Associations between dietary fatty acid patterns and cognitive function in the Hispanic Community Health Study/Study of Latinos

Our objective was to quantify the cross-sectional associations between dietary fatty acid (DFA) patterns and cognitive function among Hispanic/Latino adults. This study included data from 8,942 participants of the Hispanic Community Health Study/Study of Latinos, a population-based cohort study (weighted age 56.2 y and proportion female 55.2%). The NCI (National Cancer Institute) method was used to estimate dietary intake from two 24-hr recalls. We derived DFA patterns using principal components analysis with 26 fatty acid and total plant and animal monounsaturated fatty acid (MUFA) input variables. Global cognitive function was calculated as the average z-score of 4 neurocognitive tests. Survey linear regression models included multiple potential confounders such as age, sex, education, depressive symptoms, physical activity, energy intake, and cardiovascular disease. DFA patterns were characterized by consumption of long-chain saturated fatty acids (SFA), animal-based MUFA, and trans fatty acids (Factor 1); short to medium-chain SFA (Factor 2); very-long-chain omega-3 polyunsaturated fatty acids (PUFA) (Factor 3); very-long-chain SFA and plant-based MUFA and PUFA (Factor 4). Factor 2 was associated with greater scores for global cognitive function (β=0.037 ± 0.012) and the Digit Symbol Substitution (DSS) (β=0.56±0.17), Brief Spanish English Verbal Learning-Sum (B-SEVLT) (β=0.23 ± 0.11), and B-SEVLT-Recall (β=0.11 ± 0.05) tests (P<0.05 for all). Factors 1 (β=0.04 ± 0.01) and 4 (β=0.70 ± 0.18) were associated with the DSS test (P<0.05 for all). Consumption of short to medium-chain SFA may be associated with higher cognitive function among U.S.-residing Hispanic/Latino adults. Prospective studies are necessary to confirm these findings.

Even-Chain UFA Pattern, n-3 Long-Chain PUFA Pattern and Risk of Esophageal Squamous Cell Carcinoma in Southeast of China

Objective: To characterize and examine associations between dietary fatty acid intake patterns and the risk of esophageal squamous cell carcinoma (ESCC).Methods: A total of 422 patients and 423 controls were recruited. Dietary fatty acids, as a percentage of total fat, were entered into a factor analysis. Multinomial logistic regression and restricted cubic spline were used to evaluate the risk of ESCC specific for different dietary fatty acid patterns (FAPs). A forest plot was applied to show the potential effect modification.Results: The factor analysis generated 4 major fatty acid patterns: a long-chain SFA (LC-SFA) pattern; an even-chain unsaturated fatty acid (EC-UFA) pattern; a short and medium-chain SFA (SMC-SFA) pattern, and an n-3 long-chain polyunsaturated fatty acid (n-3 LC-PUFA) pattern. In the multivariate-adjusted model, the odds ratios (ORs) with 95% confidence interval (CI) of ESCC were 2.069(1.314,3.257), and 0.525 (0.340–0.811) for the highest versus the lowest tertile of EC-UFA pattern and n-3 LC-PUFA pattern, respectively. The LC-SFA, SMC-SFA patterns were not associated with ESCC. There existed a nonlinear positive association between the EC-UFA pattern and the risk of ESCC (p for nonlinearity <0.05), nevertheless, there was a nonlinear negative association between the n-3 LC-PUFA pattern and the risk of ESCC (p for nonlinearity <0.001). Multiplicative interaction between fried food, pickled food, hard food, tobacco smoking, alcohol drinking, and four FAPs was also observed.Conclusions: Our study indicates that EC-UFA pattern, n-3 LC-PUFA pattern intake are associated with ESCC, which might provide a potential dietary intervention for ESCC prevention.

Increased postprandial nonesterified fatty acid efflux from adipose tissue in prediabetes is offset by enhanced dietary fatty acid adipose trapping

The mechanism of increased postprandial nonesterified fatty acid (NEFA) appearance in the circulation in impaired glucose tolerance (IGT) is due to increased adipose tissue lipolysis but could also be contributed to by reduced adipose tissue (AT) dietary fatty acid (DFA) trapping and increased 'spillover' into the circulation. Thirty-one subjects with IGT (14 women, 17 men) and 29 with normal glucose tolerance (NGT, 15 women, 14 men) underwent a meal test with oral and intravenous palmitate tracers and the oral [18F]-fluoro-thia-heptadecanoic acid positron emission tomography method. Postprandial palmitate appearance (Rapalmitate) was higher in IGT vs. NGT (P < 0.001), driven exclusively by Rapalmitate from obesity-associated increase in intracellular lipolysis (P = 0.01), as Rapalmitate from DFA spillover was not different between the groups (P = 0.19) and visceral AT DFA trapping was even higher in IGT vs. NGT (P = 0.02). Plasma glycerol appearance was lower in IGT (P = 0.01), driven down by insulin resistance and increased insulin secretion. Thus, we found higher AT DFA trapping, limiting spillover to lean organs and in part offsetting the increase in Rapalmitate from intracellular lipolysis. Whether similar findings occur in frank diabetes, a condition also characterized by insulin resistance but relative insulin deficiency, requires further investigation (Clinicaltrials.gov: NCT04088344, NCT02808182).