Social Response to the Vaccine against COVID-19: The Underrated Power of Influence

Background: The Coronavirus Disease 2019 (COVID-19) pandemic has highlighted the need for preventive medicine and vaccinology to be paralleled to eliminate COVID-19 cases. Methods: A web-based questionnaire was disseminated through social media in the late November assessing the factors that may have influenced the final response to vaccination against COVID-19 in vaccinated and non-vaccinated Greek people. Results: Women, the younger generations, and university graduates were more likely to accept vaccination, whereas men, those with a basic education level, and the older generation showed a hesitance to the vaccine against COVID-19. About half of the vaccinated participants were influenced in their final decision mainly by being informed from the internet (50.4%), their work (51.7%), and social life (53,1%) while half of the non-vaccinated individuals were mostly influenced by keeping updated from the internet (55.5%) and by government policies (51.3%). COVID-19 risk (OR 2.511; CI 2.149–2.934; p = 0.000), frequent vaccinations for emerging pathogens (OR 14.022; CI 11.998-16.389), and social life (OR 2.828; CI 2.417–3.309; p = 0.000) had a significant impact on people’s positive response to vaccination against COVID-19. Conclusions: Monitoring and assessing the influence factors for the response to vaccination can be favourable strategies to further manage societal vaccination rates.

Analyzing Parametric Sensitivity on the Cyclic Behavior of Steel Shear Walls

As a destructive phenomenon in most parts of the world, earthquake has threatened the safety of structures and the lives of its inhabitants and is considered as the main problem in the seismic vulnerability of buildings. Steel shear walls are regarded as one of the newest structural systems resistant to lateral load in steel structures. The present study aimed to investigate the impact of effective parameters on cyclic behavior by numerically modeling a steel shear wall and comparing it with laboratory results. The results indicated the significant contribution of the thickness of steel shear sheet so that when the thickness changes to 25%, the final response of the structure increased by approximately 20% and decreased by 15%.

Harnessing the Wisdom of the Confident Crowd in Medical Image Decision-making

Improving the accuracy of medical image interpretation is critical to improving the diagnosis of many diseases. Using both novices (undergraduates) and experts (medical professionals), we investigated methods for improving the accuracy of a single decision maker and a group of decision makers by aggregating repeated decisions in different ways. Participants made classification decisions (cancerous versus non-cancerous) and confidence judgments on a series of cell images, viewing and classifying each image twice. We first examined whether it is possible to improve individual-level performance by using the maximum confidence slating algorithm (Koriat, 2012b), which leverages metacognitive ability by using the most confident response for an image as the ‘final response’. We find maximum confidence slating improves individual classification accuracy for both novices and experts. Building on these results, we show that aggregation algorithms based on confidence weighting scale to larger groups of participants, dramatically improving diagnostic accuracy, with the performance of groups of novices reaching that of individual experts. In sum, we find that repeated decision making and confidence weighting can be a valuable way to improve accuracy in medical image decision-making and that these techniques can be used in conjunction with each other.

Learning Repetition, but not Syllable Reversal

Reduplication is common, but analogous reversal processes are rare, even though reversal, which involves nested rather than crossed dependencies, is less complex on the Chomsky hierarchy. We hypothesize that the explanation is that repetitions can be recognized when they match and reactivate a stored trace in short-term memory, but recognizing a reversal requires rearranging the input in working memory before attempting to match it to the stored trace. Repetitions can thus be recognized, and repetition patterns learned, implicitly, whereas reversals require explicit, conscious awareness. To test these hypotheses, participants were trained to recognize either a reduplication or a syllable-reversal pattern, and then asked to state the rule. In two experiments, above-chance classification performance on the Reversal pattern was confined to Correct Staters, whereas above-chance performance on the Reduplication pattern was found with or without correct rule-stating. Final proportion correct was positively correlated with final response time for the Reversal Correct Staters but no other group. These results support the hypothesis that reversal, unlike reduplication, requires conscious, time-consuming computation.

