Triglyceride Glucose-Body Mass Index is a Reliable Indicator of Bone Mineral Density and Risk of Osteoporotic Fracture in Middle-Aged and Elderly Nondiabetic Chinese Individuals

Purpose: This study aimed to investigate the relationship of triglyceride glucose-body mass index (TyG-BMI) with bone mineral density, femoral neck geometry, and risk of fracture in middle-aged and elderly Chinese individuals. Methods: A total of 832 nondiabetic individuals (474 men aged ≥50 years and 358 postmenopausal women) were selected from the prospective population-based HOPE cohort. All individuals underwent dual-energy X-ray absorptiometry for assessment of bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip, as well as femoral neck geometry. The 10-year probabilities of major osteoporotic fractures (MOFs) and hip fractures (HFs) were calculated. Correlations of TyG-BMI with BMD at different sites, femoral neck geometry, and risk of fractures were examined in men and women. Results: Cortical thickness (CT), compression strength index (CSI), cross-sectional moment of inertia (CSMI), cross-sectional area (CSA), section modulus (SM), and 25(OH)D levels were significantly lower in women (all P < 0.001). The presence of osteoporosis was related to age, BMI, BMD and femoral neck geometry, TyG-BMI index and TyG index, MOF and HF in both sex. TyG-BMI was positively correlated with BMD at femoral neck, lumber spine, and total hip and with femoral neck geometry parameters in men, Similar significant association was also present in women. In men, TyG-BMI showed significant negative correlation with HF but not with MOF. In women, TyG-BMI showed significant negative correlation with both factors only after adjusting for other variable. The various geometric indices of the femoral neck were 3 significantly impaired in individuals with low TyG-BMI. the TyG-BMI index was found to be significantly associated with osteoporosis after adjusting for confounders. Conclusion: TyG-BMI is positively associated with BMD and femoral neck geometry, and negatively associated with risk of fracture in nondiabetic middle-aged and elderly Chinese men and women.