The Patterns of Morphological Change During Intracerebral Hemorrhage Expansion: A Multicenter Retrospective Cohort Study

Objectives: Hemorrhage expansion (HE) is a common and serious condition in patients with intracerebral hemorrhage (ICH). In contrast to the volume changes, little is known about the morphological changes that occur during HE. We developed a novel method to explore the patterns of morphological change and investigate the clinical significance of this change in ICH patients.Methods: The morphological changes in the hematomas of ICH patients with available paired non-contrast CT data were described in quantitative terms, including the diameters of each hematoma in three dimensions, the longitudinal axis type, the surface regularity (SR) index, the length and direction changes of the diameters, and the distance and direction of movement of the center of the hematoma. The patterns were explored by descriptive analysis and difference analysis in subgroups. We also established a prognostic nomogram model for poor outcomes in ICH patients using both morphological changes and clinical parameters.Results: A total of 1,094 eligible patients from four medical centers met the inclusion criteria. In 266 (24.3%) cases, the hematomas enlarged; the median absolute increase in volume was 14.0 [interquartile range (IQR), 17.9] mL. The initial hematomas tended to have a more irregular shape, reflected by a larger surface regularity index, than the developed hematomas. In subtentorial and deep supratentorial hematomas, the center moved in the direction of gravity. The distance of center movement and the length changes of the diameters were small, with median values of less than 4 mm. The most common longitudinal axis type was anterior–posterior (64.7%), and the axis type did not change between initial and repeat imaging in most patients (95.2%). A prognostic nomogram model including lateral expansion, a parameter of morphological change, showed good performance in predicting poor clinical outcomes in ICH patients.Conclusions: The present study provides a morphological perspective on HE using a novel automatic approach. We identified certain patterns of morphological change in HE, and we believe that some morphological change parameters could help physicians predict the prognosis of ICH patients.

Molecular Genetic Understanding of Photoperiodic Regulation of Flowering Time in Arabidopsis and Soybean

The developmental switch from a vegetative phase to reproduction (flowering) is essential for reproduction success in flowering plants, and the timing of the floral transition is regulated by various environmental factors, among which seasonal day-length changes play a critical role to induce flowering at a season favorable for seed production. The photoperiod pathways are well known to regulate flowering time in diverse plants. Here, we summarize recent progresses on molecular mechanisms underlying the photoperiod control of flowering in the long-day plant Arabidopsis as well as the short-day plant soybean; furthermore, the conservation and diversification of photoperiodic regulation of flowering in these two species are discussed.

Modelling Glacier Evolution in Bhutanese Himalaya during the Little Ice Age

Mountain glaciers provide us a window into past climate change and landscape evolution, but the pattern of glacier evolution at centennial or suborbital timescale remains elusive, especially in monsoonal Himalayas. We simulated the glacier evolution in Bhutanese Himalaya, a typical monsoon influenced region, during the Little Ice Age (LIA), using the Open Global Glacier Model and six paleo-climate datasets. Compared with the mapped glacial landforms, the model can well capture the glacier length changes, especially for the experiment driving by the GISS climate dataset, but overestimates the changes in glacier area. Simulation results reveal four glacial substages at 1270s–1400s, 1470s–1520s, 1700s–1710s, and 1820s–1900s in the study area. From further analysis, a negative correlation between the number of the substages and glacier length was found, which suggests that the number and occurrence of glacial substages are regulated by the heterogeneous responses of glaciers to climate change. In addition, the changes in summer temperature dominated the glacier evolution in this region during the LIA.

The Mitochondrial Genome of a Freshwater Pelagic Amphipod Macrohectopus branickii Is among the Longest in Metazoa

There are more than 350 species of amphipods (Crustacea) in Lake Baikal, which have emerged predominantly through the course of endemic radiation. This group represents a remarkable model for studying various aspects of evolution, one of which is the evolution of mitochondrial (mt) genome architectures. We sequenced and assembled the mt genome of a pelagic Baikalian amphipod species Macrohectopus branickii. The mt genome is revealed to have an extraordinary length (42,256 bp), deviating significantly from the genomes of other amphipod species and the majority of animals. The mt genome of M. branickii has a unique gene order within amphipods, duplications of the four tRNA genes and Cox2, and a long non-coding region, that makes up about two thirds of the genome’s size. The extension of the mt genome was most likely caused by multiple duplications and inversions of regions harboring ribosomal RNA genes. In this study, we analyzed the patterns of mt genome length changes in amphipods and other animal phyla. Through a statistical analysis, we demonstrated that the variability in the mt genome length may be a characteristic of certain phyla and is primarily conferred by expansions of non-coding regions.

