The Effectiveness of Topical Drugs with a Personalized Approach in the Treatment of Chronic Dermatoses

At the present time, dermatologists’ arsenal has been significantly enriched with new highly effective drugs able to improve significantly the treatment of chronic immune-dependent dermatoses, in particular – atopic dermatitis and microbial eczema. The article discusses topical external agents for the treatment of patients with chronic dermatoses.

Efficacy of acupuncture for melasma: a protocol of systematic review and meta-analysis

Review question / Objective: How effective is acupuncture in treating melasma compared to conventional treatment？ Condition being studied: Melasma is a common acquired hyperpigmentation of the skin. The clinical manifestations are light brown or dark brown patches symmetrically distributed on the cheeks, forehead and mandibular with different shades and unclear borders. Melasma particularly affects women during menstruation, especially in thirties and forties Asian women. The incidence of Asian women of childbearing age is as high as 30%. Current treatments for melasma include topical drugs, chemical peeling agents, laser and light treatments, and systemic drugs. Despite the strong demand for treatment, the treatment of melasma is still very challenging, the results are inconsistent, and the recurrence rate is almost constant.

EFEKTIVITAS PENGGUNAAN ASAM TRANEKSAMAT ORAL PADA PASIEN MELASMA

This study aims to determine the effectiveness of using oral tranexamic acid in melasma patients, as well as to explain the definition of melasma, melasma epidemiology, melasma etiopathogenesis, and to explain the effectiveness of using oral tranexamic acid in melasma. The method used was to collect and analyze research articles on the effectiveness of the use of oral tranexamic acid topical drugs in Melasma patients. The articles are obtained through a search using Google Scholar, Pubmed. The term melasma comes from the Greek word "melas" which means black. Clinically melasma appears as macules or brown spots. Complaints of melasma usually occur symmetrically. The areas of melasma predilection are most commonly the cheeks, upper lip, chin and forehead, but can also be affected in other areas. (Debabrata, Handel et al., 2014). Research conducted for 6 months by Sufan et al ,. It is known that after therapy using Tranexamic Acid, there was a decrease in hyperpigmentation. After 6 months of treatment, the results were very good (10.8%, 8/74), good (54%, 40/74), moderate (31.1%, 23/74), and bad (4.1%). , 3/74). There were 4 patients (5.4%) who experienced mild gastrointestinal discomfort, 6 patients (8.1%) hypomenorrhea, subjects who rarely reported skin rash due to allergies as well as dizziness, alopecia, drowsiness and hyposexuality. From these results it is concluded that oral Tranexmatic Acid has good effectiveness in melasma therapy. (Sufan et al., 2012). From the results of this study it can be concluded that Tranexamic Acid has good effectiveness in the therapy of melasma. Where there are several risk factors that cause melasma, which can occur due to genetic factors, UV exposure, hormonal factors and inflammatory factors. Tranexamic acid will inhibit the action of tyrosinase activity by blocking the interaction of melanocytes and keratinocytes through inhibition of the plasminogen system. Keywords: Melasma, treatment for melasma, epidemiologi, etiologi, tranexamic acid,.

Antipruritic therapy issues on background of skin xerosis

The relationship of xerosis with various skin diseases is very multifaceted, at the same time, xerosis can be the cause of the onset or aggravation of itching. Modern recommendations for the external treatment of chronic dermatoses, accompanied by xerosis and itching, imply two directions: direct therapeutic measures during an exacerbation and the use of dermatocosmetics adapted to certain symptoms.Material and methods. We observed 26 patients (mean age 38.7 ± 1.9 years with atopic dermatitis, eczema, psoriasis or pruritus, where xerosis was present in the clinical picture and pruritus was noted. All patients used topical drugs in accordance with the nosology, in as an adjuvant therapy – Neotanin Comfort Plus cream.Research results. In atopic dermatitis, the corneometry index increased by an average of 21%, with eczema – by 20%, with psoriasis – by 22%, with skin itching – by 12%. Transepidermal water loss decreased in atopic dermatitis by 19.8%, with eczema – by 22.8%, with psoriasis – by 21.8%, with pruritus – by 18.4% The value of the total BRS index decreased by more than two times.Conclusion. The use of Neotanin Comfort Plus cream in combination with topical drug therapy (GCS, multicomponent drugs) is highly effective and safe in patients with atopic dermatitis, eczema, psoriasis or pruritus, which makes it possible to recommend it for use in wide clinical practice.

How to relieve a baby’s teething pain?

