In recent times, cyber-attacks have been a significant problem in any organization. It can damage the brand name if confidential data is compromised. A robust cybersecurity framework should be an essential aspect of any organization. This chapter talks about the security framework for cyber threats in supply chain management and discusses in detail the implementation of a secure environment through various controls. Today, a systematic method is used for handling sensitive information in an organization. It includes processes, people, and IT systems by implementing a risk management method. Distinct controls dedicated to different levels of domains, namely human resources, access control, asset management, cryptography, physical security, operations security, supplier relations, acquisition, incident management, and security governance are provided. Companies, contractors, and any others who are part of the supply chain organization must follow this security framework to defend from any cyber-attacks.