ultrasound microscopy
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2021 ◽  
Vol 30 (4) ◽  
pp. e183
Author(s):  
Ryuzo Arai ◽  
Yoshihiro Hagiwara ◽  
Yoshifumi Saijo ◽  
Shuichi Matsuda

2021 ◽  
Author(s):  
Congcong Wang ◽  
Lili Guo ◽  
Guan Wang ◽  
Tong Ye ◽  
Bo Wang ◽  
...  

Acoustics ◽  
2020 ◽  
Vol 3 (1) ◽  
pp. 3-10
Author(s):  
Hideki Kumagai ◽  
Kazuto Kobayashi ◽  
Sachiko Yoshida ◽  
Koji Yokoyama ◽  
Norio Hirota ◽  
...  

Scanning acoustic microscopy reveals information on histology and acoustic impedance through tissues. The objective of the present study was to investigate whether acoustic impedance values in the liver over time reflect the progression of steatohepatitis through different grades and stages, and whether this approach can visualize histologic features of the disease. Mice were divided into two groups: a control group and a steatohepatitis group prepared by keeping the mice on a methionine and choline-deficient diet for 56 weeks. The hepatic lobe was excised for measurement of impedance and observation of microscopic structure using a commercially available scanning acoustic microscopy system with a central frequency of 320 MHz. Scanning acoustic microscopy revealed that acoustic impedance through liver tissue with steatohepatitis temporarily decreased with the degree of fat deposition and then increased in parallel with the progression of inflammation and fibrosis. However, the acoustic images obtained did not allow discrimination of detailed microstructures from those seen using light microscopy. In conclusion, estimation of acoustic impedance appears to have potential clinical applications, such as for monitoring or follow-up studies.


2020 ◽  
Vol 19 ◽  
pp. 100178
Author(s):  
Héctor Estrada ◽  
Johannes Rebling ◽  
Urs Hofmann ◽  
Daniel Razansky

2020 ◽  
Vol 40 (5) ◽  
pp. 707-718 ◽  
Author(s):  
Sunghun Park ◽  
Sungwoo Kang ◽  
Jin Ho Chang

Abstract Purpose Photoacoustic (PA) microscopy has emerged as a useful tool in biomedical imaging applications such as visualization of microvasculature and hemoglobin oxygen saturation, single-cell, and label-free imaging of organs including cancer. Since the ultrasound transducers used for PA signal detection are not optically transparent, the integration of optical and acoustic modules for coaxial alignment of laser and acoustic beam fields in PA microscopy is complex and costly. Methods Here, we report a recently developed optically transparent focused transducer for combined PA and ultrasound (US) microscopy. All the acoustic layers including the acoustic lens are optically transparent, enabling simple integration of optical and acoustic modules for both imaging modalities. Results The mean light transmittance of the transducer’s backing layer and acoustic lens and of the transducer itself were measured at 92%, 83%, and 66%, respectively. Results from in vitro and in vivo experiments demonstrated the transducer to be suitable for both US and PA imaging. Conclusions The results of this study represent a step toward efficient construction of probes for combined PA and US microscopy.


2019 ◽  
Vol 23 (6) ◽  
pp. 867-869 ◽  
Author(s):  
Takane Ito ◽  
Takahiro Kanai ◽  
Norio Hirota ◽  
Kouichi Itoh ◽  
Takanori Yamagata

2019 ◽  
Vol 25 (3) ◽  
pp. 347-354
Author(s):  
Tomoko Sugawara ◽  
Noriaki Nakagawa ◽  
Norio Shimizu ◽  
Nami Hirai ◽  
Yoshifumi Saijo ◽  
...  

2018 ◽  
Vol 89 (7) ◽  
pp. 073705
Author(s):  
Xiaoyu Yang ◽  
Anyu Sun ◽  
Bing-feng Ju ◽  
Shaoning Xu

2018 ◽  
Vol 34 (7) ◽  
pp. 1036-1040
Author(s):  
Mareike Warkentin ◽  
Cora Freyse ◽  
Olaf Specht ◽  
Detlef Behrend ◽  
Reinhard Maletz ◽  
...  

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