Abstract
An in-silico study, using the GALAS algorithm available in ACD/Percepta, was performed to calculate the pKa(s) of the various oximes with potential application as peptide coupling additives. Among the known oximes and predicted structures, OxymaPure is superior based on the pKa values calculated, confirming the results described in the literature and validating this algorithm for further uses in that field. Among the non-described oximes, based on pKa calculation, ethyl 2-(hydroxyimino)-2-nitroacetate seems to be a potential candidate to be used as an additive during peptide coupling.
3D-bioprinted peptide coupling patches for wound healing