A Computerized Simulation of the Occlusal Surface in Equine Cheek Teeth: A Simplified Model

Equine mastication, as well as dental wear patterns, is highly important for the development of treatments in equine dentistry. During the last decades, the stress and strain distributions of equine teeth have been successfully simulated using finite element analysis. Yet, to date, there is no simulation available for dental tooth wear in equines. In this study, we developed a simplified two-dimensional computer simulation of dental wear. It provides a first tentative explanation for the development of the marked physiological inclination of the occlusal surface and for pathological conditions such as sharp enamel points in equine cheek teeth. The mechanical properties of the dental structures as well as the movement of the mandible during the equine chewing cycle were simulated according to previously published data. The simulation setup was optimized in preliminary test runs. Further simulations were conducted varying the lateral excursion of the mandible and the presence or absence of incisor contact during the chewing cycle. The results of simulations showed clear analogies to tooth wear patterns in living equids, including the formation of wear abnormalities. Our analysis indicates that small variations in the pattern of movement during the masticatory cycle, as well as incisor contacts, are leading to marked changes in the occlusal tooth wear patterns. This opens new research avenues to better understand the development of dental wear abnormalities in equines and might have serious implications on captive animal health, welfare, and longevity.

Operationalising the Deprivation of Liberty Safeguards (DoLS) in support of brain injury survivors – views from practice

Purpose Deprivation of Liberty Safeguards (DoLS), as part of the Mental Capacity Act 2005 (DoLS, 2007), was established to provide a legal framework for decision-making in respect of adults who lack capacity to make decisions in relation to their care and residence in England and Wales. The purpose of this study was to explore the DoLS decision-making process from the perspectives of health and social care practitioners when working with individuals with an acquired brain injury (ABI). Design/methodology/approach A total of 12 health and social care practitioners were interviewed in 2019–2020 about their experiences of using and making or supporting decisions in the DoLS framework with ABI survivors. Data were analysed, and a tentative explanation of variations in DoLS decision-making was developed. Findings Three distinct approaches emerged capturing different decision-making styles (risk-averse, risk-balancing and risk-simplifying) which appeared to influence the outcome of DoLS assessments. A range of mediating factors seemed to account for the variability in these styles. The wider contextual challenges that impact upon practitioners’ overall experiences and use of DoLS processes in their ABI practice were noted. Research limitations/implications The findings highlight a need for changes in practice and policy in relation to how DoLS or similar processes are used in decision-making practice with ABI survivors and may be relevant to the implementation of the Liberty Protection Safeguards that are replacing the DoLS system. Originality/value To the best of the authors’ knowledge, this is the first study to explore accounts of DoLS decision-making practices in ABI service.

Photosynthetic Light-Harvesting (Antenna) Complexes—Structures and Functions

Chlorophylls and bacteriochlorophylls, together with carotenoids, serve, noncovalently bound to specific apoproteins, as principal light-harvesting and energy-transforming pigments in photosynthetic organisms. In recent years, enormous progress has been achieved in the elucidation of structures and functions of light-harvesting (antenna) complexes, photosynthetic reaction centers and even entire photosystems. It is becoming increasingly clear that light-harvesting complexes not only serve to enlarge the absorption cross sections of the respective reaction centers but are vitally important in short- and long-term adaptation of the photosynthetic apparatus and regulation of the energy-transforming processes in response to external and internal conditions. Thus, the wide variety of structural diversity in photosynthetic antenna “designs” becomes conceivable. It is, however, common for LHCs to form trimeric (or multiples thereof) structures. We propose a simple, tentative explanation of the trimer issue, based on the 2D world created by photosynthetic membrane systems.

Keynes's trading on Wall Street: did he follow the same behaviour when investing for himself and for King's?

In the last few years Keynes's investment activity, both as an individual trader and as a manager of institutions’ portfolios, has attracted attention in the specialised literature. Recently his investments on Wall Street, in particular – both on his own account (Cristiano, Marcuzzo and Sanfilippo 2018) and on behalf of King's College, Cambridge (Chambers and Kabiri 2016) – have been analysed, and the evident connection with his theoretical analysis of the functioning of the financial markets contained in chapter 12 of The General Theory has been duly stressed. This article aims to contribute to a more comprehensive understanding of Keynes's trading behaviour on Wall Street by providing a detailed comparison of his investment choices when he traded for himself and for King's. There are similarities, as might be expected, but also significant differences, well worth investigating. As far as the differences are concerned, one of the most striking is to be seen, for instance, in his attitude when, after a period of bull market in 1936, he had to face the spring 1937 burst of the speculative bubble and subsequent recession. Analysis of his behaviour in this specific case reveals that the event took him by surprise but his reaction differed with regard to his personal investments and the King's investments. The prevalence of a ‘buy and hold’ strategy, which, according to Chambers and Kabiri's reconstruction (2016), marked Keynes's behaviour in general (and also in this particular case) when he invested on behalf of King's, was not always his typical choice when the investments were undertaken on his own account. A tentative explanation of this result, which is also grounded on some different features characterising the two portfolios and not sufficiently investigated in previous studies, is at last provided in the article.

