Estate landscapes in the Netherlands

In the past, country house research was mainly concerned with individual houses and gardens. Yet, as early as the seventeenth and eighteenth centuries, so many country houses were being built around the major cities that they came to define the landscape. Genuine estate landscapes took shape along several rivers (Amstel, Vecht), along the inner edge of coastal dunes, and on newly reclaimed land. In the middle of the seventeenth century, the rivers were augmented with a network of barge canals and soon they too were lined by a belt of country houses. The greatest density of country houses was to be found around Amsterdam, but other big cities in the provinces of Holland and Zeeland had their fair share as well. Access was mostly by water, but in some areas, especially in Zeeland, country roads performed this role. The majority of country houses were built on or next to a farm, which generally continued to exist and, in many cases, survived the country house. In a few areas, the evolving density of country houses has been traced in a detailed chronological record. In most cases it reveals progressive growth towards a high point in the first half of the eighteenth century, after which a gradual decline sets in. However, in a number of areas growth was much more rapid, in particular along the River Vecht. Sustained growth was followed by decline. In the final decade of the eighteenth century and the first decade of the nineteenth, large numbers of country houses were demolished and in many instances the land reverted to agriculture production. It appears that the decline set in earlier in Zeeland than in Holland, but regional differences in decline are not yet entirely clear. The second quarter of the nineteenth century saw the construction of a new generation of country houses, especially in the undulating sandy areas of the Utrechtse Heuvelrug and the southern part of the Veluwezoom, where railway lines provided access. The owners of this new crop of country houses laid out their gardens in the English landscape style. They also bought up vast, neighbouring heathlands from local councils or farmers and planted them with trees. As a result, these country houses are quite different in character from those of the earlier period. In the past the concentrations of country houses dominated the landscape and even today, wherever they have survived to a substantial degree they continue to represent an important landscape quality. As such, protection and management should not be confined to individual country houses but should extend to groups of country houses and their interrelationships (in the form of visual axes, for example). In recent years, a number of provinces have already set a good example by formulating policies for country house biotopes and linear estate landscapes.

Gaming Slang Terms in Russian Online Media: A Case Study of News Articles

The goal of this study is to identify gaming slang terms in the news articles of highly rated Russian media. Three online newspapers of various types were used as an empirical material: Kommersant (the first private business newspaper in Russia), RBC (a socio-political analytical newspaper) and Rossiyskaya Gazeta (agency of the Russian Federation government). With help of the content analysis of the media texts, all cases of using the slang gaming terms such as achievement, noob, easter eggs etc. have been discovered and described. The results of the study show that over the past five years the popularity of the gaming terms usage in the media has been growing; this increase can be described as a linear progressive growth: gaming slang is becoming an integral part of the Runet online resources and is gradually entering common vocabulary. It can be assumed that with the increase in the number of media managers from the generation of digital natives and their transition to the category of decision makers, the growth of gaming slang terms in online media will become exponential.

Estudio de las temáticas y contenidos de las tesis doctorales realizadas en España sobre Biomecánica Deportiva (Study of the themes and contents of the doctoral theses carried out in Spain on Sports Biomechanics)

El objeto del estudio es conocer y valorar la evolución de las temáticas y contenidos de las tesis doctorales que se han leído en España sobre Biomecánica Deportiva durante el periodo comprendido entre los años 1980 y 2019. La muestra está compuesta de 233 tesis después de un proceso de selección con el uso de criterios de inclusión/exclusión y términos de búsqueda específicos. Los resultados demuestran que existe un crecimiento progresivo en la producción de tesis doctorales a lo largo del tiempo con incrementos progresivos, especialmente en el tercer y cuarto periodo. Los campos temáticos con mayor número de tesis leídas son los de Biomecánica de Apoyo y de Biomecánica Aplicada. El campo de Biomecánica Básica resulta residual, con tres tesis leídas a lo largo del periodo investigado. En la Biomecánica de Apoyo, el subcampo más representado y con un crecimiento constante, es el del Área Médica, con 73 tesis leídas que representa el 68,2% del total del campo temático. En la Biomecánica Aplicada, los subcampos con más tesis leídas son los de Análisis de la Técnica Deportiva y de Análisis del Movimiento con 35 y 32 tesis leídas, respectivamente, sin que se observe un crecimiento constante a lo largo del tiempo. El campo de Biomecánica-Tecnologías es el tercero con un 10,7% de las tesis leídas. El término más utilizado en los títulos de las tesis es el de la “marcha” que se convierte en un tema transversal que ha sido abordado desde diferentes perspectivas científicas. Abstract: The purpose of the study is to know and assess the evolution of the themes and contents of the doctoral theses that have been read in Spain on Sports Biomechanics during the period between 1980 and 2019. The sample is made up of 233 theses after a selection process with the use of inclusion / exclusion criteria and specific search terms. The results show that there is a progressive growth in the production of doctoral theses over time with progressive increases, especially in the third and fourth periods. The thematic fields with the highest number of theses read are Support Biomechanics and Applied Biomechanics. The Basic Biomechanics field is a residual field with 3 theses read over time. In Support Biomechanics, the most represented subfield with constant growth is the Medical Area with 73 theses read, representing 68.2% of the total thematic field. In Applied Biomechanics, the subfields with the most theses read are the Analysis of Sports Technique and Analysis of Movement with 35 and 32 theses read, with no constant growth observed over time. The Biomechanics-Technologies field is the third with 10.7% of the theses read. The term most used in the thesis titles is "walking", which becomes a cross-cutting theme that has been approached from different scientific perspectives.

