periods. Our goal is to identify common and different in the dramaturgical systems of related literatures through the prism of thekey topos of the artistic structure of the works of Russian and Belarusian authors hero, conflict, chronotope. Methods of comparative studies (comparative analysis of the literary process), as well as historical and literary methods are used to implement the tasks set. The material includes the works of more than 200 Belarusian and Russian playwrights. Russian literature (A. Vampilov, L. Petrushevskaya, N. Kolyada) and Belarusian literature (A. Makayonok, E. Popova, A. Dudarev), separate directions (new wave of Russian dramaturgy of the 1970s-1980s), stages of dramaturgical life (new drama of the 1990s-2010s), aesthetically controversial development intentions (dramaturgical practice of netuteyshy in Belarusian post-Soviet dramaturgy) are given special attention. The scientific novelty of the research is predetermined by the fact that for the first time in literary studies, a comparative analysis of the dynamics of the dramatic process in Belarus and Russia has been undertaken for such a long time the last four decades.


2021 ◽  
Vol 25 (4) ◽  
pp. 339-345
Author(s):  
Vladimir V. Masljakov ◽  
Olga N. Pavlova ◽  
Alexandr A. Cymbal ◽  
Elena A. Pronina ◽  
Firdavshudzha P. Sultonov

Relevance. Acute bacterial prostatitis is one of the urgent problems in urology. According to the data presented in the literature, the number of men who have been diagnosed with this disease ranges from 10 to 40 %. At the same time, the main etiological factor in the development of this pathology is most often assigned to the bacterial microflora. However, most of the works are devoted to the study of the microflora in chronic prostatitis, and the state of the microflora in acute bacterial prostatitis remains insufficient. The aim of the study is to evaluate the state of prostate secretion microflora in a comparative aspect in healthy individuals and in patients with acute bacterial prostatitis. Materials and Methods. The study included a comparative analysis of microbiological cultures in prostate secretion of 30 people. All examined were divided into two groups: the first included 15 people without established urological pathology, the second - 15 people with an established diagnosis of acute bacterial prostatitis. Results and Discussion. As a result of the study, it was found that when sowing prostate secretion in persons without established pathology, the absence of microorganism growth was not observed in 60 % of observations, while in 40 % of cases, microorganisms growth was obtained. In the group of examined without established urological pathology, the growth of microorganisms of the following was noted: Escherichia coli - in 58 % of observations; Staphylococcus epidermidis - in 10 % of observations; Staphylococcus warnerii - in 6 % cases and Enterobacter spp. - in 26 %. At the same time, the number of detected microorganisms did not exceed 104 CFU/ml. At the same time, the presence of microbial associations was not recorded. In patients with acute bacterial prostatitis, the sterile prostate secret was 13,3 %, and in 86,7 % of people, microflora growth was obtained. Most often, in the group examined with acute bacterial prostatitis, Escherichia coli was obtained - in 45 % of the observations; Klebsiella spp. - in 23 % cases and Proteus spp. - in 19 %. Less often Staphylococcus epidermidis - in 8 % of observations; Enterobacter spp. - 3,2 %. Serratia spp. - 1,1 % and Staphylococcus warnerii - in 0,7 % cases were the least obtained. At the same time, 86 % of observations in this group revealed microbial associations. Conclusion . Comparison of the state of microflora of prostate secretions in healthy individuals and patients with acute bacterial prostatitis revealed that in patients with acute bacterial prostatitis, the absence of inoculated microflora in prostate secretions was 3 times less than in healthy individuals (13.3 % and 40 %, respectively.), and Escherichia coli was the most common microorganism in the group of patients with acute bacterial prostatitis.


Author(s):  
Алик Эдикович Петросян ◽  
Наталия Владимировна Чиркова ◽  
Арпине Бронислави Антонян ◽  
Артем Игоревич Архипов

