OTHER'S MOTIVATION TO BRING TODDLERS TO POSYANDU TIBAN INDAH VILLAGE, SEKUPANG HEALTH CENTER WORK AREA

Background :Toddlers are a period of rapid body and brain growth in achieving optimal functions. Posyandu is a community health facility managed independently by the community. The research objective was to determine whether there was a relationship between motivation and the behavior of mothers bringing toddlers to Posyandu in the Tiban Indah Village, the working area of the Sekupang Health Center, Batam City. Toddlers are a period of rapid body and brain growth in achieving optimal functions. Posyandu is a community health facility managed independently by the community. The research objective was to determine whether the motivation of mothers to bring toddlers to Posyandu in the Tiban Indah Village, the Working Area of the Sekupang Health Center, Batam City in 2017. Method :The design of this research is a descriptive study. The population in this study were all households with toddlers aged 1-5 years as many as 1,420 children under five, with a total sample of 312 respondents, using purposive sampling technique. The research was conducted in the Sekupang Health Center, Batam City. Result : It can be seen from 312 respondents, it can be seen that as many as 130 respondents (41.7%) have high motivation, and 182 respondents (58.3%) have low motivation to visit Posyandu in Tiban Indah Village, Sekupang Health Center, Batam

Optimization of Distributed Information-Measuring Systems

The article presents the task of optimizing the information-measuring system for controlling objects with distributed parameters. The optimal control problem is formulated using the functions of distributed control (measurement). The necessary optimality conditions are obtained. Based on these conditions, a numerical algorithm for calculating the optimal functions of distributed control is constructed. Numerical experiments were carried out

Management of Ellis Class III Fracture in Two Maxillary Incisivus

Introduction. Trauma injury in the oral cavity due to collisions can cause tooth fracture. Ellis class III fracture is a fracture of the crown with an open pulp. Teeth with exposed pulp will cause irritation of the pulp resulting in pulp inflammation (pulpitis). One visit pulpectomy and jacket crown with posts were carried out to achieve optimal dental functions. Case report. A 27-year-old male patient came to Dental Hospital of Universitas Gadjah Mada complained about his broken front teeth due to accident three days earlier. The crown of the maxillary right lateral incisor and the maxillary left central incisor with open pulp was seen. The tooth 11 was avulsion, which lost at the location of accident. The diagnosis of 12 and 21 were Ellis class III fracture. Initially an infiltration anaesthesia was done, followed by one visit root canal treatment (RCT). On the second visit, the teeth were asymptomatic, hence the jacket crown preparation and fiber post insertion were performed. On the third visit, a porcelain jacket crown was cemented into teeth 12 and 21. A week later the patient came for recall and no complaints were noted. Conclusion. One visit pulpectomy followed by restoration with porcelain crown and fiber posts can be undertaken to achieve the optimal functions of teeth, namely aesthetic, mastication, phonetics, and protection of supporting tissues function.

Bioinformatic Characteristics and Therapeutic Mechanisms of Calycosin-Anti-Bisphenol A-related Osteosarcoma

BackgroundEnvironmentally, bisphenol A (BPA) is well-known as a pollutant caused human health risk, such as osteosarcoma (OS). OS, a deadly bone neoplasia, may occur in children and adults. Recently, the anti-OS pharmacotherapy prescribes limitedly. Interestingly, our previous experiments evidence that calycosin exerts the potential anti-OS action in vitro. Thus, in this report, we aimed to characterize and detail the therapeutic targets and mechanisms of calycosin-anti-BPA-related OS by means of network pharmacology and molecular docking analyses. ResultsIn details, the bioinformatic data revealed the mapped, core targets, biological functions, molecular pathways of calycosin to treat BPA-related OS. The computational analysis indicated that molecular docking ability and characteristic of core targets in calycosin to treat BPA-related OS were identified. Meanwhile, all optimal functions and pathways of calycosin-anti-BPA-related OS were revealed, as detailed in pathway networks. ConclusionsTaken together, the network pharmacology and structural biology findings illustrate the core biotargets, pharmacological functions and pathways of calycosin-anti-BPA-related OS. Potentially, these identified core targets may attribute to the scientific development of calycosin against BPA-related OS.

Symmetry Breaking of Phospholipids

Either stereo reactants or stereo catalysis from achiral or chiral molecules are a prerequisite to obtain pure enantiomeric lipid derivatives. We reviewed a few plausibly organic syntheses of phospholipids under prebiotic conditions with special attention paid to the starting materials as pro-chiral dihydroxyacetone and dihydroxyacetone phosphate (DHAP), which are the key molecules to break symmetry in phospholipids. The advantages of homochiral membranes compared to those of heterochiral membranes were analysed in terms of specific recognition, optimal functions of enzymes, membrane fluidity and topological packing. All biological membranes contain enantiomerically pure lipids in modern bacteria, eukarya and archaea. The contemporary archaea, comprising of methanogens, halobacteria and thermoacidophiles, are living under extreme conditions reminiscent of primitive environment and may indicate the origin of one ancient evolution path of lipid biosynthesis. The analysis of the known lipid metabolism reveals that all modern cells including archaea synthetize enantiomerically pure lipid precursors from prochiral DHAP. Sn-glycerol-1-phosphate dehydrogenase (G1PDH), usually found in archaea, catalyses the formation of sn-glycerol-1-phosphate (G1P), while sn-glycerol-3-phosphate dehydrogenase (G3PDH) catalyses the formation of sn-glycerol-3-phosphate (G3P) in bacteria and eukarya. The selective enzymatic activity seems to be the main strategy that evolution retained to obtain enantiomerically pure lipids. The occurrence of two genes encoding for G1PDH and G3PDH served to build up an evolutionary tree being the basis of our hypothesis article focusing on the evolution of these two genes. Gene encoding for G3PDH in eukarya may originate from G3PDH gene found in rare archaea indicating that archaea appeared earlier in the evolutionary tree than eukarya. Archaea and bacteria evolved probably separately, due to their distinct respective genes coding for G1PDH and G3PDH. We propose that prochiral DHAP is an essential molecule since it provides a convergent link between G1DPH and G3PDH. The synthesis of enantiopure phospholipids from DHAP appeared probably firstly in the presence of chemical catalysts, before being catalysed by enzymes which were the products of later Darwinian selection. The enzymes were probably selected for their efficient catalytic activities during evolution from large libraries of vesicles containing amino acids, carbohydrates, nucleic acids, lipids, and meteorite components that induced symmetry imbalance.