Taxonomical clarification of Tetrix gibberosa (Wang & Zheng), a high-backed pygmy grasshopper species from eastern PR China (Orthoptera: Tetrigidae)

Tetrix gibberosa (Wang & Zheng) is a high-backed pygmy grasshopper species from eastern PR China. Due to its reduced hind wings and pleomorphism (length changes of hind wings and the hind pronotal process, which is generally called macropterous and brachypterous morphs), the species have been described into different species which involve several taxonomically confused genera. This study clarifies its taxonomy and distribution and provides ecological information for the species. At the same time, we comment the relationships of related genera in the subfamily Tetriginae, including Tetrix Latreille, Exothotettix Zheng & Jiang, Alulatettix Liang, Aalatettix Zheng & Mao, Formosatettix Tinkham, and Formosatettixoides Zheng. Additionally, we report for the first time that nematodes can parasitize pygmy grasshoppers. New synonyms are proposed: Tetrix gibberosa (Wang & Zheng, 1993) = Alulatettix bulbosus Zheng & Zhong, 2001, syn. nov., = Exothotettix jiangxiensis Liang & Jia, 2008, syn. nov., = Tetrix glochinota Zhao, Niu & Zheng, 2010, syn. nov., = Alulatettix nigromarginalis Zhang, Deng & Zha, 2014, syn. nov., = Alulatettix flavotibialis Zhang, Deng & Zha, 2014, syn. nov..

Electro-energetics of Biventricular, Septal and Conduction System Pacing

Abnormal electrical activation of the ventricles creates abnormalities in cardiac mechanics. Local contraction patterns, as reflected by strain, are not only out of phase, but also show opposing length changes in early and late activated regions. Consequently, the efficiency of cardiac pump function (the amount of stroke work generated by a unit of oxygen consumed), is approximately 30% lower in dyssynchronous than in synchronous hearts. Maintaining good cardiac efficiency appears important for long-term outcomes. Biventricular, left ventricular septal, His bundle and left bundle branch pacing may minimise the amount of pacing-induced dyssynchrony and efficiency loss when compared to conventional right ventricular pacing. An extensive animal study indicates maintenance of mechanical synchrony and efficiency during left ventricular septal pacing and data from a few clinical studies support the idea that this is also the case for left bundle branch pacing and His bundle pacing. This review discusses electro-mechanics and mechano-energetics under the various paced conditions and provides suggestions for future research.

A Real-World Study on Myopia Control 6 Months After Withdrawal of 1% Atropine Eye Gel

Purpose: This study aimed to observe the changes in spherical equivalent and ocular axial length 6 months after withdrawal of 1% atropine eye gel.Methods: Due to COVID-19, the follow-up of patients in our optometric clinic who were undergoing myopia control treatment with a dropwise 1% atropine “5+3” regimen was interrupted. No return visit was made after the 3 months of at-home treatment, and follow-ups resumed 6 months after treatment withdrawal. The contralateral eye was not treated over the 9-month period. A total of 16 patients aged 11.5 years (average) were enrolled from November 2019 to March 2021 during the COVID-19 pandemic. The treated eyes formed a treatment group (16 eyes) and the contralateral eyes formed a control group (16 eyes). The changes in spherical equivalent, ocular axial length, and intraocular pressure (IOP) were compared between groups. Results: After 9 months, the changes in spherical equivalent were significantly less in the treatment group (0.00 ± 0.20 [D]) compared to the control group (-0.67 ± 0.25 [D]) (P<0.05). The ocular axial length changes were significantly less in the treatment group (0.00 ± 0.06 mm) compared to the control group (0.25 ± 0.11 mm) (P<0.05). There was no significant difference between the two groups for changes in IOP. Conclusions: Despite treatment withdrawal after 3 months, treatment with 1% atropine eye gel successfully controlled myopia progression in the 6 months after withdrawal, as evidence by no rebound increase in myopic spherical equivalent after the withdrawal.

