behavior disorder
Recently Published Documents


TOTAL DOCUMENTS

1855
(FIVE YEARS 585)

H-INDEX

91
(FIVE YEARS 9)

2022 ◽  
Vol 13 ◽  
Author(s):  
Xiuqin Jia ◽  
Wentao Fan ◽  
Zhijiang Wang ◽  
Yuehong Liu ◽  
Ying Li ◽  
...  

This study aimed to explore the disrupted prefrontal cortex activity specific to patients with Parkinson's disease (PD) with rapid eye movement sleep behavior disorder (RBD) compared with those without and to further examine the associations between these alterations and neuropsychological measurements. Ninety-six patients with early PD underwent both structural and functional MRI, and also neuropsychological assessments in the Parkinson's Progression Markers Initiative (PPMI) database. Of these, 46 patients who completed 1- and 3-year fMRI follow-up examinations were categorized as PD with probable RBD (PD-pRBD+) and without (PD-pRBD−). The left dorsolateral prefrontal cortex (DLPFC) seed-to-voxel functional connectivity analysis was conducted to evaluate the progressive neural alterations specific to PD-pRBD+ compared with PD-pRBD− over time. Furthermore, relationships between these alterations and neuropsychological performance were examined. Compared with patients with PD-pRBD−, patients with PD-pRBD+ initially exhibited connectivity deficits between the left DLPFC and the medial frontopolar cortex. Moreover, these patients further exhibited disrupted DLPFC connectivity in the lateral frontopolar cortex at the 3-year follow-up evaluation. Correlation analysis revealed that connectivity between the left DLPFC and frontopolar cortex was positively related to executive function in PD-pRBD+ after adjusting for nuisance variables. Progressive prefrontal cortex dysfunction associated with RBD in early PD may provide an effective subtype-specific biomarker of neurodegenerative progression, which may shed light on the neuropathological mechanisms underlying the clinical heterogeneity of this disease.


2022 ◽  
pp. 1-7
Author(s):  
Sheida Zolfaghari ◽  
Natalia Lewandowski ◽  
Amelie Pelletier ◽  
Seyed Ali Naeimi ◽  
Jean-François Gagnon ◽  
...  

Several studies have suggested that atherosclerotic diseases and diabetes may be risk factors for α-synucleinopathies. This prospective cohort study evaluated whether cardiovascular diseases and metabolic risk factors alter the rate or type of phenoconversion from idiopathic/isolated REM sleep behavior disorder (iRBD) to parkinsonism or dementia. Polysomnography-confirmed iRBD patients recruited between 2004 and 2020 were followed annually. Baseline history of cardiovascular disorders, hypertension, hypercholesterolemia, and diabetes were compared among patients who developed outcomes versus those who remained outcome-free. No atherosclerotic risk factors were associated with development of α-synucleinopathies. Patients with hypercholesterolemia were somewhat more likely to develop dementia with Lewy bodies rather than Parkinson’s disease.


Author(s):  
Pengju Zhao ◽  
Hongguang Fu ◽  
Hui Cheng ◽  
Ruijuan Zheng ◽  
Dan Yuan ◽  
...  

Abstract Autism is a common neurodevelopmental disorder that severely affects patients’ quality of life. We aimed to investigate whether acupuncture at Zusanli (ST36) could alleviate the behavior disorder of autistic rats by inhibiting thioredoxin-interacting protein (TXNIP)-mediated activation of NLRP3. An autism model was induced by intraperitoneal injection of pregnant rats with valproic acid (VPA). The pups’ behaviors were analyzed using hot plate, open field, Morris water maze, and 3-chamber social interaction tests. Nissl staining was used to visualize neurons in prefrontal cortex. Levels of TXNIP, NLRP3, interleukin (IL)-1β, and caspase were determined by Western blot or quantitative real-time PCR. After ST36 acupuncture, pain sensitivity, autonomous activity, sociability index, sociability preference index, and learning and memory were improved in the autism model rats. Levels of TXNIP, NLRP3, IL-1β, and caspase 1 were decreased after acupuncture. Interference with TXNIP alleviated the behavior disorders and inhibited NLRP3, caspase 1, and IL-1β levels. In summary, ST36 acupuncture reduced TXNIP expression, inhibited the activation of the NLRP3 inflammasome, and alleviated the behavior disorder related to the prefrontal cortex of the autistic rats. These results point to a potential mechanism for acupuncture-induced improvement of autistic behavioral disorders.


2022 ◽  
Vol 13 ◽  
Author(s):  
Javier Oltra ◽  
Carme Uribe ◽  
Anna Campabadal ◽  
Anna Inguanzo ◽  
Gemma C. Monté-Rubio ◽  
...  

