Measuring What Matters—A Holistic Approach to Measuring Well-Being in Endometriosis

Endometriosis is a common condition which affects women in a number of ways and impairs their ability to live a full and meaningful life. Evaluative research has traditionally taken its cue from a medical approach which has forced women to choose one area of functioning as their primary concern, and tended to use a narrow definition of treatment success which ignores general well-being. While recent trials have included quality of life (QOL) measures as outcomes, these have not been able to capture the totality of the impact of the disease and its treatment on a woman's capability to do what she might want to do and be who she might want to be. A capability approach might overcome this barrier, but the available tools will need to be refined and validated in women with endometriosis before this can be integrated within everyday clinical and research practice.

The denotation and the connotation as a logic method in legal technique

The article discusses the specifics of legal techniques in the formulation of legal definition. A comparative analysis of approaches to understanding the definition procedure in jurisprudence, philosophy, logic, mathematics and philology is carried out. The relevance of the topic under study lies in the absence in modern legal tech-nology of generally accepted approaches to understanding the methodological speci-ficity of the implementation of the definition procedure. The purpose of this article is to determine the methodological foundations of differentiation of axiomatic and con-textual definitions, the implementation of the critical analysis of the classifications of types of definitions in the modern scientific literature. The basis of the concept of definition proposed by the authors is the analytical study of the logicallinguistic operation of determination on the example of the defi-nition of «corruption» from the Federal Law of December 25, 2008 No. 273-FZ. There is a lack of legal recognition of corruption as a bribe, and criticism of the narrow definition. Corruption is defined as a criminal act of a social and legal nature, which is constrained by the nature of official crimes in conflict with the interests of society and the State, the essence of which is an obvious mercenary motive in personal en-richment (material and non-material) through the use of his official position (authori-ty) for mercenary purposes. The study is based on the methodological tools of systemic, structural-functional and comparative cognition methods.

FinTechs, BigTechs and Banks—When Cooperation and When Competition?

While there is a fast-growing number of studies on FinTech, the relationships between technology companies and banks have received only limited attention in the research literature. Most of the studies on FinTech-bank interactions conducted so far address the questions: why banks collaborate with FinTechs (reasons) and how they do it (forms of cooperation), whereas this paper aims at clarifying when the most likely form of their interaction is cooperation and when competition. To cover this cognitive gap, the conceptual framework to help explain which factors affect the type of interactions between technology companies and banks is presented in this paper. Based on extensive literature review and using the market-based approach, the external factors of the market position of banks and technology companies were examined. It was found that this position and therefore the basic type of interaction depends on the adoption level of FinTechs and BigTechs in individual countries/regions. The adoption of FinTechs and BigTechs turned out to be higher in EMDEs and lower in AEs, which makes it more likely that in the first group of countries tech companies would tend to serve as banks’ competitors, whereas in the second group they would rather collaborate with banks or choose the coopetition strategy. When analyzing internal factors, the resource-based approach and a slightly modified IO theory were applied. In this part, the strategic tool which enables the assessment of the extent to which assets, skills, and features of FinTechs, BigTechs and banks are complementary (which gives the rationale for cooperation) or substitutable (which gives the rationale for competition) was proposed. This study is a critical analysis based on desk research, that contributes to the existing literature by (1) providing a narrow definition of FinTech representing the subjective/institutional approach, (2) considering separately FinTechs and BigTechs, and (3) proposing the strategic tool which helps to assess comparative advantages of banks, FinTechs and BigTechs, and thus makes it easier to choose the most appropriate type of their interaction.

