bacterial antibiotic resistance
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Author(s):  
Qipeng Cheng ◽  
Zhiwei Zheng ◽  
Lianwei Ye ◽  
Sheng Chen

A multidrug-resistant Vibrio alginolyticus isolate recovered from a shrimp sample with reduced carbapenem susceptibility produced a novel metallo-β-lactamase, VAM-1. That carbapenemase shared 67% to 70% amino acid identity with several VMB family subclass B1 MBLs which were recently reported among some marine bacteria including Vibrio , Glaciecola and Thalassomonas . The bla VAM-1 gene was located in a novel conjugative plasmid, namely pC1579 and multiple copies of bla VAM-1 via an unusual mechanism of gene amplification were detected in pC1579. These findings underline the emergence of marine organisms acting as natural reservoirs for MBL genes and the importance of continuous bacterial antibiotic resistance surveillance.


Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4737
Author(s):  
Ángel Sánchez-González ◽  
Nuno A. G. Bandeira ◽  
Iker Ortiz de Luzuriaga ◽  
Frederico F. Martins ◽  
Sawssen Elleuchi ◽  
...  

This work provides new insights from our team regarding advances in targeting canonical and non-canonical nucleic acid structures. This modality of medical treatment is used as a form of molecular medicine specifically against the growth of cancer cells. Nevertheless, because of increasing concerns about bacterial antibiotic resistance, this medical strategy is also being explored in this field. Up to three strategies for the use of DNA as target have been studied in our research lines during the last few years: (1) the intercalation of phenanthroline derivatives with duplex DNA; (2) the interaction of metal complexes containing phenanthroline with G-quadruplexes; and (3) the activity of Mo polyoxometalates and other Mo-oxo species as artificial phosphoesterases to catalyze the hydrolysis of phosphoester bonds in DNA. We demonstrate some promising computational results concerning the favorable interaction of these small molecules with DNA that could correspond to cytotoxic effects against tumoral cells and microorganisms. Therefore, our results open the door for the pharmaceutical and medical applications of the compounds we propose.


Author(s):  
Zainura Zainon Noor ◽  
Zainab Rabiu ◽  
Mohd. Helmi Mohd. Sani ◽  
Abdul Fatah A. Samad ◽  
Mohd. Farizal Ahmad Kamaroddin ◽  
...  

mSphere ◽  
2021 ◽  
Author(s):  
Jinyong Wu ◽  
Xiaohong Dong ◽  
Lihua Zhang ◽  
Yufei Lin ◽  
Kun Yang

The dissemination of bacterial antibiotic resistance is a serious threat to human health. The development of new antibiotics faces both economic and technological challenges.


2021 ◽  
Vol 12 ◽  
Author(s):  
Zhen Li ◽  
Lishan Zhang ◽  
Qingli Song ◽  
Guibin Wang ◽  
Wenxiao Yang ◽  
...  

Bacterial antibiotic resistance is a serious global problem; the underlying regulatory mechanisms are largely elusive. The earlier reports states that the vital role of transcriptional regulators (TRs) in bacterial antibiotic resistance. Therefore, we have investigated the role of TRs on enoxacin (ENX) resistance in Aeromonas hydrophila in this study. A label-free quantitative proteomics method was utilized to compare the protein profiles of the ahslyA knockout and wild-type A. hydrophila strains under ENX stress. Bioinformatics analysis showed that the deletion of ahslyA triggers the up-regulated expression of some vital antibiotic resistance proteins in A. hydrophila upon ENX stress and thereby reduce the pressure by preventing the activation of SOS repair system. Moreover, ahslyA directly or indirectly induced at least 11 TRs, which indicates a complicated regulatory network under ENX stress. We also deleted six selected genes in A. hydrophila that altered in proteomics data in order to evaluate their roles in ENX stress. Our results showed that genes such as AHA_0655, narQ, AHA_3721, AHA_2114, and AHA_1239 are regulated by ahslyA and may be involved in ENX resistance. Overall, our data demonstrated the important role of ahslyA in ENX resistance and provided novel insights into the effects of transcriptional regulation on antibiotic resistance in bacteria.


2021 ◽  
Author(s):  
Huiying Fang ◽  
Guandi Zeng ◽  
Jing Zhao ◽  
Tingkai Zheng ◽  
Lina Xu ◽  
...  

AbstractBacterial antibiotic resistance sets a great challenge to human health. It seems that the bacteria can spontaneously evolve resistance against any antibiotic within short time without the horizontal transfer of heterologous genes and before accumulating drug-resistant mutations. We have shown that the tRNA-mediated translational regulation counteracts the reactive oxygen species in bacteria. In this study, we demonstrated that isolated and subcultured Escherichia coli elevated its tRNAs under antibiotic stress to rapidly provide antibiotic resistance, especially at the early stage, before upregulating the efflux pump and evolving resistance mutations. The DNA recombination system repaired the antibiotic-induced DNA breakage in the genome, causing numerous structural variations. These structural variations are overrepresented near the tRNA genes, which indicated the cause of tRNA up-regulation. The strains knocking out the recombination system could not up-regulate tRNAs, and coincidently, they could hardly evolve antibiotic resistance in multiple antibiotics, respectively. With these results, we proposed a multi-stage model of bacterial antibiotic resistance in an isolated scenario: the early stage (recombination – tRNA up-regulation – translational regulation); the medium stage (up-regulation of efflux pump); the late stage (resistance mutations). These results also indicated that the bacterial DNA recombination system and tRNA could be targeted to retard the bacterial spontaneous drug resistance.


2020 ◽  
Vol 18 (6) ◽  
pp. 855-857
Author(s):  
Gary Toranzos ◽  
Maronel Steyn ◽  
Tasha Santiago-Rodriguez ◽  
Daisuke Sano

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