The Effect of Caregiver Key Opinion Leaders on Increasing Caregiver Demand for Evidence-Based Practices to Treat Youth Anxiety: Protocol for a Randomized Control Trial

Background:Research has identified cognitive behavioral therapy with exposures (CBT) as an effective treatment for youth anxiety. Despite implementation efforts, few anxious youth receive CBT. Direct-to-consumer marketing offers a different approach to address the unmet need for youth receiving effective treatments. Involving a local caregiver key opinion leader in direct-to-consumer initiatives may be an effective strategy to increase caregiver demand for CBT. Research indicates that key opinion leaders improve health promotion campaigns, but key opinion leaders have not been studied in the context of increasing caregiver demand for evidence-based treatments.Method:Project CHAT (Caregivers Hearing about Anxiety Treatments) will test the role of key opinion leader participation in conducting outreach presentations to increase caregiver desire to seek CBT for their youth’s anxiety. Caregiver attendees (N = 180) will be cluster-randomized by school to receive one of two different approaches for presentations on CBT for youth anxiety. Both approaches will involve community outreach presentations providing information on recognizing youth anxiety, strategies caregivers can use to decrease youth anxiety, and how to seek CBT for youth anxiety. The researcher-only condition will be co-facilitated by two researchers. In the key opinion leader condition, a caregiver key opinion leader from each local community will be involved in tailoring the content of the presentation to the context of the community, co-facilitating the presentation with a researcher, and endorsing strategies in the presentation that they have found to be helpful. In line with the theory of planned behavior, caregiver attendees will complete measures assessing their knowledge of, attitudes towards, perceived subjective norms about, and intention to seek CBT pre- and post-presentation; they will indicate whether they sought CBT for their youth at three-month follow-up. Results will be analyzed using a mixed method approach to assess the effectiveness of a key opinion leader to increase caregiver demand for CBT.Discussion:This study will be the first to examine the potential of key opinion leaders to increase caregiver demand for CBT. If proven effective, the use of key opinion leaders could serve as a scalable dissemination strategy to increase the reach of evidence-based treatments.Trial registration:This trial was registered on clinicaltrials.gov (NCT04929262) on June 18, 2021. At the time of trial registration, pre/post presentation data had been collected from 17 participants; thus, it was retrospectively registered.

The effect of caregiver key opinion leaders on increasing caregiver demand for evidence-based practices to treat youth anxiety: protocol for a randomized control trial

Background Research has identified cognitive behavioral therapy with exposures (CBT) as an effective treatment for youth anxiety. Despite implementation efforts, few anxious youth receive CBT. Direct-to-consumer marketing offers a different approach to address the unmet need for youth receiving effective treatments. Involving a local caregiver key opinion leader in direct-to-consumer initiatives may be an effective strategy to increase caregiver demand for CBT. Research indicates that key opinion leaders improve health promotion campaigns, but key opinion leaders have not been studied in the context of increasing caregiver demand for evidence-based treatments. Method Project CHAT (Caregivers Hearing about Anxiety Treatments) will test the role of key opinion leader participation in conducting outreach presentations to increase caregiver desire to seek CBT for their youth’s anxiety. Caregiver attendees (N = 180) will be cluster randomized by school to receive one of two different approaches for presentations on CBT for youth anxiety. Both approaches will involve community outreach presentations providing information on recognizing youth anxiety, strategies caregivers can use to decrease youth anxiety, and how to seek CBT for youth anxiety. The researcher-only condition will be co-facilitated by two researchers. In the key opinion leader condition, a caregiver key opinion leader from each local community will be involved in tailoring the content of the presentation to the context of the community, co-facilitating the presentation with a researcher, and endorsing strategies in the presentation that they have found to be helpful. In line with the theory of planned behavior, caregiver attendees will complete measures assessing their knowledge of, attitudes towards, perceived subjective norms about, and intention to seek CBT pre- and post-presentation; they will indicate whether they sought CBT for their youth at 3-month follow-up. Results will be analyzed using a mixed method approach to assess the effectiveness of a key opinion leader to increase caregiver demand for CBT. Discussion This study will be the first to examine the potential of key opinion leaders to increase caregiver demand for CBT. If proven effective, the use of key opinion leaders could serve as a scalable dissemination strategy to increase the reach of evidence-based treatments. Trial registration This trial was registered on clinicaltrials.gov (NCT04929262) on June 18, 2021. At the time of trial registration, pre/post-presentation data had been collected from 17 participants; thus, it was retrospectively registered.

