zein protein
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2021 ◽  
Author(s):  
Yang Feng ◽  
Yafei Ma ◽  
Fan Feng ◽  
Xinze Chen ◽  
Weiwei Qi ◽  
...  

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1407
Author(s):  
Courtney van Ballegooie ◽  
Alice Man ◽  
Alessia Pallaoro ◽  
Marcel Bally ◽  
Byron D. Gates ◽  
...  

Drug-delivery vehicles have been used extensively to modulate the biodistribution of drugs for the purpose of maximizing their therapeutic effects while minimizing systemic toxicity. The release characteristics of the vehicle must be balanced with its encapsulation properties to achieve optimal delivery of the drug. An alternative approach is to design a delivery vehicle that preferentially releases its contents under specific endogenous (e.g., tissue pH) or exogenous (e.g., applied temperature) stimuli. In the present manuscript, we report on a novel delivery system with potential for triggered release using external beam radiation. Our group evaluated Zein protein as the basis for the delivery vehicle and used radiation as the exogenous stimulus. Proteins are known to react with free radicals, produced during irradiation in aqueous suspensions, leading to aggregation, fragmentation, amino acid modification, and proteolytic susceptibility. Additionally, we incorporated gold particles into the Zein protein matrix to create hybrid Zein–gold nanoparticles (ZAuNPs). Zein-only nanoparticles (ZNPs) and ZAuNPs were subsequently exposed to kVp radiation (single dose ranging from 2 to 80 Gy; fractionated doses of 2 Gy delivered 10 times) and characterized before and after irradiation. Our data indicated that the presence of gold particles within Zein particles was correlated with significantly higher levels of alterations to the protein, and was associated with higher rates of release of the encapsulated drug compound, Irinotecan. The aggregate results demonstrated a proof-of-principle that radiation can be used with gold nanoparticles to modulate the release rates of protein-based drug-delivery vehicles, such as ZNPs.


2021 ◽  
Vol 22 (7) ◽  
pp. 3795
Author(s):  
Elisa Poyatos-Racionero ◽  
Gemma Guarí-Borràs ◽  
María Ruiz-Rico ◽  
Ángela Morellá-Aucejo ◽  
Elena Aznar ◽  
...  

The development of new food preservatives is essential to prevent foodborne outbreaks or food spoilage due to microbial growth, enzymatic activity or oxidation. Furthermore, new compounds that substitute the commonly used synthetic food preservatives are needed to stifle the rising problem of microbial resistance. In this scenario, we report herein, as far as we know, for the first time the use of the zein protein as a gating moiety and its application for the controlled release of essential oil components (EOCs). The design of microdevices consist of mesoporous silica particles loaded with essential oils components (thymol, carvacrol and cinnamaldehyde) and functionalized with the zein (prolamin) protein found in corn as a molecular gate. The zein protein grafted on the synthesized microdevices is degraded by the proteolytic action of bacterial enzymatic secretions with the consequent release of the loaded essential oil components efficiently inhibiting bacterial growth. The results allow us to conclude that the new microdevice presented here loaded with the essential oil component cinnamaldehyde improved the antimicrobial properties of the free compound by decreasing volatility and increasing local concentration.


2021 ◽  
Author(s):  
Yongkang Xi ◽  
Bo Liu ◽  
Shuxin Wang ◽  
Xiaonan Huang ◽  
Hang Jiang ◽  
...  

A robust chemo- and biocatalytic cascade PIC with a recovery catalyst and a separation product was developed. The results groundbreakingly highlighted the preliminary applications of artificial enzymes and bio-enzymes in a one-pot cascade PIC.


2021 ◽  
Vol 118 ◽  
pp. 111419
Author(s):  
Kelsey DeFrates ◽  
Theodore Markiewicz ◽  
Ye Xue ◽  
Kayla Callaway ◽  
Christopher Gough ◽  
...  
Keyword(s):  
Air Jet ◽  

2020 ◽  
Vol 11 (3) ◽  
pp. 10614-10619

The aim of the present study is to extract natural cellulose and zein protein from Egyptian corn silk using two different protocols being; filtration (NaOH/H2SO4) and Solubility (NaOH/Urea). The extracted cellulose and zein via the two protocols are characterized using XRD, FTIR, and FESEM with EDAX. The biological activity of the extracted zein was assessed. Results proved the successful extraction of cellulose and zein via the two applied protocols. However, significant structural variations had recorded for the extracted cellulose and silk. The solubility protocol produced more crystalline cellulose when compared with the filtration one. The extracted zein via both protocols presents promising antioxidant activity.


2020 ◽  
Vol 8 (2) ◽  
pp. S1-S19
Author(s):  
Hamid Souzandeh ◽  
Anil N. Netravali

The interfacial shear strength (IFSS) between natural sisal fiber and zein protein resin was explored using the microbond test. Commercially available zein protein was processed into resins and their IFSS with sisal fiber was measured. Effects of sorbitol plasticizer content and microfibrillated cellulose (MFC) reinforcement loading on the IFSS with the resin were studied. Scanning electron microscopy (SEM) was used to characterize the fracture surfaces before and after the microbond test. Energy dispersive X-ray spectroscopy (EDX) was utilized to map the residual resin on the sisal fiber surface after the microbond test. The results showed that sisal fiber/ zein IFSS decreased with sorbitol content. At 20 wt% sorbitol content 53% decrease in IFSS was observed. IFSS increased with MFC loading from 1.32 MPa (control) to 2.40 MPa for resin containing 15 wt% MFC. Physical entanglements between sisal fibers and MFC are believed to be responsible for this enhancement in the IFSS.


2020 ◽  
Vol 5 (1) ◽  
pp. 11-16
Author(s):  
Chen Guo ◽  
Xiujie Liu ◽  
Li Chen ◽  
Yupeng Cai ◽  
Weiwei Yao ◽  
...  

2020 ◽  
Vol 118 (3) ◽  
pp. 45a
Author(s):  
Mohammad Madani ◽  
Anna Tarakanova

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