labisia pumila
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Author(s):  
Nazmun Nahar ◽  
Suhaila Mohamed ◽  
Noordin Mohamed Mustapha ◽  
Lau Seng Fong ◽  
Nur Iliyani Mohd Ishak

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Alif Aiman Zakaria ◽  
Mohd Hezmee Mohd Noor ◽  
Hafandi Ahmad ◽  
Hasliza Abu Hassim ◽  
Mazlina Mazlan ◽  
...  

The Labisia pumila (LP) is a traditional plant that is locally known as Kacip Fatimah, Selusuh Fatimah, or Pokok Ringgang by the Malaysian indigenous people. It is believed to facilitate their childbirth, treating their postchild birth and menstrual irregularities. The water extract of LP has shown to contain bioactive compounds such as flavonoids, ascorbic acid, β-carotene, anthocyanin, and phenolic acid, which contribute extensive antioxidant, anti-inflammatory, antimicrobial, and antifungal. The LP ethanolic extract exhibits significant estrogenic effects on human endomentrial adenocarcinoma cell in estrogen-free basal medium and promoting an increase in secretion of alkaline phosphate. Water based has been used for many generations, and studies had reported that it could displace in binding the antibodies and increase the estradiol production making it similar to esterone and estradiol hormone. LP extract poses a potential and beneficial aspect in medical and cosmeceutical applications. This is mainly due to its phytoestrogen properties of the LP. However, there is a specific functionality in the application of LP extract, due to specific functional group in phytoconstituent of LP. Apart from that, the extraction solvent is important in preparing the LP extract as it poses some significant and mild side effects towards consuming the LP extracts. The current situation of women reproductive disease such as postmenopausal syndrome and polycystic ovary syndrome is increasing. Thus, it is important to find ways in alternative treatment for women reproductive disease that is less costly and low side effects. In conclusion, these studies proven that LP has the potential to be an alternative way in treating female reproductive related diseases such as in postmenopausal and polysystic ovarian syndrome women.


2021 ◽  
Vol 3 (1) ◽  
pp. 139-143
Author(s):  
Nur Nazihah M. ◽  
Farah Fazwa M.A. ◽  
Zunoliza A. ◽  
Anee Suryani S. ◽  
Siti Salwana H.

Labisia pumila, known as kacip fatimah is a traditional herbs widely used for women. The herb was used as a post partum medicine to help contract the birth channel. From previous research, 120 clones of Labisia pumila var. alata was collected from three different locations and 30 clones of the herbs was found having high yielding of total phenolic content (TPC). In this study, one clone from each location was selected for further analyses, which are TA14 from Kuala Berang, TSA13 from Kemaman and DA20 from Gua Musang. Fourier Transform Infrared spectroscopy (FTIR) associated with second derivative infrared spectroscopy was applied to identify the chemical fingerprint of each clone of Labisia pumila. This analytical method is highly rapid and effective for analysis of medicinal herbs. Second derivative IR spectroscopy could enhance the spectral resolution by amplifying tiny differences in the IR spectrum. In this method, the whole chemical property of the sample can be revealed and shown in the IR spectrum. A total of ten absorption peaks were obviously present in the IR spectra which can be used to characterize the species. The IR spectra shows the presence of broader peak at frequencies of range 3266 – 3338 cm-1 which attributable to the alcohol group. This study also attempts to develop HPLC fingerprint of the selected clones. Observation on HPLC spectra shows the presence of one distinct peak at retention time of 12.30, 12.99 and 12.93 min, respectively in each clone. This compound will be characterized and will be used as reference compound in quality assessment in plant breeding


2021 ◽  
Author(s):  
Alif Aiman Zakaria ◽  
Mohd Qayyum Ab Latip ◽  
Tengku Rinalfi Putra Tengku Azizan ◽  
Hafandi Ahmad ◽  
Mazlina Mazlan ◽  
...  