Symmetry Breaking of Phospholipids

Either stereo reactants or stereo catalysis from achiral or chiral molecules are prerequisite to obtain pure enantiomeric lipid derivatives. We reviewed a few plausible organic syntheses of phospholipids under prebiotic conditions with a special attention to the starting materials as pro-chiral dihydroxyacetone and dihydroxyacetone phosphate (DHAP), which are the key molecules to break symmetry in phospholipids. The advantages of homochiral membranes compared to those of heterochiral membranes were analysed in term of specific recognition, optimal functions of enzymes, membrane fluidity and topological packing. All biological membranes contain enantiomeric lipids in modern bacteria, eukarya and archaea. The contemporary archaea, comprising of methanogens, halobacteria and thermoacidophiles are living under extreme conditions reminiscent of primitive environment and may indicate the origin of one ancient evolution path of lipid biosynthesis. The analysis of lipid metabolism reveals that all modern cells including archaea synthetize enantiomeric lipid precursors from prochiral DHAP. sn-glycerol-1-phosphate dehydrogenase (G1PDH), usually found in archaea, catalyses the formation of sn-glycerol-1-phosphate (G1P), while sn-glycerol-3-phosphate dehydrogenase (G3PDH) catalyses the formation of sn-glycerol-3-phosphate (G3P) in bacteria and eukarya. The selective enzymatic activity seems to be the main strategy that evolution retained to obtain enantiomeric pure lipids. The occurrence of two genes encoding for G1PDH and G3PDH, served to build up an evolution tree and the basis of our review focusing on the evolution of these two genes. Gene encoding for G3PDH in Eukarya may originate from G3PDH gene found in rare archaea indicating that archaea appeared earlier in the evolution tree than eukarya. Archaea and bacteria evolved probably separately, due to their distinct respective genes coding for G1PDH and G3PDH. The suggested hypothesis is that catalysis of homochiral G1P or G3P from DHAP are more efficient than those leading to racemic G1P and G3P, since there are no enzymes able to synthesize racemic G1P and G3P from DHAP. We propose that G1PDH or G3DPH, which are not “image mirror enzymes” but belonging to distinct family of proteins, emerged separately during evolution. They were probably selected for their efficient catalytic activities during evolution from large libraries of vesicles containing various biopolymers, including amino acids, carbohydrates, nucleic acids, lipids, and meteorite components to induce chemical imbalance.

Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation

Engineered extracellular vesicles (EVs) carrying therapeutic molecules are promising candidates for disease therapies. Yet, engineering EVs with optimal functions is a challenge that requires careful selection of functionally specific vesicles and a proper engineering strategy. Here, we constructed chimeric apoptotic bodies (cABs) for on-demand inflammation modulation by combining pure membrane from apoptotic bodies (ABs) as a bioconjugation/regulation module and mesoporous silica nanoparticles (MSNs) as a carrier module. MSNs were preloaded with anti-inflammatory agents (microRNA-21 or curcumin) and modified with stimuli-responsive molecules to achieve accurate cargo release at designated locations. The resulting cABs actively target macrophages in the inflammatory region and effectively promote M2 polarization of these macrophages to modulate inflammation due to the synergistic regulatory effects of AB membranes and the intracellular release of preloaded cargos. This work provides strategies to arbitrarily engineer modular EVs that integrate the advantages of natural EVs and synthetic materials for various applications.

Implementasi Algoritma TEA dan Pontifex Dalam Keamanan Data File Dokumen

Data security is one of the most important aspects in information technology. With a high level of security, hopefully the information presented can be maintained its authenticity. In this final project a system that secures data and information stored on the computer from cryptanalysts is formed. The steps that the author did to make the process of forming the system include the stages of problem analysis, algorithm and flowchart along with modeling the structure of the program and design of the application interface, so that the application formed becomes easy to use and has optimal functions. By using TEA and pontifex algorithms which are secret key cryptographic algorithms, these problems can be overcome. The strength of this algorithm lies in the feistel network (including substitution operations, permutations and modular arithmetic) and delta numbers derived from the golden number.

Establishing a Genetic Algorithm-Back Propagation model to predict the pressure of girdles and to determine the model function

A Genetic Algorithm-Back Propagation (GA-BP) neural network method has been proposed to predict the clothing pressure of girdles in different postures. Firstly, a Back Propagation (BP) neural network model was used to predict the clothing pressure based on seven parameters, and three optimal functions of the model were derived. However, the prediction error 0.85411 of the network was more than the forecast requirement of 0.5 and the optimal initial weights and thresholds for the network could not be calculated. Therefore, a GA model and the BP neural network model were combined into a new GA-BP neural network model, which was used to predict the clothing pressure based on the three optimal functions. The results showed that the prediction error for this GA-BP neural network model was 0.41652, which was less than the forecast requirement of 0.5. Hence, the model was shown to predict the girdle pressure with acceptable accuracy. Finally, the internal calculation function equation for the GA-BP neural network was derived.