Prospective Study of Communication and Information Technologies for the Deaf

This article presents a prospective study of Information Technologies and Communication for Deaf people. Aims to carry out a technological investigation of patents filed in Questel Orbit, to identify the Accessible Information and Communication Technologies developed for Deaf people. The methodological path in this research is a systematic review, exploratory, and prospective study of technologies. So, we identified ninety-two documents filed in the Orbit patent database. This prospective study showed a progressive growth of papers in the last five years, but discreet regarding developed Deaf technologies' registration. It also highlights that China has the highest number of these technologies, while Brazil has only one technology developed.

Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling

The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is widely known for its role in degrading abnormal protein substrates and maintaining physiological body functions via ubiquitinating enzymes (E1, E2, E3) and the proteasome. Therefore, aberrant expression in these enzymes results in an altered biological process, including transduction signaling for cell death and survival, resulting in cancer. In this review, an overview of profuse enzymes involved as a pro-oncogenic or progressive growth factor in tumors with their downstream signaling pathways has been discussed. A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elsevier) databases was carried out to understand the nature of the extensive work done on modulation of ubiquitin-proteasome pathways in oncogenic signaling. Various in vitro, in vivo studies demonstrating the involvement of ubiquitin-proteasome systems in varied types of cancers and the downstream signaling pathways involved are also discussed in the current review. Several inhibitors of E1, E2, E3, deubiquitinase enzymes and proteasome have been applied for treating cancer. Some of these drugs have exhibited successful outcomes in in vivo studies on different cancer types, so clinical trials are going on for these inhibitors. This review mainly focuses on certain ubiquitin-proteasome enzymes involved in developing cancers and certain enzymes that can be targeted to treat cancer.

Arteriovenous Malformation in the Auricle in a 59-Year-Old Woman

Arteriovenous malformation (AVM) is a vascular lesion with a direct communication between an artery and a vein without a capillary system. AVM primarily occurs in the intracranial area, but can also occur in the extracranial area. If there is a tender mass with pulsation or recurrent bleeding in the auricle, AVM should be considered even though it rarely occurs in the auricle. AVM in the ear should be managed carefully because the skin is thin in the ear, the cartilage could be involved, and progressive growth or inappropriate management could cause bleeding, infection, and cosmetic problems such as deformity. I present a case of a 59-year-old woman with AVM in the auricle.

Establishing genetic relationships between the Takidani pluton and two large silicic eruptions in the Northern Japan Alps

The Takidani pluton (1.1-1.6 Ma) represents a shallow magmatic reservoir at the base of an exhumed caldera floor. The deposits of two large caldera-forming eruptions including the Nyukawa Pyroclastic Flow Deposit (1.76 Ma; crystal-rich dacite) and the Chayano Tuff and Ebisutoge Pyroclastic Deposits (1.75 Ma; a sequence of crystal-poor rhyolite) are distributed concentrically around the pluton. We use major and trace element chemistry of whole-rock, glass and minerals to show (1) that the crystal-rich dacite (>400 km3 DRE; dense rock equivalent) is the erupted portion of a shallow mush zone constituting the Takidani pluton and (2) that the crystal-poor rhyolite (>100 km3 DRE) was extracted from a deeper part of this vertically extended magmatic plumbing system. Whole-rock geochemistry indicates that the Nyukawa and Takidani compositions were produced dominantly through crystal fractionation of amphibole, pyroxene and plagioclase in the mid-to-lower crust and subsequently emplaced in the upper crust prior to eruption and solidification, respectively. The crystal-poor Chayano-Ebisutoge rhyolite (>100 km3 DRE) is compositionally distinct from the Nyukawa and Takidani magmas and its generation is associated with a substantial contribution of crustal melts. Yet, plagioclase and orthopyroxene textures and chemistry provide strong evidence that the ascending rhyolite percolated through the upper Takidani-Nyukawa mush zone prior to eruption. Overgrowth of “rhyolitic plagioclase” on “xenocrystic dacitic plagioclase” typical of the Takidani-Nyukawa magmas indicates that the extraction and accumulation of the rhyolitic melts could have occurred in less than 10 kyr (i.e. time between eruptions) prior to eruption providing maximum timescales for pre-eruption storage. Overall, our findings show a progressive growth and thermal maturation of a vertically extended magmatic plumbing system over hundreds of thousands of years and imply that large volcanic eruptions can occur in relatively short succession without dramatic changes in the plumbing system, thus, complicating the identification of signs of an impending large eruption.

Transforming the Media and Entertainment Industry

Technology is the mast that keeps the flag of the entertainment industry flying high. As technology evolves and the mode and quality of entertainment changes vigorously, India represents one of the Top 5 Entertainment and Media markets across the world. The growing usage of 3G, 4G and portable devices, rising advertising revenues, growing consumer demand has resulted in the growth of the Indian media and entertainment industry at a CAGR of 10.9 percent from FY 17-18. Constant support from TRAI (Telecom Regulatory authority of India) and the Govt. of India has pushed the Indian Media and Entertainment(M&E) Industry on a progressive growth path. This manuscript traces the evolution of the M&E landscape and discusses specific cases from the M&E industry where social media has been instrumental in hugely impacting the consumption of the M&E content.

Labor productivity and socio-economic ways to increase it

The growth of labor productivity is a priority direction in the development of any production. It contributes to the ability to produce additional volume of products or to bring the existing one to a new level of quality. At the present stage of the world economy, increasing labor productivity is the main source of the company’s progressive growth.