The Holocene Glacial History of Dart Glacier, Southern Alps, New Zealand

<p>Mountain glaciers are sensitive climate indicators, as climate variability drives mass changes that are expressed in glacier length fluctuations. These length changes are preserved in the geological record, thus offering the potential to generate new palaeoclimate proxy data that can be used to extend instrumental climate records. This study presents geomorphological mapping and cosmogenic ¹⁰Be surface exposure dating of the Holocene moraines at Dart Glacier, New Zealand. These findings show that an early Holocene advance (~6 km longer than present-day) took place ~7817 ± 336 years ago. Moraine ages also show that a more restricted glacier readvance (~4 km longer than present-day) occurred ~321 ± 44 years ago. Through better constraining the timing and magnitude of Holocene glacier length changes, we extend the ~100-year history of observational records in the upper Dart valley. Net retreat of Dart Glacier during the Holocene is consistent with other moraine chronologies from New Zealand, which supports existing hypotheses that suggest summer insolation was the dominant driver of multi-millennial climate change at southern mid-latitudes during the current interglacial. Individual moraine forming events at Dart Glacier also coincide with moraine ages from several other catchments in the Southern Alps and likely reflect shorter-term (decadal-centennial-scale) climatic changes. The new geological record constraints of length changes at Dart Glacier offer the opportunity to test such hypotheses more formally using physics-based modelling. Connecting Holocene moraine records to historical glacier observations using ¹⁰Be surface exposure dating requires consistently low background levels of this rare isotope. Systematic blank experiments show that concentrated analytical grade hydrofluoric acid and reused beakers are likely the largest contributors of ¹⁰Be to the average process blank in the VUW Cosmogenic Laboratory. Based on these findings I recommend small methodological improvements that could be implemented to lower process blank ratios for routine application of ¹⁰Be surface exposure dating to near-historic glacial landforms.</p>

The Holocene Glacial History of Dart Glacier, Southern Alps, New Zealand

<p>Mountain glaciers are sensitive climate indicators, as climate variability drives mass changes that are expressed in glacier length fluctuations. These length changes are preserved in the geological record, thus offering the potential to generate new palaeoclimate proxy data that can be used to extend instrumental climate records. This study presents geomorphological mapping and cosmogenic ¹⁰Be surface exposure dating of the Holocene moraines at Dart Glacier, New Zealand. These findings show that an early Holocene advance (~6 km longer than present-day) took place ~7817 ± 336 years ago. Moraine ages also show that a more restricted glacier readvance (~4 km longer than present-day) occurred ~321 ± 44 years ago. Through better constraining the timing and magnitude of Holocene glacier length changes, we extend the ~100-year history of observational records in the upper Dart valley. Net retreat of Dart Glacier during the Holocene is consistent with other moraine chronologies from New Zealand, which supports existing hypotheses that suggest summer insolation was the dominant driver of multi-millennial climate change at southern mid-latitudes during the current interglacial. Individual moraine forming events at Dart Glacier also coincide with moraine ages from several other catchments in the Southern Alps and likely reflect shorter-term (decadal-centennial-scale) climatic changes. The new geological record constraints of length changes at Dart Glacier offer the opportunity to test such hypotheses more formally using physics-based modelling. Connecting Holocene moraine records to historical glacier observations using ¹⁰Be surface exposure dating requires consistently low background levels of this rare isotope. Systematic blank experiments show that concentrated analytical grade hydrofluoric acid and reused beakers are likely the largest contributors of ¹⁰Be to the average process blank in the VUW Cosmogenic Laboratory. Based on these findings I recommend small methodological improvements that could be implemented to lower process blank ratios for routine application of ¹⁰Be surface exposure dating to near-historic glacial landforms.</p>

Experimental investigation on adhesive bonding of similar and dissimilar weld joint used for automotive applications

The automobile industry has started using adhesive bonding to join load bearing components which aerospace industry has been using for decades. Adhesive lap joints are used frequently in the manufacture of automobile. In present study, structural adhesives were used to join the aluminium alloy (AA5083 H111) with the HSS dual phase (DP780) steel. Adhesive bonding appears to be one of the appropriate methods of joining dissimilar materials. The aim of this work is to analyze the tensile strength of similar and dissimilar joints. The influence of various parameters was also investigated such as the overlap length and the bondline thickness of specimens. In DP steel, there is 22% increase in strength for similar lap joint when overlap length changes from 10 mm to 15 mm, while there is 45% increase in strength when it varies from 15 mm to 20 mm. Similarly in case of Al alloy, there is 26% increased strength for similar lap joints when length varies from 10 mm to 15 mm, while it increased to 42% when length changes from 15 mm to 25 mm and there is about 35% increase in strength for length varies from 20 mm to 25 mm. In case of dissimilar joints, firstly there is about 16% increase in strength then there is 5% decrease while after that there is 45% increase in strength. Adhesion failure, cohesion failure and mixed failure were obtained experimentally during failure mode analysis. As the strength of joint increases, failure mode shows a transition from adhesion failure to cohesion failure. From the literature survey it is evident that limited work has been carried out on analysis of shear-tensile strength of adhesively bonded steel and aluminium joint with variation in bonding parameters. Not much work on failure mode analysis of bonded joints during tensile testing has been reported. In present work a noval attempt has been made to analyze the shear-tensile strength and failure mode of adhesively bonded steel and aluminium joint with variation in bonding parameters.