manganese porphyrins
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2021 ◽  
Author(s):  
Peter J. Gawne ◽  
Sara M. A. Pinto ◽  
Karin M. Nielsen ◽  
Mariette M. Pereira ◽  
Rafael T. M. de Rosales

Manganese porphyrins have several therapeutic/imaging applications; including their use as radioprotectants (in clinical trials), and as paramagnetic MRI contrast agents. The affinity of porphyrins for lipid bilayers also makes them candidates for cell/liposome labelling. We hypothesised that metalation with the positron emission tomography (PET) radionuclide 52Mn (t1/2 = 5.6 d) would allow long-term in vivo biodistribution studies of Mn-porphyrins as well as a method to label and track cells/liposomes, but methods for fast and efficient radiolabelling are lacking. Several porphyrins were produced and radiolabelled by addition to neutralised [52Mn]MnCl2 and heated at 165 oC for 1 h using a microwave (MW) synthesiser at a ligand concentration of 0.6 – 0.7 mM. These conditions were compared with non-MW heating at 70oC. MW radiosynthesis allowed >95 % radiochemical yields (RCY) in just 1 h. Conversely, non-MW heating at 70 oC for 1 h resulted in low RCY (0 – 25 % RCY) and most porphyrins did not reach completion after 24h. Formation of the 52Mn-complexes were confirmed with radio-HPLC by comparison with their non-radioactive 55Mn counterparts. Following this, several 52Mn-porphyrins were used to radiolabel liposomes by incubation at 50 oC for 30 min resulting in 75 – 86 % labelling efficiency (LE). Two lead 52Mn-porphyrins were taken forward to label MDA-MB-231 cancer cells in vitro, achieving ca. 11 % LE. After 24 h, 32 – 45 % of the 52Mn-porphyrin was retained in cells. In contrast to standard methods, MW heating allows fast synthesis of 52Mn-porphyrins with >95% radiochemical yields that avoid purification. 52Mn-porphyrins also show promising cell/liposome labelling properties. This technique can potentially be exploited for the in vivo imaging of Mn-porphyrin therapeutics, as well as for the accurate in vivo quantification of Mn-porphyrin MRI agents.


Author(s):  
Lucilaine Valéria de Souza Santos ◽  
Yuri Abner Rocha Lebron ◽  
Victor Rezende Moreira ◽  
Raquel Sampaio Jacob ◽  
Dayse Carvalho da Silva Martins ◽  
...  

Author(s):  
Tatyana Lomova ◽  
Yurii Tsaplev ◽  
Marija Klyueva ◽  
Ekaterina Ovchenkova

Chemosphere ◽  
2021 ◽  
Vol 268 ◽  
pp. 129334
Author(s):  
Ana Luísa Almeida Lage ◽  
Aline Capelão Marciano ◽  
Mateus Fernandes Venâncio ◽  
Mirra Angelina Neres da Silva ◽  
Dayse Carvalho da Silva Martins

2020 ◽  
pp. 223-241
Author(s):  
Katarína Valachová ◽  
Peter Rapta ◽  
Ines Batinic-Haberle ◽  
Ladislav Šoltés

2020 ◽  
Vol 59 (23) ◽  
pp. 17224-17233
Author(s):  
Tigran S. Kurtikyan ◽  
Vardan A. Hayrapetyan ◽  
Astghik A. Hovhannisyan ◽  
Garik G. Martirosyan ◽  
Gohar Sh. Hovhannisyan ◽  
...  

Polyhedron ◽  
2020 ◽  
Vol 187 ◽  
pp. 114627
Author(s):  
Alexandre Moreira Meireles ◽  
Dayse Carvalho da Silva Martins

2020 ◽  
Vol 11 ◽  
pp. 1264-1271
Author(s):  
Thomas Habets ◽  
Sylvia Speller ◽  
Johannes A A W Elemans

In a liquid-STM setup environment, the redox behavior of manganese porphyrins was studied at various solid–liquid interfaces. In the presence of a solution of Mn(III)Cl porphyrins in 1-phenyloctane, which was placed at a conductive surface, large and constant additional currents relative to a set tunneling current were observed, which varied with the magnitude of the applied bias voltage. These currents occurred regardless of the type of surface (HOPG or Au(111)) or tip material (PtIr, Au or W). The additional currents were ascribed to the occurrence of redox reactions in which chloride is oxidized to chlorine and the Mn(III) center of the porphyrin moiety is reduced to Mn(II). The resulting Mn(II) porphyrin products were identified by UV–vis analysis of the liquid phase. For solutions of Mn(III) porphyrins with non-redox active acetate instead of chloride axial ligands, the currents remained absent.


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