Devotio and human sacrifice in archaic Italy and Rome

The Roman father and son of the same name, P. Decius Mus, became paragon heroes by deliberately giving their lives in battle that Rome might win over a fierce enemy. Both engaged in a special ritual called devotio (from which our word “devotion” derives) to offer themselves to the gods of the Underworld, with whom regular people have very little interaction and to whom they rarely sacrifice. While the Mus family is the most famous for this act, it turns out the willingness to sacrifice oneself for Rome frequently occurs within stories of great patriots, including the story of Horatius Cocles, Mettius Curtius, Atilius Regulus, and even the traitors Coriolanus and Tarpeia. Romans regarded self-sacrifice as a very high, noble endeavor, whereas they loathed and persecuted practitioners of human sacrifice. It is therefore quite amazing to read that the Romans thrice engaged in state-sponsored human sacrifice, a fact they rarely mention and generally forget. The most famous enemy practitioners of human sacrifice were the Druids, whom the Romans massacred on Mona Island on Midsummer Night's Eve, but the Carthaginians, the Germans, the Celts, and the Thracians all infamously practiced human sacrifice. To Romans, the act of human sacrifice falls just short of cannibalism in the spectrum of forbidden practices, and was an accusation occasionally thrown against an enemy to claim they are totally barbaric. On the other hand, Romans recognized their own who committed acts of self-sacrifice for the good of the society, as heroes. There can be no better patriot than he who gives his life to save his country. Often the stories of their heroism have been exaggerated or sanitized. These acts of heroism often turn out to be acts of human sacrifice, supposedly a crime. It turns out that Romans have a strong legacy of practicing human sacrifice that lasts into the historic era, despite their alleged opposition to it. Numerous sources relate one story each. Collecting them all makes it impossible to deny the longevity of human sacrifice in Rome, although most Romans under the emperors were probably unaware of it. The paradox of condemning but still practicing human sacrifice demonstrates the nature of Roman religion, where do ut des plays a crucial role in standard sacrifice as well as in unpleasant acts like human sacrifice. Devotio was an inverted form of sacrifice, precisely because it was an offering to the gods of the Underworld, rather than to Jupiter or the Parcae. Romans may have forsaken devotio, but they continued to practice human sacrifice far longer than most of us have suspected, if one widens the current narrow definition of human sacrifice to include events where a life is taken in order to bring about a better future for the commonwealth, appease the gods, or ensure a Roman victory in battle.

Digenic Inheritance: Evidence and Gaps in Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory disorder characterized by the inability to properly terminate an immune response. Familial HLH (FHLH) and related immune dysregulation syndromes are associated with mutations in the genes PRF1, UNC13D, STX11, STXBP2, LYST, AP3B1, and RAB27A, all of which are required for the assembly, exocytosis, and function of cytotoxic granules within CD8+ T cells and natural killer (NK) cells. Loss-of-function mutations in these genes render the cytotoxicity pathway ineffective, thereby failing to eradicate immune stimuli, such as infectious pathogens or malignant cells. The resulting persistent immune system stimulation drives hypercytokinemia, ultimately leading to severe tissue inflammation and end-organ damage. Traditionally, a diagnosis of FHLH requires the identification of biallelic loss-of-function mutations in one of these degranulation pathway genes. However, this narrow definition fails to encompass patients with other genetic mechanisms underlying degranulation pathway dysfunction. In particular, mounting clinical evidence supports a potential digenic mode of inheritance of FHLH in which single loss-of-function mutations in two different degranulation pathway genes cooperate to impair pathway activity. Here, we review the functions of the FHLH-associated genes within the degranulation pathway and summarize clinical evidence supporting a model in which cumulative defects along this mechanistic pathway may underlie HLH.

The better angels of our digital nature? Offensive cyber capabilities and state violence

Transformations in state violence are intimately associated with technological capacity. Like previous era-defining technologies, global digital networks have changed state violence. Offensive cyber capabilities (OCCs) appear to constitute a major technological development that offers the potential for reducing state violence. This article asks: are OCCs really the better angels of our digital nature? Current scholarship in strategic studies, adopting a narrow definition of violence, conceives of OCCs as largely non-violent. This ignores how technology has given rise to new forms of harm to individuals and communities, particularly in the context of violent state repression. We propose using an expanded definition of violence, including affective and community harms, and argue that OCCs relocate, rather than reduce, state violence towards non-bodily harms. Even though their lethal effects are limited, OCCs are not, as is supposed, a non-violent addition to state arsenals. This conclusion has important implications for international affairs, including re-orienting defensive cybersecurity efforts and altering calculations around the perception of OCCs by adversaries.