Актуальность постоянных научных исследований в области пародонтологии обусловлена большой частотой воспалительно-деструктивных заболеваний пародонта среди всех возрастных групп населения во всем мире. Лечение и профилактика данной патологии является одной из наиболее сложных и трудоемких в терапевтической стоматологии. На сегодняшний день существует множество лекарственных препаратов отечественного и зарубежного производства, предназначенных для лечения воспалительных заболеваний пародонта. Чаще всего в их состав входят антисептики, противовоспалительные компоненты, ферментные и витаминные препараты. Нехватка в составе данных лекарственных средств иммунокорригирующих препаратов и адаптогенов, в дальнейшем приводят к развитию частых рецидивов. Отсутствие комплексного подхода к лечению данных заболеваний не только приводит к длительному его течению, но и не редко приводит к хронизации процесса, что явилось предпосылкой для исследования влияния стоматологического геля, модифицированного адаптогеном на ткани пародонта при лечении хронического катарального гингивита и хронического генерализованного пародонтита легкой степени. Изучение научной литературы подтверждает, что применение в медицине адаптогенов, при лечении различных заболеваний, оказывает выраженное противовоспалительное, иммуномодулирующее, вяжущее и седативное действие. Данная статья предусматривает изучение комплексного пародонтального индекса у пациентов при лечении хронического катарального гингивита и хронического генерализованного пародонтита легкой степени тяжести в сравнительном аспекте The relevance of ongoing scientific research in the field of periodontology is due to the high frequency of inflammatory and destructive periodontal diseases among all age groups of the population around the world. Treatment and prevention of this pathology is one of the most difficult and time-consuming in therapeutic dentistry. To date, there are many medicines of domestic and foreign production intended for the treatment of inflammatory periodontal diseases. Most often, they include antiseptics, anti-inflammatory components, enzyme and vitamin preparations. The lack of immunocorrecting drugs and adaptogens in the composition of these drugs, further lead to the development of frequent relapses. The lack of an integrated approach to the treatment of these diseases not only leads to its prolonged course, but also not infrequently leads to the chronization of the process, which was a prerequisite for studying the effect of a dental gel modified with an adaptogen on periodontal tissues in the treatment of chronic catarrhal gingivitis and chronic generalized periodontitis of mild degree. The study of scientific literature confirms that the use of adaptogens in medicine, in the treatment of various diseases, has a pronounced anti-inflammatory, immunomodulatory, astringent and sedative effect. This article provides for the study of the complex periodontal index in patients in the treatment of chronic catarrhal gingivitis and chronic generalized periodontitis of mild severity in a comparative aspect


Author(s):  
И.А. ЛАШНЕВА ◽  
А.А. КОСИЦИН

На основе анализа компонентного состава молока проведено изучение белковой и жировой фракций, метаболитов веществ и соматических клеток для голштинизированных черно-пестрых коров и карачаевских коз в сравнительном аспекте. Молоко коров предназначалось для переработки, а молоко коз использовалось для выкармливания козлят. В этой связи представляет интерес использование экспресс-метода инфракрасной (ИК) спектроскопии для исследования точности прогностической модели анализа молока от разных видов животных, в частности, для определения в образцах содержания жирных кислот (ЖК). Скрининг молока по 25 показателям выполняли с помощью анализатора CombiFOSS 7 DSCC. Установлено, что в молоке коз было достоверно больше жира и белка, насыщенных ЖК (69,59% против 65,67% в коровьем) и более значимых для питания человека полиненасыщенных ЖК (4,05% против 3,66% у коров). Коэффициент детерминации показал высокую значимость совокупных факторов, включенных в GLM-уравнение, для массовой доли лактозы (23,9%), короткоцепочечных ЖК (28,1%), ацетона (24,3%), бетагидроксибутирата (37,9%), точки замерзания молока (46,0%) и мочевины (85,1%). Корреляции между компонентами имели биологическую направленность, характерную для процессов синтеза молока в организме жвачных животных. Проведенный комплексный анализ показал перспективность ИК-спектров для использования как в менеджменте стада коров и коз, так и в накоплении информации для изучения генетической детерминации процессов образования молока у сельскохозяйственных животных. The protein and fat fractions, metabolites and somatic cells count for Holsteinized Black-and-White cows and Karachai goats were studied by in a comparative aspect. The cows’ milk was intended for processing, and milk of goats was used to feed the goatlet. In this regard, to use the express method of infrared (MIR) spectroscopy to study the accuracy of the predictive model for analyzing milk from different animal species, in particular, to determine the content of fatty acids (FA) was interesting. Milk screening for 25 parameters was performed using a CombiFOSS 7 DSCC analyzer. It was found that under the same paratypical conditions, there was significantly more fat and protein in goat milk, however, in terms of lactose content, milk pH values were higher in cows’ milk. Goat milk has a higher content of saturated FAs (69.59% opp. 65.67% in cow milk) and polyunsaturated FAs that are more significant for human nutrition (4.05% opp. 3.66% in cows). The determination coefficient showed the high significance of the aggregate factors included in the GLM equation for the lactose percentage (23.9%), short-chain FA (28.1%), acetone (24.3%), betahydroxybutyrate (37.9%), milk freezing point (46.0%) and urea (85.1%). The correlations between components had a biological orientation that characterized for the milk synthesis processes into the body of ruminants. The analysis showed that MIR spectra are promising for use in the management of a herd of cows and goats, and in the information accumulation for studying the genetic determination of milk processes synthesis in animals.


