Case report: Medical cannabis—warfarin drug-drug interaction

Aim A case of an 85-year-old patient with concurrent use of warfarin and medical cannabis containing delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is described. Warfarin continues to be a cornerstone of anticoagulation treatment despite the recent addition of FDA-approved anticoagulant agents. It is well known that warfarin has numerous drug interactions; however, much remains unknown about its interaction with THC and CBD. A literature review was conducted to identify documented cases of possible interactions between cannabis and warfarin. The case reports we identified noted that cannabis may potentially increase warfarin’s effect. Therefore, we aimed to determine why an effect was not seen on our patient’s warfarin dose despite daily use of medical cannabis. Case This case report describes an 85-year-old patient who despite starting an oromucosal medical cannabis regimen of THC and CBD (which provided 0.3 mg of THC and 5.3 mg CBD once daily and an additional 0.625 mg of THC and 0.625 mg CBD once daily as needed) had minimal INR fluctuations from October 2018 to September 2019. Conclusion Despite the introduction and use of medical cannabis therapy, with both THC and CBD components, an elderly patient with concurrent warfarin use did not see major INR fluctuations, in contrast to published literature. The potential for warfarin and THC/CBD interactions may be dependent on route of administration and dose of the cannabis product.

Comparing Performance of 3D-Printed and Injection-Molded Fiber-Reinforced Composite Parts in Ring-Spinning Traveler Application

Fiber-reinforced 3D printing (3DP) technology is a recent addition to the material extrusion-based 3DP process unlocking huge potential to apply this technology for high-performance material fabrication with complex geometries. However, in order to take the full advantage of this technology, a comparative analysis with existing technologies targeting a particular application is necessary to understand its commercial applicability. Here, an applied composite part, ring-spinning travelers, has been developed using the unique design features of fiber-reinforced 3DP technology that is beyond the capability of the currently used technology; the injection molding, quality, and performance of the printed and molded travelers were investigated and compared. The results demonstrated that fiber-reinforced 3DP is a promising technology that offers a lot of flexibility regarding reinforcement patterns and materials including both short and continuous fibers to tailor the performance, although the printed travelers showed poorer surface characteristics and wear resistance than the molded travelers. Based on the present analysis, a number of recommendations have been proposed on the design of the traveler to apply the technology effectively and use the printer to improvise and manipulate the performance of the travelers.

Metagenomics: A Novel Tool for Livestock and Poultry Improvement: A Review

A distinct mechanism of generating metagenome is metagenomics which includes sequencing the whole DNA extracted from an environmental sample, mapping it to a reference database followed by gene annotation. Advancement in sequence-based metagenomics has significantly reduced processing costs and has acquired a rapid pace. Metagenomics has been crucial in investigating “hidden” genetic characteristics and construction biotechnological processes through the discovery of novel genes, enzymes, pathways and bioactive molecules with entirely different or improved biochemical functions. Metagenomics is a fairly recent addition to the molecular toolbox and is the simplest, impartial way of challenging the adaptive ability of microbial populations. Metagenomics is beneficial in recognising the complex consortium of bacteria, protozoa, archaea, fungi, etc. and association amongst them resulting in higher feed utilization and productivity of animals. It allows formulating probiotics feed materials, as well as in immunomodulation in both livestock and poultry. This review emphasizes significant recent achievements in metagenomics, offers insights into the possibilities, modern-day challenges and its utility in livestock and poultry.

Archaeological Sites as Peripheral Destinations. Exploring Big Data on Fieldtrips for an Upcoming Response to the Tourism Crisis after the Pandemic

Archaeological heritage sites constitute the most recent addition to the tourism supply of Madrid, one of the most visited regions of Spain. In 2003, the Plan de Yacimientos Visitables (Plan of Archaeological Visitable Sites) was implemented, museumising 21 sites. However, the peripheral nature of these sites and the lack of personnel prevent strict control being carried out of who visits them, the practices of these visitors and how they rate the sites. This study proposes a systematic procedure to analyse the data gathered from Twitter and Flickr, in order to determine the most shared archaeological spaces in the years immediately preceding the pandemic, and to assess the perception that the visitors had of them. The information provided is useful for learning about the real weight that these sites have in leisure experiences (school trips, guided tours, recreation, etc.). Now that travel has been restricted due to the pandemic, we should ask whether Spain’s minor heritage is able to structure new proximity tourism routes. This is based on the hypothesis that, until now, these types of heritage have had a very limited role in recreational practices, but offer potential as “outdoor museums” in the present climate.

