chronic irritation
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Author(s):  
Varun Dogra ◽  
Silvi Sandhu ◽  
Ishfaq Ahmad Gilkar ◽  
Umer Mushtaq ◽  
Shyam Gupta

Background: Esophageal cancer is considered to be a one of the most lethal malignancy. Indian population have seen a lot of changes in the epidemiology of this deadly cancer. However very few studies have been done from northern India regarding the epidemiology and etiopathogenesis of this disease. Majority of esophageal cancers (about 90%) are either squamous cell or Adenocarcinoma. Any factor that causes chronic irritation and inflammation of the esophageal mucosa appears to increase the incidence of the esophageal. The aim of the study was to perform an epidemiological study and determine the various factors that are implicated in the pathogenesis of carcinoma esophagus.Methods: This study was conducted in the department of general surgery, Government Medical College, Jammu, as an observational prospective study. It took into account the patients from 2015 to 2020. A total of 23 patients of carcinoma oesophagus who presented to Outdoor patient wing of department of surgery were included in the study. After detailed history, examination and investigations, the various variables were extracted and data was processed.Results: In this study, the majority of people were from rural areas in their seventh decade of life with males: female ratio of 3:1. The majority of people complained of dysphagia and weight loss. The site of tumor was Gastroesophageal junction.Conclusions: This study emphasised the need of health education in our population, especially in young adults to lessen the risk factors for carcinoma esophagus.


2021 ◽  
Vol 160 (3) ◽  
pp. 322-324
Author(s):  
Eugene Velásquez ◽  
Emerson De-la-Rosa ◽  
Lourdes Herrera ◽  
Lucía Solé

Primary urinary bladder adenocarcinoma is not a common tumor, it comprises between 0.5 and 2% of all bladder tumors. It has been linked to bladder exstrophy, chronic irritation, and pelvic lipomatosis. Next, the case of a 62-year-old female patient with primary urinary bladder adenocarcinoma and vaginal wall invasion is presented.


Author(s):  
Shubham Pratap Durge ◽  
Anurag Anupkumar Bhattacharjee ◽  
Harshal Ramteke ◽  
Abhishek Gupta ◽  
Varun Kulkarni ◽  
...  

Renal cell carcinoma is one of the most common kidney pathologies in adults, responsible for approximately 90-95% of cases. The most common variant is clear cell accounting for 60-70% of cases, while papillary accounts for 10-15% of the cases. Diagnosis of carcinoma in the presence of staghorn calculus is seen in less than 1% of patients in recorded data. However, squamous cell carcinoma of the kidney is a rare condition usually associated with chronic irritation by a foreign body, most likely due to staghorn calculus. Here we present a case report of a 65 year old male who came with complaint of pain in the abdomen since two months associated with malaise, weight loss and fever. CT KUB was suggestive of a non-excreting enlarged left kidney with multiple calculi with abnormal cortical and periureteric lesions with encasement of adjacent vessels. Histopathological report revealed a rare case of primary squamous cell carcinoma, most probably originating from the pelvis and secondarily infiltrating the renal parenchyma and associated with nephrolithiasis and hydronephrosis. Initially the patient was managed conservatively. Later the patient underwent nephrectomy.


2021 ◽  
Vol 32 (1) ◽  
pp. 93-93
Author(s):  
V. Zh

M. Bonner (The Journ. Of the Amer. Medic. Associt. 1930, V. 94, - No. J4) reports 6 pages. primary lung cancer verified by autopsy. One. of the causes of lung cancer is chronic irritation with dust, auto. Strong gas, tobacco; chronic diseases of the lungs and bronchi, such as bronchitis, influenza, tbc, also predispose to the development of lung cancer.


2021 ◽  
pp. 44-47
Author(s):  
Chandrakala J ◽  
Sahana Srinath ◽  
Suganya G ◽  
Abhisikta Chakrabarty

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is relatively uncommon lesion presenting clinically as ulceration of the oral mucosa with a chronic course associated with delayed healing. Chronic irritation causing trauma to the oral mucosa is considered as major causative factor. The most commonly affected site of the lesion appears to be Tongue and Buccal mucosa. This lesion represents clinically as ulcer with indurated margins mimicking malignancy, causing diagnostic challenge for the dentists. Histologically characterized by breach in the epithelium exposing underlying connective tissue inltrated with dense amount of inammatory cells predominantly of eosinophils penetrating the underlying mucle. It is important to diagnose the lesion histologically to rule out malignancy and to treat appropriately. However the lesion resolves on its own or with minimal and conservative treatment. In this review we present four case series of clinically manifesting ulceroproliferative lesions on buccal mucosa and diagnosed as TUGSE,based on clinical and histopathological features.


2021 ◽  
Vol 9 (4) ◽  
pp. 625-627
Author(s):  
Dhawal Mody ◽  
Anchal Prajapati ◽  
Girish Bodhare ◽  
Vrushali Lathiya

Fibrous type gingival overgrowth is commonly seen in oral cavity and can be either benign or malignant lesions. Chronic irritation is one of the most common causes of nonneoplastic type of lesion. Focal fibrous hyperplasia also called as irritational or traumatic fibroma usually can be self limiting in nature or sometimes excision is recommended. Present case report demonstrates clinical and histological insight on the lesion.