Teething of temporary teeth in children is a natural and physiological process. However, in some cases, it can be accompanied by numerous unpleasant symptoms, such as fever, decreased appetite, anxiety in the child, sleep disturbance and indigestion. Knowledge of the physiology of teething, anatomical and physiological characteristics and factors affecting the process of teething of temporary teeth in children is important for the timely provision of assistance to such children. The article describes in detail the duration of teething, mechanisms, age and constitutional peculiarities during teething, the causes of pathological teething (dentitio difficiLis). The authors provided symptoms and differential diagnosis of delayed eruption of the teeth - the teething syndrome and presented methods and techniques for reducing pain intensity. The advantages and disadvantages of the main drugs that are used to treat the teething syndrome are also outlined: anti-infLammatory drugs (acetaminophen, ibuprofen), topical drugs (gels, ointments), homeopathic preparations. Particular attention is paid to the advantages of homeopathic combination preparations, which are highly effective, safe and provide a minimal pharmacological Load on the child’s body. CLinicaL cases of children aged 6.5 months and 8 months with teething symptoms and the use of a homeopathic combination preparation are presented. Positive changes were observed: heaLth improvement, anxiety reLief, fever reLief, appetite improvement. This case has demonstrated how non-drug measures, mother support and homeopathic preparations can effectiveLy heLp treat the baby’s teething syndrome without using non-steroidaL anti-infLammatory drugs and topicaL preparations.

A case report of asymptomatic cutaneous larva migrans

<p>Cutaneous larvae migrans or creeping eruption is a serpiginous cutaneous eruption caused by the accidental penetration and migration of animal hookworm (nematode) larvae through the epidermis and subcutaneous tissue. The infection occurs most frequently in warmer climates and is associated with pruritus and burning sensation<span style="text-decoration: line-through;">s</span>. We report a case of 48 years old farmer with vesicular lesion on left ankle progressing into a serpiginous track on the skin surface without any characteristic symptoms. Treatment with oral and topical drugs led to successful resolution of lesions within 10 days.</p>

Nanoemulsions: A Review on the Conceptualization of Treatment for Psoriasis Using a ‘Green’ Surfactant with Low-Energy Emulsification Method

Psoriasis is a skin disease that is not lethal and does not spread through bodily contact. However, this seemingly harmless condition can lead to a loss of confidence and social stigmatization due to a persons’ flawed appearance. The conventional methods of psoriasis treatment include taking in systemic drugs to inhibit immunoresponses within the body or applying topical drugs onto the surface of the skin to inhibit cell proliferation. Topical methods are favored as they pose lesser side effects compared to the systemic methods. However, the side effects from systemic drugs and low bioavailability of topical drugs are the limitations to the treatment. The use of nanotechnology in this field has enhanced drug loading capacity and reduced dosage size. In this review, biosurfactants were introduced as a ‘greener’ alternative to their synthetic counterparts. Glycolipid biosurfactants are specifically suited for anti-psoriatic application due to their characteristic skin-enhancing qualities. The selection of a suitable oil phase can also contribute to the anti-psoriatic effect as some oils have skin-healing properties. The review covers the pathogenic pathway of psoriasis, conventional treatments, and prospective ingredients to be used as components in the nanoemulsion formulation. Furthermore, an insight into the state-of-the-art methods used in formulating nanoemulsions and their progression to low-energy methods are also elaborated in detail.

A comparative study of efficacy of oral itraconazole, terbinafine and fluconazole: a clinical trial

<p class="abstract"><strong>Background:</strong> Keeping in view the rising number of cases of dermatophyte infections and also poor response to topical drugs, this study was conducted with the intention to arrive at a conclusion regarding the best available systemic drug.</p><p class="abstract"><strong>Methods:</strong> A total of 270 patients were selected for the study. 90 patients were assigned to each group under itraconazole, terbinafine &amp; fluconazole.<strong></strong></p><p class="abstract"><strong>Results:</strong> It was found that itraconazole was the most effective drug which led to a considerable decrease in erythema, peripheral spread, scaling and spread to other body sites. Next drug to be the most effective was terbinafine, which was followed by fluconazole.</p><p class="abstract"><strong>Conclusions:</strong> We finally arrived at a conclusion that itraconazole is the most effective drug for all types of superficial fungal infections. It was followed by terbinafine &amp; fluconazole in terms of drug effectiveness. Hence in this study we advocate the use of itraconazole as first line of drug in all patients of tinea infections.</p><p class="abstract"> </p>