The Effect of Caregiver Key Opinion Leaders on Increasing Caregiver Demand for Evidence-Based Practices to Treat Youth Anxiety: Protocol for A Randomized Control Trial

Background: Research has identified cognitive behavioral therapy with exposures (CBT) as an effective treatment for youth anxiety. However, despite implementation efforts, few anxious youth receive CBT. Direct-to-consumer marketing offers a different approach to address unmet need for effective. Involving a local caregiver key opinion leader to direct-to-consumer initiatives may be an effective strategy to increase caregiver demand for CBT. Research indicates that key opinion leaders improve health promotion campaigns, but key opinion leaders have not been studied in the context of increasing caregiver demand for evidence-based treatments.Method: Project CHAT (Caregivers Hearing about Anxiety Treatments) will test the role of key opinion leader participation in conducting outreach presentations to increase caregiver desire to seek EBPs for their youth’s anxiety. Caregiver attendees (N = 180) will be cluster-randomized by school to receive one of two different approaches for presentations on EBPs for youth anxiety. Both approaches will involve community outreach presentations providing information about (a) youth anxiety, (b) effective treatments for youth anxiety, and (c) seeking CBT for youth anxiety. The researcher-only condition will be co-facilitated by two researchers. In the key opinion leader condition, a caregiver key opinion leader from each local community will be involved in tailoring the content of the presentation to the context of the community, co-facilitating the presentation with a researcher, and endorsing strategies in the presentation that they have found to be helpful. In line with the theory of planned behavior, caregiver attendees will complete measures assessing their knowledge of, attitudes towards, perceived subjective norms about, and intention to seek CBT pre- and post-presentation; they will indicate whether they sought CBT for their youth at a three-month follow-up. Results will be analyzed using a mixed method approach to assess the effectiveness of a key opinion leader to increase caregiver demand for CBT.Discussion: This study will be the first to examine the potential of key opinion leaders to increase caregiver demand for CBT. If proven effective, the use of key opinion leaders could serve as a scalable dissemination strategy to increase the reach of evidence-based treatments. Trial registration: This trial was registered on clinicaltrials.gov (NCT04929262) on June 18, 2021. At the time of trial registration, pre/post presentation data had been collected from 17 participants; thus, it was retrospectively registered.

KOLs

This chapter considers the physicians who advised the pharmaceutical industry in the interest of bringing an effective compound to the attention of the profession. It mentions Roland Kuhn, the Swiss asylum psychiatrist who in 1957 discovered the effectiveness of imipramine in depression and advised about marketing strategies to use to sell the drug. It also highlights the true nature of the testimonials of physicians, which is well known to the industry. The industry’s contempt for them is shown by its vernacular term for sources, which are called “stables.” The chapter focuses on the “stables” of the 1980s that later became Key Opinion Leaders (KOLs). It points out that the sardonic term KOL first appeared in industry correspondence as an insider expression for academics.

Recommendations to promote breast milk feeding and enhance nutritional care for preterm infants in the Asia-Pacific region: highlights from a roundtable discussion of key opinion leaders

Introduction: Preterm infants are vulnerable to nutritional deficiencies, thus optimal nutrition is crucial in promoting growth among these infants. However, socio-cultural complexities and limited resources in the Asia-Pacific demands a judicious approach in implementing nutritional care that is pragmatic to align with current evidence-based recommendations. Methods: A roundtable meeting was held in Jakarta in 2017 for key opinion leaders in neonatology from the AsiaPacific to discuss issues when delivering nutritional care in this region and the unique circumstances encountered. Results: Priority areas discussed include: (i) breast milk feeding, (ii) donor milk bank/sharing, (iii) human milk fortification, and (iv) nutrient-enriched breast milk substitutes. Socio-cultural practices impeding breastfeeding, insufficient maternity leave, the religious issue of milk kinship, and limited availability of specialty nutritional care products were among the most challenging factors. Conclusion: The group proposed recommendations to enhance breastfeeding uptake, accessibility to a complete portfolio of specialty nutritional care products, and encouraging more active collaborations to engage policy makers in addressing these contemporary issues.