Interfacing aptamers, nanoparticles and graphene in a hierarchical structure for highly selective detection of biomolecules in OECT devices

In several biomedical applications, the detection of biomarkers demands high sensitivity, selectivity and easy-to-use devices. Organic electrochemical transistors (OECTs) represent a promising class of devices combining a minimal invasiveness and good signal transduction. However, OECTs lack of intrinsic selectivity that should be implemented by specific approaches to make them well suitable for biomedical applications. Here, we report on a biosensor in which selectivity and a high sensitivity are achieved by interfacing, in an OECT architecture, a novel gate electrode based on aptamers, Au nanoparticles and graphene hierarchically organized to optimize the final response. The fabricated biosensor performs state of the art limit of detection monitoring biomolecules, such as thrombin-with a limit of detection in the picomolar range (≤ 5 pM) and a very good selectivity even in presence of supraphysiological concentrations of Bovine Serum Albumin (BSA-1mM). These accomplishments are the final result of the gate hierarchic structure that reduces sterich indrance that could contrast the recognition events and minimizes false positive, because of the low affinity of graphene towards the physiological environment. Since our approach can be easily applied to a large variety of different biomarkers, we envisage a relevant potential for a large series of different biomedical applications.

Supercritical Carbon Dioxide Extraction of Phenolic Compounds from Potato (Solanum tuberosum) Peels

In the last three decades, greener technologies have been used, aiming at extracting phenolic compounds from vegetable matrices due to the inherent advantages compared to organic solvent-based methodologies. In this work, supercritical CO2 was investigated for recovering phenolic acids from potato peels. Following screening runs for assessing the significant extraction parameters, a Central Composite Design of Experiments was carried out aiming at process optimization, with methanol concentration (MeOH, %) and CO2 flow rate (qCO2, g/min) as independent variables. Both parameters were deemed to impart a significant effect on the final response. Although the major phenolic acid in potato peels is chlorogenic acid (CGA), the main compound extracted was caffeic acid (CFA), present at a concentration of 0.75 mg/g dry peel in the extracts. The optimum extraction conditions were 80 °C, 350 bar, MeOH 20%, and flow rate of 18.0 g/min, which enabled a total phenolic recovery of 37% and a CFA recovery of 82%. The antioxidant activity of the supercritical fluid extraction (SFE) extracts was also measured, with the highest scavenging capacity reaching 73%. The need for using mixtures of water and organic solvents as co-solvents in SFE to enable CGA recovery seems necessary, possibly due to its better dissolution in aqueous solutions than in pure solvents.

A Collaborative Approach to Manuscript Revisions and Responses to Reviewer Comments

While there are benefits to collaborative research, navigating group dynamics can also bring challenges, particularly for doctoral students and early career academics who are new to the research process. These dynamics extend beyond initial manuscript submission and include processes associated with interpreting reviewer comments, deciding upon and making revisions, and developing clear author response documents through the revision process. Herein, the authors overview one systematic and replicable approach to managing revisions. Steps include (a) read, set aside, and return to the reviewer comments; (b) document initial reactions to comments; (c) collectively review the comments and decide upon direction; (d) coordinate revisions to the manuscript; (e) craft final response statements; and (f) prepare a resubmission cover letter to the editor. Recommendations will be provided for approaching the revision, including how to revise the manuscript to highlight edits, and suggestions for tone and approach, particularly when disagreeing with a reviewer.

University Students’ Awareness about Oral Health and Hygiene

Objective: The objective of the study was to evaluate the awareness of university students about oral health and hygiene in a university in Malaysia. Methods: A cross-sectional study was conducted among the students of four different faculties (pharmacy, medical, biotechnology and business) in a university in Malaysia with the help of pre-validated research questionnaire. The Statistical Package for Social Science (SPSS) Version 24.0 was used to analyze and present the data. Results: The final response gathered was 324 from four faculties. The pharmacy faculty students had better knowledge as compared to the other faculties. The female students had better knowledge of oral health hygiene as compared to males. Final year students reported more appropriate knowledge as compared to pre-final year students. Conclusion: Overall appropriate knowledge was observed among the four studied faculties of the university. The present study concluded that pharmacy students had more appropriate knowledge of oral health and hygiene than the other faculty students.