Vestnik ◽  
2021 ◽  
pp. 210-214
Author(s):  
А.М. Мадаминов ◽  
Ы.А. Бектенов ◽  
А.Ю. Айсаев ◽  
С.И. Турдалиев

До настоящего времени результаты лечения больных долихосигмой с длительными запорами остаются неудовлетворительными. Так при консервативном лечении долихосигмы неудовлетворительные результаты наблюдаются у 20-30% больных, а прихирургическом лечении доходит до 35-45%. Целью настоящего исследования является изучение результатов хиркргического лечения долихосигмы с длительностью запоров 7 и более дней. Материалом данного исследования являются результаты обследования и хирургического лечения 98 больных долихосигмой с длительными запорами, находившихся в отделении проктологии Национального Госпиталя при Министерстве здравоохранения Кыргызской Республики с 2001 года по 2020 год. Для уточнения диагноза кроме общеклинических методов исследования применены: пальцевое исследование прямой кишки, ректороманоскопия, сфинктерометрия, колоноскапия, ирригоскапия, пассаж бариевой взвеси по толстой кишке. Результаты хирургического лечения больных долихосигмой с длительными запорами в зависимости от вида оперативного вмешательства изучены в сравнительном аспекте. Из 98 больных 50 (51%) пациентам произведена резекция сигмовидной кишки, а 48 (49%) пациентам левосторонняя гемиколэктомия. Изучены отдаленные результаты хирургического лечения долихосигмы с длительными запорами у 79 больных. Так из 79 больных у 38 (48%) пациентов ранее была произведена левосторонняя гемиколэктомия, а у 41 (52%) - резекция сигмовидной кишки. У всех 38 больных перенесших левосторонную гемоколэктомию результаты хирургического лечения были хорошими. У этих пациентов отмечалось самостоятельный стул 1 раз в два дня, исчезли боли в левой половине живота и метиоризм. Из 41 пациента, перенесших резекцию сигмовидной кишки, у 29 (70,7%) больных результаты хирургического лечения оценены кака удовлетворительные. У этих больных улучшилось общее состояние, периодически наблюдался самостоятельный стул. А у 12(29,3%) больных, так же перенесших резекцию сигмовидной кишки, в последующем вновь отмечалось отсутствие самостоятельного стула, возникли боли в левой половине живота и метиоризм. У этих 12 больных результаты хирургического расценены как неудовлетворительные. Таким образом, сравнительный анализ результатов хирургического лечения долихосигмы с длительностью запора 7 и более дней показал преимущества левосторонней гемоколэктомии при этой патологии. Until now, the results of treatment of patients with dolichosigma with prolonged constipation remain unsatisfactory. So with the conservative treatment of dolichosigma, unsatisfactory results are observed in 20-30% of patients, and with surgical treatment it reaches 35-45%. The aim of this research is to study the results of surgical treatment of dolichosigma with constipation duration of 7 or more days. The material of this research is the results of examination and surgical treatment of 98 patients with dolichosigma with prolonged constipation, who were in the proctology department of the National Hospital under the Ministry of Health of the Kyrgyz Republic since 2001 till 2020. To clarify the diagnosis, in addition to general clinical research methods applied: digital examination of the rectum, sigmoidoscopy, sphincterometry, colonoscopy, irrigoscapia, passage of barium suspension through the colon. The results of surgical treatment of patients with dolichosigma with prolonged constipation, depending on the type of surgical intervention, were studied in a comparative aspect. From 98 patients, 50 (51%) patients underwent resection of the sigmoid colon, and 48 (49%) patients underwent left-sided hemicolectomy. The long-term results of surgical treatment of dolichosigma with prolonged constipation were studied in 79 patients. Thus, out of 79 patients, 38 (48%) patients had previously undergone left-sided hemicolectomy, and of 41 (52%) had sigmoid colon resection. In all 38 patients who underwent left-sided hemocolectomy, the results of surgical treatment were good. These patients had independent bowel movements once every two days, pain in the left abdomen and methiorism disappeared. From 41 patients who underwent resection of the sigmoid colon, in 29 (70.7%) patients, the results of surgical treatment were assessed as satisfactory. These patients have improved their general condition, periodically there was an independent bowel movements. And in 12 (29.3%) patients who also underwent resection of the sigmoid colon, subsequently, there was again a lack of independent bowel movements, and pain in the left side of abdomen and methiorism. In these 12 patients, the results of the surgical procedure were assessed as unsatisfactory. Therefore, a comparative analysis of surgical treatment results of dolichosigma with constipation duration of 7 or more days showed the advantages of left-sided hemocolectomy in this pathology.


