polypyridyl complexes
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2022 ◽  
Author(s):  
Yasmine S Zubi ◽  
Bingqing Liu ◽  
Yifan Gu ◽  
Dipankar Sahoo ◽  
Jared C Lewis

Visible light photocatalysis enables a broad range of organic transformations that proceed via single electron or energy transfer. Metal polypyridyl complexes are among the most commonly employed visible light photocatalysts....


2022 ◽  
Vol 529 ◽  
pp. 120637
Author(s):  
Kalai Selvan Karumban ◽  
Arabinda Muley ◽  
Bishnubasu Giri ◽  
Sadananda Kumbhakar ◽  
Tatinaidu Kella ◽  
...  

2022 ◽  
Author(s):  
Isadora Tisoco ◽  
Maria Carolina Donatoni ◽  
Henrique Victória ◽  
José Roberto de Toledo ◽  
Klaus Krambrock ◽  
...  

We report the synthesis and characterization of two novel tetra-cationic porphyrins, containing Pt(II) or Pd(II) polypyridyl complexes attached at the peripheral position of N4-macrocycle. Compounds were characterized through elemental analysis,...


2022 ◽  
Author(s):  
Olga Mazuryk ◽  
Ewelina Janczy-Cempa ◽  
Justyna Lagosz ◽  
Dorota Rutkowska-Zbik ◽  
Agata Machnicka ◽  
...  

The purpose of this study was to investigate a correlation between the spectroscopic and photophysical properties of Ru(II) polypyridyl complexes and their photodynamic activity in vitro. A series of Ru(II)...


2021 ◽  
Author(s):  
Yasmine S. Zubi ◽  
Bingqing Liu ◽  
Yifan Gu ◽  
Dipankar Sahoo ◽  
Jared Lewis

Visible light photocatalysis enables a broad range of organic transformations that proceed via single electron or energy transfer. Metal polypyridyl complexes are among the most commonly employed visible light photocatalysts. The photophysical properties of these complexes have been extensively studied and can be tuned by modifying the substituents on the pyridine ligands. On the other hand, ligand modifications that enable substrate binding to control reaction selectivity remain rare. Given the exquisite control that enzymes exert over electron and energy transfer processes in nature, we envisioned that artificial metalloenzymes (ArMs) created by incorporating Ru(II) polypyridyl complexes into a suitable protein scaffold could provide a means to control photocatalyst properties. This study describes approaches to create covalent and non-covalent ArMs from a variety of Ru(II) polypyridyl cofactors and a prolyl oligopeptidase scaffold. A panel of ArMs with enhanced photophysical properties were engineered, and the nature of the scaffold/cofactor interactions in these systems was investigated. These ArMs provided higher yields and rates than Ru(Bpy)32+ for the reductive cyclization of dienones and the [2+2] photocycloaddition between C-cinnamoyl imidazole and 4-methoxystyrene, suggesting that protein scaffolds could provide a means to improve the efficiency of visible light photocatalysts.


2021 ◽  
Vol 14 (10) ◽  
pp. 1014
Author(s):  
Przemysław Gajda-Morszewski ◽  
Ilona Gurgul ◽  
Ewelina Janczy-Cempa ◽  
Olga Mazuryk ◽  
Michał Łomzik ◽  
...  

Primary tumor targeting is the dominant approach in drug development, while metastasis is the leading cause of cancer death. Therefore, in addition to the cytotoxic activity of a series of Ru(II) polypyridyl complexes of the type [Ru(dip)2L]2+ (dip: 4,7-diphenyl-1,10-phenanthroline while L = dip; bpy: 2,2′-bipyridine; bpy-SC: bipyridine derivative bearing a semicarbazone 2-formylopyridine moiety; dpq, dpq(CH3)2, dpb: quinoxaline derivatives) their ability to inhibit cell detachment was investigated. In vitro studies performed on lung cancer A549 cells showed that they accumulate in cells very well and exhibit moderate cytotoxicity with IC50 ranging from 4 to 13 µM. Three of the studied compounds that have dip, bpy-SC, or dpb ligands after treatment of the cells with a non-toxic dose (<1/2IC50) enhanced their adhesion properties demonstrated by lower detachment in the trypsin resistance assay. The same complexes inhibited both MMP-2 and MMP-9 enzyme activities with IC50 ranging from 2 to 12 µM; however, the MMP-9 inhibition was stronger. More detailed studies for [Ru(dip)2(bpy-SC)]2+, which induced the greatest increase in cell adhesion, revealed that it is predominately accumulated in the cytoskeletal fraction of A549 cells. Moreover, cells treated with this compound showed the localization of MMP-9 to a greater extent also in the cytoskeleton. Taken together, our results indicate the possibility of a reduction of metastatic cells escaping from the primary lesion to the surrounding tissue by prevention of their detachment and by influencing the activity of MMP-2 and MMP-9.


2021 ◽  
Vol 115 ◽  
pp. 105290 ◽  
Author(s):  
Huiwen Zhang ◽  
Li Tian ◽  
Rongxing Xiao ◽  
Yi Zhou ◽  
Yuanyuan Zhang ◽  
...  

Author(s):  
Małgorzata Brindell ◽  
Ilona Gurgul ◽  
Ewelina Janczy-Cempa ◽  
Przemysław Gajda-Morszewski ◽  
Olga Mazuryk

2021 ◽  
pp. 117788
Author(s):  
Prashant Kumar ◽  
Falguni Chandra ◽  
Paltan Laha ◽  
Kavyashree P ◽  
Srikanta Patra ◽  
...  

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