Feminist Literary Criticism Meets Feminist Theology: Yashodhara and the Rise of Hagiographical Fiction in Modern Feminist Re-visioning

Feminist re-visioning has led to heterogenous retellings of mythological heroines in fiction. Sita and Draupadi, two of the well-known Indian mythological characters, have been explored in various capacities in mythological fiction. Yashodhara, Buddha’s wife, is a recent addition to this re-visioning project. This article seeks to engage with three retellings of Yashodhara’s story—each of which is radically different from the others. The result is the rise of hagiographical fiction around the character—responsive to the Buddhist ethos of love and spirituality. This article argues that the most intriguing representations of Yashodhara found in this fiction are rooted in the nonoppositional agency given to her character.

Principles of Asian Contract Law at the Crossroads of Standardization and Legal Pluralism

The Principles of Asian Contract Law (PACL) are the most recent addition to the series of uniform laws regarding transnational commercial contracts. This time, the harmonization initiative must address the problem of a great variety of legal traditions, all of which are quite difficult to reconcile. The author focuses on the object and objectives of the PACL by reconsidering the notion of “Asian law” and the alleged cultural neutrality of contract law as a legal discipline. The paper argues that the PACL project lacks clarity. Its ambitious objectives, while apparently intelligible, fail to produce the desired results in their entirety: the Asian regional harmonization of contract law turns out to resemble its occidental forerunners. The study goes beyond the traditional comparative law. It explores the model law (in the making) in a broader context of legal policy, parallel regional private-law-making efforts in the field of contract law as well as in the context of legal globalization.

10. Duty to promote the success of the company

The Companies Act 2006 (CA 2006) s. 172(1) requires directors to act to promote the success of the company. This chapter separates that duty into its component elements: the duty to act in good faith, promoting the success of the company for the benefit of the members as a whole, having regard to stakeholders (including employees), and considering creditors’ interests. The position of a nominee director in this scheme is considered. The pluralist debate which preceded the enactment of s 172 is addressed as well as the recent addition of further reporting obligations in order to strengthen the provision. The new s 172 statement is considered. The chapter explores in detail the evolving jurisprudence around s 172(3) and the need to have regard to creditors’ interest in certain circumstances.

NCCN Guidelines® Insights: Uterine Neoplasms, Version 3.2021

The NCCN Guidelines for Uterine Neoplasms provide recommendations for diagnostic workup, clinical staging, and treatment options for patients with endometrial cancer or uterine sarcoma. These NCCN Guidelines Insights focus on the recent addition of molecular profiling information to aid in accurate diagnosis, classification, and treatment of uterine sarcomas.

Should we conduct correspondence study field experiments with political elites?

Correspondence study field experiments with political elites are a recent addition to legislative studies research, in which unsolicited emails are sent to elites to gauge their responsiveness. In this article, we discuss their ethical implications. We advance from the viewpoint that correspondence study field experiments involve trade-offs between costs and benefits that need to be carefully weighted. We elaborate this argument with two contributions in mind. First, we synthesize ethical considerations in published work to explore what the specific trade-offs are and how they can be mitigated by experimental design. We conclude that correspondence study field experiments with political elites are worth pursuing given their potential to further good governance. But they also involve distinct trade-offs that are particularly challenging. Second, we draw from our own considerations while designing a comparative correspondence study field experiment and stress challenges resulting from cross-national designs. In sum, we aim to facilitate further reasoned discussion on an important methodological issue.

Fasting Gastrointestinal Tract: Changes in Structure, Functions and Microbiota Milieu

Short and Intermittent fasting brings many structural and functional changes in the GI tract.Now it has been shown that changes are beneficial in terms of postponing the onset of NCDs prolonging the healthage,That might be the reason for Ancient Indian saints todo fasting. These benefits have been described in a series of research papers by us and others. Change in microbiota due to fasting is a recent addition which explains the mechanism of many physiological processes taking place during fasting.Two other parameters namely, effect of long and short term fasting and.sexual dimorphism on microbiota also dealt with in this review.