Optimization of Intraperitoneal Aerosolized Drug Delivery: A Computational Fluid Dynamics (CFD) and Experimental Study

Intraperitoneal (IP) aerosolized anticancer drug delivery was recently introduced in the treatment of patients with peritoneal metastases. However, little is known on the effect of treatment parameters on the spatial distribution of the aerosol droplets in the peritoneal cavity. Here, computational fluid dynamics (CFD) modeling was used in conjunction with experimental validation in order to investigate the effect of droplet size, liquid flow rate and viscosity, and the addition of an electrostatic field on the homogeneity of IP aerosol. We found that spatial distribution is optimal with small droplet sizes (1-5 µm). Using the current clinically used technology (droplet size of 30 µm), the optimal spatial distribution of aerosol is obtained with a liquid flow rate of 0.6 mL s-1. Compared to saline, nebulization of higher viscosity liquids results in less homogeneous aerosol distribution. The addition of electrostatic precipitation significantly improves homogeneity of aerosol distribution, but no further improvement is obtained with voltages higher than 6.5 kV. The results of the current study will allow to choose treatment parameters and settings in order to optimize spatial distribution of IP aerosolized drug, with a potential to enhance its anticancer effect.

Characterization of an Aerosol-Based Photobioreactor for Cultivation of Phototrophic Biofilms

Phototrophic biofilms, in particular terrestrial cyanobacteria, offer a variety of biotechnologically interesting products such as natural dyes, antibiotics or dietary supplements. However, phototrophic biofilms are difficult to cultivate in submerged bioreactors. A new generation of biofilm photobioreactors imitates the natural habitat resulting in higher productivity. In this work, an aerosol-based photobioreactor is presented that was characterized for the cultivation of phototrophic biofilms. Experiments and simulation of aerosol distribution showed a uniform aerosol supply to biofilms. Compared to previous prototypes, the growth of the terrestrial cyanobacterium Nostoc sp. could be almost tripled. Different surfaces for biofilm growth were investigated regarding hydrophobicity, contact angle, light- and temperature distribution. Further, the results were successfully simulated. Finally, the growth of Nostoc sp. was investigated on different surfaces and the biofilm thickness was measured noninvasively using optical coherence tomography. It could be shown that the cultivation surface had no influence on biomass production, but did affect biofilm thickness.

Model Sensitivity Study of the Direct Radiative Impact of Saharan Dust on the Early Stage of Hurricane Earl

Current studies report inconsistent results about the impacts of Saharan dust on the development of African Easterly Waves (AEWs), the African Easterly Jet (AEJ), and tropical cyclones (TCs). We present a modeling case study to further elucidate the direct radiative impacts of dust on the early development stage of a TC. We conducted experiments using the Weather Research and Forecasting model coupled with chemistry (WRF-Chem-V3.9.1) to simulate Hurricane Earl (2010) which was influenced by the dusty Saharan Air Layer (SAL). We used the aerosol product from ECMWF MACC-II as the initial and boundary conditions to represent aerosol distribution, along with typical model treatment of its radiative and microphysical effects in WRF. Our simulations at 36-km resolution show that, within the first 36 h, the presence of dust weakens the low-pressure system over North Africa by less than 1 hPa and reduces its mean temperature by 0.03 K. Dust weakens and intensifies the AEJ at its core and periphery, respectively, with magnitudes less than 0.2 m/s. Dust slightly shifts the position of 600 hPa AEW to the south and reduces its intensity prior to impacting the TC. Finally, TC with dust remains weaker.

Studi Pendahuluan Variasi Suhu Permukaan Laut dan Sebaran Aerosol di Laut Sawu

Research related to aerosols in Indonesia is still very minimal compared to sea surface temperature parameters and other oceanographic parameters. This study is a preliminary study that aims to determine the variation in aerosol distribution and its influence by variations in sea surface temperatures in the areas crossed by Arlindo, especially the savu sea. Savu sea surrounded by Flores islands (Sumba Regency, Kupang Regency, and Manggarai Regency) has a variation of SPL from 22 - 30 °C, where in the wetar strait, ombai strait, and sumba strait in the northwest part of sawu often occur low temperatures. While the value of aerosol spread is ranging from 0 - 0.3. Thus, a numerical model is needed that can help in analyzing the results that currently exist.

Large hemispheric difference in nucleation mode aerosol concentrations in the lowermost stratosphere at mid- and high latitudes

The details of aerosol processes and size distributions in the stratosphere are important for both heterogeneous chemistry and aerosol–radiation interactions. Using in situ, global-scale measurements of the size distribution of particles with diameters > 3 nm from the NASA Atmospheric Tomography Mission (ATom), we identify a mode of aerosol smaller than 12 nm in the lowermost stratosphere (LMS) at mid- and high latitudes. This mode is substantial only in the Northern Hemisphere (NH) and was observed in all four seasons. We also observe elevated SO2, an important precursor for new particle formation (NPF) and growth, in the NH LMS. We use box modelling and thermodynamic calculations to show that NPF can occur in the LMS conditions observed on ATom. Aircraft emissions are shown as likely sources of this SO2, as well as a potential source of nucleation mode particles directly emitted by or formed in the plume of the engines. These nucleation mode particles have the potential to grow to larger sizes and to coagulate with larger aerosol, affecting heterogeneous chemistry and aerosol–radiation interactions. Understanding all sources and characteristics of stratospheric aerosols is important in the context of anthropogenic climate change as well as proposals for climate intervention via stratospheric sulfur injection. This analysis not only adds to the, currently sparse, observations of the global impact of aviation, but also introduces another aspect of climate influence, namely a size distribution shift of the background aerosol distribution in the LMS.