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2022 ◽  
pp. 119-140
Author(s):  
Tiziano Volpentesta ◽  
Mario Miozza ◽  
Abhijeet Satwekar

Biopharmaceutical companies and health authorities continuously exchange information to provide safe and effective therapeutics. The interactions between the two require transparency and extensive documentation exchange concerning the processes which extend from the development through the manufacturing phase. The current processes rely on paper documentation, notebooks, and point-to-point electronic data interchange (EDI) for the storage of data. Thereby, generating challenges of data integrity within the internal siloed structures and the traceability of the medicinal products in the pursuit to avoid counterfeiting. With Industry 4.0 and blockchain, the authors envisioned a reinvented workflow that helps to 1) manage data integrity with decentralized trust and 2) improve the track and trace capabilities. Hence, biopharmaceutical companies can manage data in a more trustable manner while maintaining security and privacy, further enabling the external ecosystem with track and trace to ensure complete transparency until the therapeutics reach patients.


Author(s):  
A.D. Kaksin

The article is devoted to the development of a combined methodology. We are talking about the process of sociolinguistic study of the languages of small peoples. Most of these idiom languages (in Russia they are concentrated mainly in Siberia) are younger and little-studied (in relation to speech and texts). They need extensive documentation on European standards. Documentation and subsequent processing of the collected material are made using modern technical means: computer technologies and programs. We also believe that other methods of research can be applied to them, including traditional sociolinguistic ones. The article justifies the development of a combined methodology for these languages. The essence of this approach is as follows: using methods and techniques from the arsenal of sociolinguistics, it is necessary to fix specific structural characteristics. The combined presentation of the information of sociolinguistic and structural-semantic plans gives a combined description of the desired linguistic formations as idiom languages. Most idioms of Siberia (in particular, the Soyot language, the Koibal dialect of the Khakass language) have scientific descriptions, but they are not enough. In addition, these languages are not described as idioms in them. Understanding the available materials from this angle will help clarify the ways of developing the languages of small peoples in modern times.


2021 ◽  
Author(s):  
Ilias Moutsopoulos ◽  
Eleanor C Williams ◽  
Irina Mohorianu

Motivation: Bulk sequencing experiments are essential for exploring a wide range of biological questions. To bring data analysis closer to its interpretation, and facilitate both interactive, exploratory tasks and the sharing of easily accessible information, we present bulkAnalyseR, an R package that offers a seamless, customisable solution for most bulk RNAseq datasets. Results: In bulkAnalyseR, we integrate state-of-the-art approaches, without relying on extensive computational support. We replace static summary images with interactive panels to further strengthen the usability and interpretability of data. The package enables standard analyses on bulk sequencing output, using an expression matrix as the starting point (with the added flexibility of choosing subsets of samples). In an interactive web-based interface, steps such as quality checking, noise detection, inference of differential expression and expression patterns, and biological interpretation (enrichment analyses and identification of regulatory interactions), can be customised, easing the exploration and testing of hypotheses. Availability: bulkAnalyseR is available on GitHub, along with extensive documentation and usage examples (https://github.com/Core-Bioinformatics/bulkAnalyseR).


2021 ◽  
Vol 16 (1-2) ◽  
pp. 91-95
Author(s):  
Nicoleta Diaconu

The paper "The Influence of International Law on Contemporary Geopolitics", developed by Dr. Chiţu Alexandru-Cristinel is the result of documentary and research efforts carried out by the author during the internship of the doctoral thesis with the same title in the field "Law" in 2019. Publication of the doctoral thesis at the "Top Form" publishing house proves the author's intention to provide society with more information on the relationship between international law and contemporary geopolitics. The paper has a complex, interdisciplinary character, bringing together elements of international law, economic law, political science and geopolitics, being based on extensive documentation.


2021 ◽  
Vol 13 (23) ◽  
pp. 4731
Author(s):  
Whittaker Schroder ◽  
Timothy Murtha ◽  
Charles Golden ◽  
Andrew K. Scherer ◽  
Eben N. Broadbent ◽  
...  

Airborne laser scanning has proven useful for rapid and extensive documentation of historic cultural landscapes after years of applications mapping natural landscapes and the built environment. The recent integration of unoccupied aerial vehicles (UAVs) with LiDAR systems is potentially transformative and offers complementary data for mapping targeted areas with high precision and systematic study of coupled natural and human systems. We report the results of data capture, analysis, and processing of UAV LiDAR data collected in the Maya Lowlands of Chiapas, Mexico in 2019 for a comparative landscape study. Six areas of archaeological settlement and long-term land-use reflecting a diversity of environments, land cover, and archaeological features were studied. These missions were characterized by areas that were variably forested, rugged, or flat, and included pre-Hispanic settlements and agrarian landscapes. Our study confirms that UAV LiDAR systems have great potential for broader application in high-precision archaeological mapping applications. We also conclude that these studies offer an important opportunity for multi-disciplinary collaboration. UAV LiDAR offers high-precision information that is not only useful for mapping archaeological features, but also provides critical information about long-term land use and landscape change in the context of archaeological resources.