A New Interpretation of the Noble Lie

“Could we contrive one noble lie?” implies there is one noble lie (Republic 414b). The Autochthony Claim (asserting the Best City’s citizens are equally brothers) and the Hierarchical Claim (asserting brother justifiably rules over brother) follow. The article argues the former is the “one” noble lie. It argues the claims are both normative and descriptive propositions; both descriptively true about worldly polities in Plato’s day and historically. While the Hierarchical Claim is normatively true of the Best City, the Autochthony Claim is normatively false. The article offers a tentative explanation why jointly they comprise a foundational myth of political life.

The Fifth Evaluation Wave

With the shift towards new public governance, professionals' and citizens' experiences and knowledge are placed at the heart of public service design, implementation, and evaluation. There are thus beginning indications that the dominant evaluation and governance logic, including the notion that welfare services should be evidence-based and that the quality of public services is best secured using key performance indicators, are in the process of being challenged. Four waves of evaluation have diffused between 1965 and 2010, and a great deal suggests that new public governance, with co-production as the dominant organizational recipe, is carrying a new, fifth evaluation wave with it. The aim of this chapter is to provide a sober but tentative explanation of the content of this fifth evaluation wave. The description of the fifth wave evaluation is structured in respect to “informed evaluation,” which covers reflections on the evaluation domain, knowledge, values, and usage.

The Logic behind the Internal Governance of Sweden’s Largest Agricultural Cooperatives

This study comprises a qualitative analysis of the governance structures within the two largest agricultural cooperatives in Sweden, both of which have large and heterogeneous memberships, as well as sizeable and complex business operations. Interviews were conducted with district council members and representatives from the boards of directors. The data from both case cooperatives indicate a genuinely traditional democratic member governance structure. There is a great deal of social capital in the governance system. A tentative explanation of the member involvement is that the cooperatives’ equity capital is owned by the individual members, and the members are free to sell and buy their shares at a market rate. The members are satisfied with the return on the capital they have invested in the cooperatives. They receive bonus shares and dividends above what most members would get in other investments. A conclusion is that very large cooperatives may succeed well with a member-democratic governance system of the traditional cooperative type, which in this case is probably due to the members’ satisfaction with the individualized ownership of the cooperatives.

The structure and stability of extended, inclined circumplanetary disc or ring systems

ABSTRACT Large dips in the brightness for a number of stars have been observed, for which the tentative explanation is occultation of the star by a transiting circumplanetary disc or ring system. In order for the circumplanetary disc/rings to block the host star’s light, the disc must be tilted out of the planet’s orbital plane, which poses stability problems due to the radial extent of the disc required to explain the brightness dip durations. This work uses N-body integrations to study the structure and stability of circumplanetary disc/ring systems tilted out of the planet’s orbital plane by the spinning planet’s mass quadrupole. Simulating the disc as a collection of test particles with orbits initialized near the Laplace surface (equilibrium between tidal force from host star and force from planet’s mass quadrupole), we find that many extended, inclined circumplanetary discs remain stable over the duration of the integrations ($\sim 3\!-\!16 \, {\rm Myr}$). Two dynamical resonances/instabilities excite the particle eccentricities and inclinations: the Lidov-Kozai effect which occurs in the disc’s outer regions, and ivection resonance which occurs in the disc’s inner regions. Our work places constraints on the maximum radial extent of inclined circumplanetary disc/ring systems, and shows that gaps present in circumplanetary discs do not necessarily imply the presence of exomoons.

The Macroeconomic Models of the Austrian School: A History and Comparative Analysis

This paper offers a synthetic and comparative assessment of the most basic Austrian macroeconomic models, i.e. the models that analyze the static forces determining the equilibrium interest rate and structure of production (monetary disequilibria and business cycles are not part of this investigation). The three models presented here are those of Böhm-Bawerk ([1889] 1959), Hayek (1936, 1941), and Garrison (2001). This review shows that these models are largely inconsistent with each other, but also that at a more general level they share several important charac-teristics. Finally, a tentative explanation is offered as to why there is no cumulative tradition in the Austrian School in this kind of basic macroeconomic theorizing.

MRS Shows Regionally Increased Glutamate Levels among Patients with Exhaustion Syndrome Due to Occupational Stress

Despite the rapid increase of reports of exhaustion syndrome (ES) due to daily occupational stress, the mechanisms underlying ES are unknown. We used voxel-based 1H-MR spectroscopy to examine the potential role of glutamate in this condition. The levels of glutamate were found to be elevated among ES patients (n = 30, 16 females) compared with controls (n = 31, 15 females). Notably, this increase was detected only in the anterior cingulate and mesial prefrontal cortex (ACC/mPFC), and the glutamate levels were linearly correlated with the degree of perceived stress. Furthermore, there was a sex by group interaction, as the glutamate elevation was present only in female patients. Female but not male ES patients also showed an increase in N-acetyl aspartate (NAA) levels in the amygdala. No group differences were detected in glutamine concentration (also measured). These data show the key role of glutamate in stress-related neuronal signaling and the specific roles of the amygdala and ACC/mPFC. The data extend previous reports about the neurochemical basis of stress and identify a potential neural marker and mediator of ES due to occupational stress. The observation of specific sex differences provides a tentative explanation to the well-known female predominance in stress-related psychopathology.