Abstract Background: Labisia pumila (LP) a Malaysian herb thought to have phytoestrogenic effects in rats with PCOS. In this study we investigate the effects of LP aqueous extracts on bone composition, bone biomarkers and metabolic disorder in female rats fed continuously with high fat diet to induce PCOS. Hypothesis: The administration of Labisia pumila treatment in PCOS rats for 90 days will ameliorate the adverse effect of osteoporosis by reducing the inflammatory cytokine and improving the dermal elasticity of PCOS rats. Study design: On the 90th day of the development of PCOS model rats fed with high fat diet and after the vaginal smear analysis indicating a prolonged estrus cycle of more than 2 weeks, all PCOS rats were divided into 4 groups which consisted of control, placebo (water), LP25 (LP 25mg/kg) and LP50 (LP 50 mg/kg) respectively. All PCOS continue to received the formulated high fat diet and control animals continued to received normal chow and water ad libitum. Method: Vehicle and treatments, which were given orally by using stomach gavaging needle size 16 gauge straight and curve retrolingual administration. The rats were sacrificed at the end of the trial phase and organs, tissues and blood samples were harvested for multiple assays and analysis listed below.Results: The level of estradiol was significantly increased in LP25 and LP50 as compared with placebo. The inflammatory cytokine of C-reactive protein and TNF-ɑ were significantly decreased in LP25 and LP50.Conclusion: Treatment of LP extract might reduce the inflammatory cytokine related to the formation of osteoporosis and loss of bone mass, increase the insulin sensitivity and reduce of osteoporosis in PCOS patients. The phytoestrogenic of LP all of the above significant positive results are proven in lowering osteoporosis and metabolic disorder in PCOS rats.


Plants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 717
Author(s):  
Auni Aqilah Ahmad Tarmizi ◽  
Alina Wagiran ◽  
Faezah Mohd Salleh ◽  
Lee Suan Chua ◽  
Farah Izana Abdullah ◽  
...  

Labisia pumila is a precious herb in Southeast Asia that is traditionally used as a health supplement and has been extensively commercialized due to its claimed therapeutic properties in boosting a healthy female reproductive system. Indigenous people used these plants by boiling the leaves; however, in recent years it has been marketed as powdered or capsuled products. Accordingly, accuracy in determination of the authenticity of these modern herbal products has faced great challenges. Lack of authenticity is a public health risk because incorrectly used herbal species can cause adverse effects. Hence, any measures that may aid product authentication would be beneficial. Given the widespread use of Labisia herbal products, the current study focuses on authenticity testing via an integral approach of DNA barcoding and qualitative analysis using HPLC. This study successfully generated DNA reference barcodes (ITS2 and rbcL) for L.pumila var. alata and pumila. The DNA barcode that was generated was then used to identify species of Labisia pumila in herbal medicinal products, while HPLC was utilized to determine their quality. The findings through the synergistic approach (DNA barcode and HPLC) implemented in this study indicate the importance of both methods in providing the strong evidence required for the identification of true species and to examine the authenticity of such herbal medicinal products.


2021 ◽  
Vol 14 (2) ◽  
pp. 142
Author(s):  
Bee Ping Teh ◽  
Norzahirah Ahmad ◽  
Elda Nurafnie Ibnu Rasid ◽  
Nor Azlina Zolkifli ◽  
Umi Rubiah Sastu@Zakaria ◽  
...  

A combined polyherbal formulation containing tongkat ali (Eurycoma longifolia) and kacip fatimah (Labisia pumila) aqueous extracts was evaluated for its safety aspect. A repeated dose 28-day toxicity study using Wistar rats was conducted where the polyherbal formulation was administered at doses 125, 500 and 2000 mg/kg body weight to male and female treatment groups daily via oral gavage, with rats receiving only water as the control group. In-life parameters measured include monitoring of food and water consumption and clinical and functional observations. On day 29, blood was collected for haematological and biochemical analysis. The rats were necropsied and the organs were collected for histopathological examination. This study showed that the combined formulation did not induce any significant toxicity effect at any dose level in terms of morbidity, mortality, behaviour, functional observation, body weight, food and water consumption, whole blood haematology and serum biochemistry. However, there were some microscopic changes in the histopathological examinations of some organs given 2000 mg/kg body weight, which may suggest an early response to the polyherbal formulation. From this study, the no observed adverse effect level is estimated to be more than 500 mg/kg body weight but not exceeding 2000 mg/kg body weight. The observed effects at the highest dose indicate the need for further study of longer dosing duration.


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