Author(s):  
Martina Bocci

A detailed analysis of the rehabilitation processes of two publicly owned buildings in Sardinia and Abruzzo is taken as a basis for describing the background, difficulties and possible future developments of raw earth as a building material in Italy. Earthen construction techniques, despite a rich tradition and extensive documentation, are still considered outdated, and their use today requires a fortunate confluence of contextual factors. Archival research, literature review and a study of manuals were coupled with an examination of urban plans and public policies, as well as interviews with experts and stakeholders. This multi-approach research shows that there is a strong need to appropriate traditional knowledge so as to translate local skills into viable solutions able to meet today’s needs. The key issue may be investment in training and dissemination. The mindset of the artisan, that of the homo faber (Sennet 2008), needs to be more widely associated with action toward sustainable local development.


Zootaxa ◽  
2021 ◽  
Vol 5063 (1) ◽  
pp. 1-95
Author(s):  
MING ZHANG ◽  
WEN-TIAN XU ◽  
THOMAS PAPE ◽  
WEN-YA PEI ◽  
DONG ZHANG

A checklist of the flesh flies occurring in Kalamaili Mountain Ungulate Nature Reserve, Xinjiang, NW China, is presented, based on material collected from 2009 to 2017. The checklist includes 18 genera and 46 species, 12 of which are new records for China. Four new species are described: Asiosarcophila kashanensis sp. nov., Miltogramma szpilai sp. nov., Sphecapatodes superciliosa sp. nov., and Sphecapatodes xinjiangensis sp. nov. Extensive documentation of the male and female habitus, details of the head, and the specialised setae of the male fore tarsus is given for all species where relevant, except for those already well illustrated in other publications. The male terminalia of almost all species of Paramacronychiinae and Sarcophaginae recorded from Kalamaili are illustrated with focus-stacked photographs.  


2021 ◽  
Vol 81 (10) ◽  
Author(s):  
◽  
Richard D. Ball ◽  
Stefano Carrazza ◽  
Juan Cruz-Martinez ◽  
Luigi Del Debbio ◽  
...  

AbstractWe present the software framework underlying the NNPDF4.0 global determination of parton distribution functions (PDFs). The code is released under an open source licence and is accompanied by extensive documentation and examples. The code base is composed by a PDF fitting package, tools to handle experimental data and to efficiently compare it to theoretical predictions, and a versatile analysis framework. In addition to ensuring the reproducibility of the NNPDF4.0 (and subsequent) determination, the public release of the NNPDF fitting framework enables a number of phenomenological applications and the production of PDF fits under user-defined data and theory assumptions.


Author(s):  
Sarah Klassen ◽  
Scott G. Ortman ◽  
José Lobo ◽  
Damian Evans

Abstract A dominant view in economic anthropology is that farmers must overcome decreasing marginal returns in the process of intensification. However, it is difficult to reconcile this view with the emergence of urban systems, which require substantial increases in labor productivity to support a growing non-farming population. This quandary is starkly posed by the rise of Angkor (Cambodia, 9th–fourteenth centuries CE), one of the most extensive preindustrial cities yet documented through archaeology. Here, we leverage extensive documentation of the Greater Angkor Region to illustrate how the social and spatial organization of agricultural production contributed to its food system. First, we find evidence for supra-household-level organization that generated increasing returns to farming labor. Second, we find spatial patterns which indicate that land-use choices took transportation costs to the urban core into account. These patterns suggest agricultural production at Angkor was organized in ways that are more similar to other forms of urban production than to a smallholder system.


2021 ◽  
Vol 27 (3(53)) ◽  
pp. 85-102
Author(s):  
Giovanni Rizzi

The article offers a concise presentation of the project linked to the Library Fund of the Pontifical Urbaniana University, namely, to study the inculturation of the Christian faith by relating the documentation on the editions of the Bible to the catechisms in the territories entrusted to the pastoral care of the Congregation for Evangelization of peoples. The vastness of the project itself is marked today by the difficulty of using more extensive documentation than that present in the Fund of the same Library. However, more limited segments of the indicated material of interest can already be identified. More specifically, the African continent shows quite a varied phenomenology of the editions of the Bible: from translations of the Latin Vulgate into local languages, to translations from English or French, themselves translations from Latin. In the post-conciliar period, the translations of the Bible from the original biblical languages emerge. This is the case of the Kinyarwanda versions of the NT (1988, 1989) and of the OT-NT in a single volume (1990, 1992), in which, alongside pastoral purposes, the results of modern biblical exegesis are evident, to the point of proposing categorizations of literary bodies of biblical literature from an interconfessional and also interreligious perspective.


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