keto acids
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Author(s):  
Jianting Ma ◽  
Xue Cui ◽  
Junyu Xu ◽  
Yinfeng Tan ◽  
Yan Wang ◽  
...  

Author(s):  
Shruti Rajput ◽  
Ramandeep Kaur ◽  
Nidhi Jain

Directing group assisted decarboxylative ortho-benzoylation of N-aryl-7-azaindoles with α-keto acids has been achieved by synergistic visible light promoted photoredox and palladium catalysis. The approach tenders rapid entry to aryl ketone...


Author(s):  
Yuping Zhu ◽  
Tianqi Liu ◽  
Bingxin Liu ◽  
Houguang Shi ◽  
Qitao Tan ◽  
...  

α-Keto acids were unprecedentedly employed as novel precursors of nitrile oxides on treatment with copper nitrate, which reacted with maleimides via [3+2] dipolar cycloaddition leading to pharmacologically interesting fused isoxazolines....


2021 ◽  
Author(s):  
Lihong Wang ◽  
Jiaqiong Sun ◽  
Jiuli Xia ◽  
Mingrui Li ◽  
Lianjin Zhang ◽  
...  

Alkenes are ubiquitous, and radical difunctionalization of alkenes represents one of the most practical approaches to constructing value-added compounds. Dicarbonylation of alkenes provides direct access to value-added 1,4-dicarbonyl compounds. However, selectivity control for unsymmetric 1,2-dicarbonylation is an unclosed challenge. We herein describe NHCs and photocatalysis co-catalyzed three competent radical 1,2-dicarbonylation of alkenes by distinguishing two carbonyl groups, providing structurally diversified 1,4-diketones. Mechanistic studies indicated that NHCs-stabilized ketyl-type radicals originate from aroyl fluorides via oxidative quenching process of excited photocatalysis, and acyl radicals are generated from single-electron-oxidation of α-keto acids. Distinct properties of acyl radical and NHCs-stabilized ketyl radical contributed to selectivity control. Transient acyl radicals are rapidly added to alkenes delivering alkyl radicals, which undergo subsequent radical-radical cross-coupling with ketyl-type radicals, affording 1,2-dicarbonylation products. This transformation features mild reaction conditions, broad substruct scope, and excellent selectivity, providing a general and practical approach for the dicarbonylation of olefins.


Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1343
Author(s):  
Tolga Yaman ◽  
Jeremy N. Harvey

Novel density functional theory calculations are presented regarding a mechanism for prebiotic amino acid synthesis from alpha-keto acids that was suggested to happen via catalysis by dinucleotide species. Our results were analysed with comparison to the original hypothesis (Copley et al., PNAS, 2005, 102, 4442–4447). It was shown that the keto acid–dinucleotide hypothesis for possible prebiotic amino acid synthesis was plausible based on an initial computational analysis, and details of the structures for the intermediates and transition states showed that there was wide scope for interactions between the keto acid and dinucleotide moieties that could affect the free energy profiles and lead to the required proto-metabolic selectivity.


Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7287
Author(s):  
Xiaoqing Mu ◽  
Xian Feng ◽  
Tao Wu ◽  
Feng Zhou ◽  
Yao Nie ◽  
...  

α-Amino acids and α-keto acids are versatile building blocks for the synthesis of several commercially valuable products in the food, agricultural, and pharmaceutical industries. In this study, a novel transamination-like reaction catalyzed by leucine dehydrogenase was successfully constructed for the efficient enzymatic co-synthesis of α-amino acids and α-keto acids. In this reaction mode, the α-keto acid substrate was reduced and the α-amino acid substrate was oxidized simultaneously by the enzyme, without the need for an additional coenzyme regeneration system. The thermodynamically unfavorable oxidation reaction was driven by the reduction reaction. The efficiency of the biocatalytic reaction was evaluated using 12 different substrate combinations, and a significant variation was observed in substrate conversion, which was subsequently explained by the differences in enzyme kinetics parameters. The reaction with the selected model substrates 2-oxobutanoic acid and L-leucine reached 90.3% conversion with a high total turnover number of 9.0 × 106 under the optimal reaction conditions. Furthermore, complete conversion was achieved by adjusting the ratio of addition of the two substrates. The constructed reaction mode can be applied to other amino acid dehydrogenases in future studies to synthesize a wider range of valuable products.


Biology ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1178
Author(s):  
Jackwee Lim ◽  
Duygu Sari-Ak ◽  
Tanaya Bagga

Hypersialylation is a common post-translational modification of protein and lipids found on cancer cell surfaces, which participate in cell-cell interactions and in the regulation of immune responses. Sialic acids are a family of nine-carbon α-keto acids found at the outermost ends of glycans attached to cell surfaces. Given their locations on cell surfaces, tumor cells aberrantly overexpress sialic acids, which are recognized by Siglec receptors found on immune cells to mediate broad immunomodulatory signaling. Enhanced sialylation exposed on cancer cell surfaces is exemplified as “self-associated molecular pattern” (SAMP), which tricks Siglec receptors found on leukocytes to greatly down-regulate immune responsiveness, leading to tumor growth. In this review, we focused on all 15 human Siglecs (including Siglec XII), many of which still remain understudied. We also highlighted strategies that disrupt the course of Siglec-sialic acid interactions, such as antibody-based therapies and sialic acid mimetics leading to tumor cell depletion. Herein, we introduced the central roles of Siglecs in mediating pro-tumor immunity and discussed strategies that target these receptors, which could benefit improved cancer immunotherapy.


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