Background and Objective: Brain atrophy and cognitive impairment in neurodegenerative diseases are influenced by sex. We aimed to investigate sex differences in brain atrophy and cognition in de novo Parkinson's disease (PD) patients.Methods: Clinical, neuropsychological and T1-weighted MRI data from 205 PD patients (127 males: 78 females) and 69 healthy controls (40 males: 29 females) were obtained from the PPMI dataset.Results: PD males had a greater motor and rapid eye movement sleep behavior disorder symptomatology than PD females. They also showed cortical thinning in postcentral and precentral regions, greater global cortical and subcortical atrophy and smaller volumes in thalamus, caudate, putamen, pallidum, hippocampus, and brainstem, compared with PD females. Healthy controls only showed reduced hippocampal volume in males compared to females. PD males performed worse than PD females in global cognition, immediate verbal recall, and mental processing speed. In both groups males performed worse than females in semantic verbal fluency and delayed verbal recall; as well as females performed worse than males in visuospatial function.Conclusions: Sex effect in brain and cognition is already evident in de novo PD not explained by age per se, being a relevant factor to consider in clinical and translational research in PD.


Author(s):  
Andreas Chatzittofis ◽  
Adrian Desai E. Boström ◽  
Josephine Savard ◽  
Katarina Görts Öberg ◽  
Stefan Arver ◽  
...  

Abstract   Purpose of Review Compulsive sexual behavior disorder has been recently included in the 11th revision of the International Classification of Diseases (ICD-11), and the possible contribution of neurochemical and hormonal factors have been reported. However, relatively little is known concerning the neurobiology underlying this disorder. The aim of this article is to review and discuss published findings in the area. Recent Findings Evidence suggests that the neuroendocrine systems are involved in the pathophysiology of compulsive sexual behavior. The hypothalamus-pituitary adrenal axis, the hypothalamus-pituitary–gonadal axis, and the oxytocinergic system have been implicated. Summary Further studies are needed to elucidate the exact involvement of neuroendocrine and hormonal systems in compulsive sexual behavior disorder. Prospective longitudinal studies are particularly needed, especially those considering co-occurring psychiatric disorders and obtaining hormonal assessments in experimental circumstances with appropriate control groups.


2022 ◽  
Author(s):  
Hui Zhang ◽  
Alex Iranzo ◽  
Birgit Högl ◽  
Isabelle Arnulf ◽  
Luigi Ferini‐Strambi ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Shiyi Zhu ◽  
Zizhao Ju ◽  
Ping Wu ◽  
Fengtao Liu ◽  
Jingjie Ge ◽  
...  

The Parkinson’s Disease Progressive Neuroimaging Initiative (PDPNI) is a longitudinal observational clinical study. In PDPNI, the clinical and imaging data of patients diagnosed with Parkinsonian syndromes and Idiopathic rapid eye movement sleep behavior disorder (RBD) were longitudinally followed every two years, aiming to identify progression biomarkers of Parkinsonian syndromes through functional imaging modalities including FDG-PET, DAT-PET imaging, ASL MRI, and fMRI, as well as the treatment conditions, clinical symptoms, and clinical assessment results of patients. From February 2012 to March 2019, 224 subjects (including 48 healthy subjects and 176 patients with confirmed PDS) have been enrolled in PDPNI. The detailed clinical information and clinical assessment scores of all subjects were collected by neurologists from Huashan Hospital, Fudan University. All subjects enrolled in PDPNI were scanned with 18F-FDG PET, 11C-CFT PET, and MRI scan sequence. All data were collected in strict accordance with standardized data collection protocols.


2021 ◽  
Author(s):  
Ligang Wu ◽  
Jun Liu ◽  
Yuanyuan Li ◽  
Ying Cao ◽  
Wei Liu ◽  
...  

Abstract Background: Parkinson’s disease (PD), a severe neurodegenerative disorder, and idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD), a parasomnia recognized as the prodromal stage of synucleinopathies (including PD), both lack reliable, non-invasive biomarker tests for early intervention and management. Objectives: To investigate whether plasma extracellular vesicle (EV)-associated sncRNAs could discriminate PD and/or iRBD patients from healthy individuals.Methods: We optimized a cDNA library construction method, EVsmall-seq, for high throughput sequencing of sncRNAs associated with plasma EVs. We profiled EV-sncRNAs from the plasma of 60 normal controls, 56 iRBD patients, and 53 PD patients, and constructed a support vector machine (SVM) classifier to identify the informative miRNA features to distinguish PD and/or iRBD patients from healthy individuals. Results: First, a sixteen-miRNA signature was found to distinguish PD patients from healthy individuals with 88% sensitivity, 90.43% specificity, and 89.13% accuracy. Second, a three-miRNA signature was found to distinguish iRBD patients from healthy individuals with 96% sensitivity, 86.36% specificity, and 91.49% accuracy. Third, tweenty 20 miRNAs were found consistently increased or decreased in expression from healthy subjects to iRBD to PD patients, which might be linked to PD development through iRBD.Conclusions: Current study provides a valuable and highly informative dataset of EV-associated sncRNAs from plasma of iRBD and PD patients. We identified miRNA signature features that could serve as minimally-invasive, blood-based surveillance biomarkers for distinguishing iRBD or PD from healthy individuals with high sensitivity, specificity, and accuracy.


Sign in / Sign up

Export Citation Format

Share Document