lespedeza bicolor
Recently Published Documents


TOTAL DOCUMENTS

43
(FIVE YEARS 15)

H-INDEX

9
(FIVE YEARS 4)

Fitoterapia ◽  
2022 ◽  
pp. 105121
Author(s):  
Darya V. Tarbeeva ◽  
Natalya V. Krylova ◽  
Olga V. Iunikhina ◽  
Galina N. Likhatskaya ◽  
Anatoliy I. Kalinovskiy ◽  
...  

2020 ◽  
Vol 68 ◽  
pp. 86-89
Author(s):  
S.V. Prokopenko ◽  

A new location of the rare plant – Rhododendron schlippenbachii, listed in the Red Data Book of Russia, in the vicinity of Nakhodka City is reported. It is the most eastern point of this species in the Primorye Territory. This species was previously known only in the Khasansky district. On test area of 160 m2, with geographic coordinates N42.7849 °, E132.8204 °, in the oak forest with an undergrowth of Lespedeza bicolor at the top of the west slope registered 10 of generative plants. The plants are well developed (their sizes are 2,5 m in height, the shrub contain 3–6 skeletal branches) and bloom profusely. Found seed regeneration.


BioResources ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. 6244-6261
Author(s):  
Si Young Ha ◽  
Ji Young Jung ◽  
Hee Young Kang ◽  
Tae-Heung Kim ◽  
Jae-Kyung Yang

Lespedeza bicolor (L. bicolor) is used for medicinal purposes because of its various biological and pharmacological activities. In this study, the effects of L. bicolor ethanol extract on the treatment of vitiligo were investigated. The determination of melanin content in melanocytes was measured using B16 melanoma cells and C57BL/6J Ler-vit/vit mice. Finally, the quercetin content in L. bicolor were qualitatively analyzed using HPLC. The results obviously indicated that the L. bicolor extract enhanced melanogenesis and increased tyrosinase activity in cultured melanoma cells and C57BL/6J Ler-vit/vit mice. Treatment with L. bicolor extract led to a higher content of melanin and eumelanin in C57BL/6J Ler-vit/vit mice hair than in control (untreated) mice, which demonstrated the therapeutic effect of hair-graying associated with vitiligo. There was a notable increase in melanocytes in the skin of C57BL/6J Ler-vit/vit mice treated with L. bicolor extract compared with the control. L. bicolor extract was a potent tyrosinase and melanin synthesis activator in B16 melanoma cells. C57BL/6J Ler-vit/vit mice treated with L. bicolor extract had significantly higher melanin content in hair than the untreated control. The results suggest that L. bicolor extract is a potential alternative treatment for improvement of vitiligo.


2020 ◽  
Vol 5 (2) ◽  
pp. 1870-1871
Author(s):  
Shou-Jin Fan ◽  
Yang Yu ◽  
Wen-Qing Li ◽  
Xiu-Xiu Guo ◽  
Xiao-Jian Qu

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 451 ◽  
Author(s):  
Sergey A. Dyshlovoy ◽  
Darya Tarbeeva ◽  
Sergey Fedoreyev ◽  
Tobias Busenbender ◽  
Moritz Kaune ◽  
...  

From a root bark of Lespedeza bicolor Turch we isolated two new (7 and 8) and six previously known compounds (1–6) belonging to the group of prenylated polyphenols. Their structures were elucidated using mass spectrometry, nuclear magnetic resonance and circular dichroism spectroscopy. These natural compounds selectively inhibited human drug-resistant prostate cancer in vitro. Prenylated pterocarpans 1–3 prevented the cell cycle progression of human cancer cells in S-phase. This was accompanied by a reduced expression of mRNA corresponding to several human cyclin-dependent kinases (CDKs). In contrast, compounds 4–8 induced a G1-phase cell cycle arrest without any pronounced effect on CDKs mRNA expression. Interestingly, a non-substituted hydroxy group at C-8 of ring D of the pterocarpan skeleton of compounds 1–3 seems to be important for the CDKs inhibitory activity.


Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 148 ◽  
Author(s):  
Ji Eun Park ◽  
Heaji Lee ◽  
Sun Yeou Kim ◽  
Yunsook Lim

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia. The chronic hyperglycemic condition causes hyperinflammation via activation of nucleotide-binding oligomerization domain-like pyrin domain containing receptor 3 (NLRP3) inflammasome and abnormally leads to morphological and functional changes in kidney. A previous study showed a protective effect of Lespedeza bicolor extract (LBE) on endothelial dysfunction induced by methylglyoxal glucotoxicity. We aimed to investigate whether LBE ameliorated renal damage through regulation of NLRP3 inflammasome-dependent hyper-inflammation in T2DM mice. After T2DM induction by a high fat diet and low dose of streptozotocin (30 mg/kg), the mice were administered with different dosages of LBE (100 or 250 mg/kg/day) by gavage for 12 weeks. LBE supplementation ameliorated kidney dysfunction demonstrated by urine albumin-creatinine at a low dose and plasma creatinine, blood urea nitrogen (BUN), and glomerular hypertrophy at a high dose. Furthermore, a high dose of LBE supplementation significantly attenuated renal hyper-inflammation associated with NLRP3 inflammasome and oxidative stress related to nuclear factor erythroid 2-related factor 2 (Nrf-2) in T2DM mice. Meanwhile, a low dose of LBE supplementation up-regulated energy metabolism demonstrated by phosphorylation of adenosine monophosphate kinase (AMPK) and Sirtuin (SIRT)-1 in T2DM mice. In conclusion, the current study suggested that LBE, in particular, at a high dose could be used as a beneficial therapeutic for hyperglycemia-induced renal damage in T2DM.


Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 599 ◽  
Author(s):  
Younmi Kim ◽  
Heaji Lee ◽  
Sun Yeou Kim ◽  
Yunsook Lim

Lespedeza bicolor (LB) is one of the ornamental plants used for the treatment of inflammation caused by oxidative damage. However, its beneficial effects on hyperglycemia-induced hepatic damage and the related molecular mechanisms remain unclear. We hypothesized that Lespedeza bicolor extract (LBE) would attenuate hyperglycemia-induced liver injury in type 2 diabetes mellitus (T2DM). Diabetes was induced by a low dosage of streptozotocin (STZ) injection (30 mg/kg) with a high fat diet in male C57BL/6J mice. LBE was administered orally at 100 mg/kg or 250 mg/kg for 12 weeks. LBE supplementation regardless of dosage ameliorated plasma levels of hemoglobin A1c (HbA1c) in diabetic mice. Moreover, both LBE supplementations upregulated AMP-activation kinase (AMPK), which may activate sirtuin1 (SIRT) associated pathway accompanied by decreased lipid synthesis at low dose of LBE supplementation. These changes were in part explained by reduced protein levels of oxidative stress (nuclear factor erythroid 2-related factor 2 (Nrf2) and catalase), inflammation (nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), interleukin-6 (IL-6), and nitric oxide synthases (iNOS)), and fibrosis (α-smooth muscle actin (α-SMA) and protein kinase C (PKC)) in diabetic liver. Taken together, LBE might be a potential nutraceutical to ameliorate hepatic damage by regulation of AMPK associated pathway via oxidative stress, inflammation, and fibrosis in T2DM.


Sign in / Sign up

Export Citation Format

Share Document