Editor's Memo

The COVID-19 pandemic has exposed fundamental disparities in the provision of health care across our nation and exacerbated the differences in health outcomes associated with race, socioeconomic and other demographic factors. A silver lining however is that pandemic precarity has inspired tremendous scientific collaboration among clinicians, researchers, and key opinion leaders. In this line, this year’s Annual Meeting of the American Society of Clinical Oncology (ASCO21) which was kicked off virtually on June 4 through June 8, not only celebrated latest breakthroughs in cancer research, treatment and patient care, but also focused on health equity in cancer care. ASCO21’s fitting theme - Health equity “doing right by the patients for whom we care” reflected addressing complex forces and systems that have created disparities in cancer care, treatment, and research and identifying ways to ensure that all patients have access to and benefit from the latest cancer advances and high-quality cancer care.

Rekomendasi Pedoman Komunikasi Pemasaran Berbasis Pertimbangan Etika Key Opinion Leaders Industri e-Commerce

Dengan semakin bertumbuhnya penetrasi internet di Indonesia, ditambah dengan efek dari COVID-19 di tahun 2020 lalu, industri e-commerce menjadi bertumbuh pesat. Selain itu, pertumbuhan influencer juga menjadi salah satu strategi yang menjadi mulai dikenal dan diadopsi oleh beberapa perusahaan. Penggunaan influencer sebagai strategi pemasaran sering dikenal juga sebagai sebagai influencer marketing, yaitu penggunaan beberapa orang yang memiliki kemampuan untuk meningkatkan pengetahuan konsumen terhadap suatu brand. Sekelompok orang ini yang dikenal sebagai Key Opinion Leaders ini menjadi banyak juga digunakan, salah satunya di industri e-commerce. Melalui penelitian ini, peneliti melakukan penelitian kualitatif dengan cara observasi terhadap salah satu perusahaan e-commerce selama 3.5 bulan secara langsung, melakukan wawancara mendalam terhadap 3 Key Opinion Leaders (KOL) dan 3 karyawan yang bekerja erat dengan para KOL, sehingga dapat memahami isu bisnis yang terjadi, lalu juga dapat menyusun strategi pemasaran dalam bentuk pedoman sebagai solusi isu yang terjadi dan mencegah adanya persoalan-persoalan etika di kemudian hari.

Sunshine on KOL : a retrospective study about financial ties between medical key opinion leaders and pharmaceutical industry in France

Objective To investigate the nature, extent and evolution of financial relationships between key opinion leaders (KOL) or non-KOL physicians and pharmaceutical and device companies in France. Design Retrospective and descriptive study Setting All doctors practicing in France, with a focus on 548 KOL defined as board members of all the professional medical associations having published clinical practice guidelines in 2018 or 2019. These 99 associations were identified by the cross-checking of 3 databases. Main outcome measures The number and the amount of gifts (year by year since 2014), remunerations and agreements (year by year since 2017). Results Physicians had 818m Euros (936m dollars, 741m pounds) of gifts declared from 2014 to 2019. 83% of KOL had such links of interest. The 548 identified KOL represented 0.24% of physicians in France but received 1.5% of the total amount of gifts, i.e. 12.3m euros (14m dollars or 11m pounds / 3,700K euros per capita per year). Physicians had 125m Euros (143m dollars and 114m pounds) of agreements declared from 2017 to 2019. The 548 KOL received 0.72% of the agreements and 2.5% of the value of the agreements, i.e. 3.1m Euros (3.6m dollars, 2.8m pounds) or 1 900 euros per capita per year. Physicians had 156m Euros of remunerations declared from 2017 to 2019. The 548 identified KOL received 4.4% of the total value of remunerations to physicians, i.e. 6.8m Euros or 4 100 Euros per capita per year. Almost every professional medical associations (99%) had in their board at least one KOL with a financial tie. Conclusion Financial relationships between KOL and the industry in France are extensive, KOL have much more financial ties than non-KOL practitioners. The main limit of this study arises from the quality of information provided on the French Transparency in Healthcare database. Pre-registration: osf.io/m8syh

Identification of Key Opinion Leaders in Pharmaceutics Using Network Analysis

The term Key Opinion Leader in marketing is not new. Key Opinion Leaders (KOLs) commonly known as thought leaders who play a crucial role in the life science industry. We through this project intend to implement the concept of identifying key opinion leaders using weighted Social Network Analysis (SNA). We intend to use European PubMed Central dataset for creating a weighted social Network of authors who have healthcare and medicine related publications and apply different centrality measures on it. In order to collect the data, we will be using one of the web scraping methods and predefined libraries like scrapy. After fetching and processing the data we intend to form a network of authors using python’s NetworkX library. This network will then be subjected to various centrality measures which in turn will give prominent opinion leaders as the output.