Author(s):  
Elena Shevchenko ◽  
◽  
Olga Prokhorova ◽  
Igor Chekulay ◽  
◽  
...  

The article deals with cognitive models underlying the process of plant categorization by the speakers. Having analyzed 200 names of herbs and flowers in English, the authors differentiated three cognitive models, which the phytonyms categorization is based on: metaphoric, metonymic and propositional. It is shown that "the codes of culture", or in other words, well-known realia, are used as sources for nomination; on their basis typical cognitive models are formed. Since the names of flowers and herbs in the English language are mostly compound words, the identified cognitive models are described taking into account the action of the cognitive word-formation mechanisms of proverse and reverse. The first mechanism structure of a phytonym presupposes the direct order of compound-word components as a result of the initial word-combination integration. This word building mechanism is typical of the compound structures "adjective / verb + noun". The reversive mechanism represents the inner structure of a phytonym as a result of reverse transformation of the word-combination initial components. This type of mechanism is characteristic of the phytonyms created on the basis of the structures "noun + noun", "noun + ' + noun". The article describes the models of proverse and reverse structuring, which are typical of English phytonyms. The prospects of the research are to study the cognitive models and mechanisms underlying plant nomination in a comparative aspect based on the material of several languages.


2021 ◽  
Vol 12 (4) ◽  
Author(s):  
V. Z. Trokhymenko ◽  
M. I. Didukh ◽  
T. I. Kovalchuk ◽  
V. M. Bidenko ◽  
V. V. Zakharin

Lactose-free dairy products play a significant role in the diet of people with lactose intolerance, as they are a source of prombiotics and highly nutrients that are readily available, are in balanced proportions and do not contain milk sugar (lactose). In the manufacture of lactose-free dairy products in the technological scheme provides for the extraction of milk sugar (lactose), which can lead to deterioration of their sensory and physicochemical properties. The aim of this work was to study the comparative aspect of biotechnological features of yogurts made by traditional and lactose-free technologies and to evaluate their organoleptic and physicochemical properties. The object of the study were organic drinking yogurt with "blueberry" filler (with probiotic) 2.5 % and lactose-free organic yogurt (with probiotic) 2.5 %. According to the results of research, organic drinking yogurt with "blueberry" filler (with probiotic) 2.5 % in taste was sour milk, without foreign tastes and odors moderately sweet, with a pronounced taste of "blueberry" filler, consistency - homogeneous, tender, dense, without gas formation, with particles of fresh blueberries, which are distributed throughout the mass of yogurt, color - with a shade that is characteristic of blueberries. Organic lactose-free yogurt (with probiotic) 2.5 % had a sour taste, sour milk, without foreign tastes and odors, color - white. According to the results of physico-chemical studies of experimental samples of organic drinking yogurt with "blueberry" filler and lactose-free organic yogurt, the titratable acidity was 80 and 85 oT, active acidity 4.7 and 4.5, respectively. The mass fraction of carbohydrates in drinking yogurt with "blueberry" filler was 9.8 g / 100 g at 4.4 g / 100 g in lactose-free yogurt, including sugar 5.8 and 0 g / 100 g, respectively. Energy value and caloric content was higher in the sample of yogurt with "blueberry" filling. The conditional viscosity of the test samples was 1 min 30 sec. and 59 sec. in accordance. The degree of syneresis in the experimental samples of organic drinking yogurt with the filler "blueberry" and lactose-free organic yogurt was 55 and 45 % moisture content - 44.07 and 39.49 %, respectively.


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