2021 ◽  
Vol 10 (2) ◽  
pp. 1-5
Author(s):  
Camila Muñoz-Grez ◽  
◽  
Constanza Ulloa-Bequer ◽  

Introduction: Traumatic ulcerative granuloma with stromal eosinophilia is an uncommon condition of the oral mucosa with a chronic course, usually affecting the tongue. Case Report: Clinically it presents as a chronic ulcer, with raised and indurated borders, rarely presented as a tumor. Histologically it shows a diffuse mixed inflammatory infiltrate, rich in eosinophils. The etiology of this lesion is still unclear; however, chronic irritation from traumatic agents is considered a major initiating factor. In some cases, the presence of CD30+ mononuclear cells within the lesions suggest the possibility of a CD30+ lymphoproliferative disorder. This article presents a case of a traumatic ulcerative granuloma with stromal eosinophilia manifested in a 56-year-old female with a solitary ulcerated tumor inside the right cheek. Conclusion: It was diagnosed based on clinical data and histopathological features. In a brief literature review, the entity has been characterized, analyzing its etiology and nature.


Author(s):  
Archana A. Gupta ◽  
Supriya Kheur ◽  
Saranya Varadarajan ◽  
Sameena Parveen ◽  
Harisha Dewan ◽  
...  

The objective of the present article was to qualitatively and quantitatively review the association between chronic mechanical irritation and oral squamous cell carcinoma. PubMed, SCOPUS, and Web of Science databases were searched using the keyword combinations ‘chronic trauma and oral squamous cell carcinoma; chronic irritation and oral squamous cell carcinoma; chronic irritation and oral cancer; chronic trauma and oral cancer.’ Duplicates and irrelevant articles were excluded after the title and abstract screening. The full texts of the remaining articles were assessed using selection criteria. A total of 375 (PubMed-126; SCOPUS-152; WOS-97) articles were screened, and 343 duplicates and irrelevant articles were excluded. Only 9 of the remaining 32 articles met the selection criteria and were included in the qualitative analysis. Buccal mucosa and tongue, being highly prone to chronic irritation through the dental prosthesis, were the common sites for oral squamous cell carcinoma. Edentulous subjects with ill-fitting dentures were at a high risk of developing chronic irritation associated-oral squamous cell carcinoma. According to the Joanna Briggs Institute of risk assessment, eight of the nine included studies had a low risk of bias. The quantitative analysis showed a significant association (p<0.00001) between the chronic oral mucosal irritation and oral squamous cell carcinoma with an overall risk ratio of 2.56 at a confidence interval of 1.96 to 3.35. Chronic oral mucosa irritation has a significant association with oral squamous cell carcinoma, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor.


Author(s):  
Aparna Dave ◽  
Manpreet Arora ◽  
Pulin Saluja ◽  
Ishita Singhal ◽  
Priyanka Singh

Pyogenic Granulomas (PG) are reactive hyperplastic lesions that are formed in relation to some chronic irritation, physical trauma or hormonal factors. The PG may present in various clinical and histological forms. These often present as a smooth lobulated exophytic lesions and at times may show a marked resemblance to Peripheral Ossifying Fibroma (POF). However, the characteristic histologic presentation helps in differentiating both the lesions. Microscopically, presence of ossification in pyogenic granuloma is not common and could possibly indicate an altered response of the connective tissue stroma. The present case report shows occurrence of pyogenic granuloma in a 12-year-old female which on histological examination not only exhibited proliferating blood vessels, endothelial cells and inflammatory cells which are typical features of pyogenic granuloma but also exhibited areas of ossifications which are not frequently encountered in PG. It is important to explore the underlying aetiological factors that could lead to formation of such ossifications. It has been suggested that pyogenic granuloma and peripheral ossifying fibroma could represent part of same spectrum of focal reactive lesions. However, it is still considered that these two lesions are separate clinical entities and the histologic presentations are different and unique to both of them.


2021 ◽  
Author(s):  
Júlia Coutinho Cordeiro ◽  
José Gilberto de Brito Henriques

Context: Hemifacial spasm (HFS) is characterized by continuous or intermittent spasmodic movements at the facial nerve motor territory.1,2,3 It mainly affects middle- aged adults and usually occurs by compression of the facial nerve by anomalous vascular loops of the anteroinferior and vertebral cerebellar artery.2,3,4,5 The arachnoid cyst at the cerebellopontine angle (CPA) is an rare cause of HFS, especially in children. Case report: A six-year-old female patient started presenting at 18 months HFS on the right side. She was initially treated with anticonvulsant without improvement. The patient came to our care at the age of six presenting 2-3 HFS per day and remissions lasting 3-4 weeks. Image exams reveled a CPA arachnoid cyst compressing the VII and VIII nerves complex. Surgical drainage of the cyst was performed as the treatment of choice. In postoperative period, the patient presented remission of HFS, and cranial tomography showed a decrease in cyst volume. In three months, there was remission of the signs without use of any medications. Conclusions: There was no report of arachnoid cyst in CPA as a cause of HFS in children. HFS occurs probably by chronic irritation, since birth, because of the contact of arachnoid cyst in the emergence of the VII and VIII nerves complex in the PCA. Therefore, treatment was chosen according to the cause of HFS. Movement disorder as a clinical manifestation of the cyst is rare, especially in pediatric population, and should be considered as one of the diagnostic hypotheses.


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