Challenging the meaning of the past from below: A typology for comparative research on memory activists

Memory activists have recently received more scholarly and public attention, but the concept lacks conceptual clarity. In this article, we articulate an analytical framework for studying memory activists, proposing a relatively narrow definition: “Memory activists” strategically commemorate the past to challenge (or protect) dominant views on the past and the institutions that represent them. Their goal is mnemonic change or to resist change. We locate scholarship on memory activists at the intersection of memory studies and social movement studies. We introduce a typology for comparative analysis of memory activism according to activist roles, temporality, and modes of interaction with other actors in memory politics, and illustrate this with a diverse set of empirical examples. We contend that the analytical utility of the concept of the “memory activist” is premised on its value-neutrality, and in particular, its application to both pro and anti-democratic cases of activism.

Are Populists Politically Intolerant? Citizens’ Populist Attitudes and Tolerance of Various Political Antagonists

Political tolerance—the willingness to extend civil rights to political antagonists—is a key democratic norm. We argue that because voters with populist attitudes have an ambiguous relationship with democracy and keep a narrow definition of the people, they are more likely to be politically intolerant. We study the Netherlands, a less likely case to find political intolerance. Using data from a representative household panel survey ( n = 1999), we investigate the extent to which populist attitudes translate into general intolerant attitudes and specific intolerance toward political antagonists. Our analyses show that voters with stronger populist attitudes are less supportive of democratic norms, more intolerant of opposing views online, and of specific political opponents. However, they are not explicitly intolerant by limiting individual civil rights or supporting intolerant measures toward political antagonists. These findings show that even in a system engrained with compromise, populist citizens show signs of political intolerance.

Energy Security in Turbulent Times Towards the European Green Deal

This article presents a theoretical approach to energy security. It incorporates the concept of governing through turbulence as both a response to crisis onset and a source of long-term policy adaptation. The article applies this framework to an empirical analysis of the energy and climate policy of the EU through a review of policy documents in the period between 1995 and 2020. The article presents the evolution in the conceptualization of energy security in EU policy from a narrow definition restricted to characteristics of energy supply to an expanded conception that integrates additional elements from associated policy areas. The article argues that the European Green Deal represents the culmination of this process and concludes that the convergence of energy and climate policy objectives reinforces the trend towards the widened conceptual scope of energy security.

How to Understand School Refusal

Attending school is usually seen as a precondition for academic, social, and emotional learning. However, school absenteeism is a problem in many countries and covers different types of authorized or unauthorized absences and a myriad of reasons. An authorized absence is when there is a satisfactory explanation for the youth’s absence, while unauthorized absence is usually understood as school attendance problems (SAPs). The main aim of this article is first to investigate define, describe, and discuss school refusal (SR) and how SR differs from other concepts of SAPs, and the secondary aim is to understand SR using different theoretical perspectives. The article outlines this aim based upon a review of international research in this field and uses the systemic integrated cognitive approach and school alienation theories to explain how SR might emerge and develop. The review indicates that SAPs involve many types, concepts, definitions, and reasons. The most frequently used concepts are school refusal behavior, truancy, school refusal, and school withdrawal. Based on the review, the article argues for a common understanding of these concepts among all stakeholders. We suggest a narrow definition of SR to enhance clarity and agreement and propose that the systemic integrated cognitive approach and school alienation theory are relevant to the understanding of SR. A common understanding among all stakeholders is the importance of identifying and intervening in specific types of SAPs. By using a systemic integrated cognitive approach and school alienation theory, identification and interventions can be targeted at an early stage of the development process of SR.