Acute localized exanthematous pustulosis: A novel side effect of piroxicam

Acute generalized exanthematous pustulosis (AGEP) is a rare yet well-known cutaneous reaction pattern, mostly caused by drugs. Acute localized exanthematous pustulosis (ALEP) is a localized variant of AGEP. A 42-year-old female presented with multiple erythematous pustules on the face, which appeared three days after the intramuscular injection of piroxicam. Histopathology revealed subcorneal pustules, epidermal spongiosis, and mixed inflammatory cell infiltration in the dermis. The pustules resolved within several days once the patient had discontinued the drug. Herein, we report the first case, as far as we know, of a female with a cutaneous drug reaction consistent with ALEP caused by piroxicam.

Unusual Cutaneous Reaction at Site of Methotrexate Injection in Two Patients with Psoriasis and Psoriatic Arthritis

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Cutaneous reaction to sea urchin spines

A 35-year-old male returned from vacation in Hawaii where he went scuba diving and snorkeling. While snorkeling, he stepped on a sea urchin and sustained injuries to the dorsal aspect of his right foot. He began to swim back to shore when he felt significant pain and began removing visible spines when he reached shore. He saw a physician in Hawaii who removed remaining spines and started a treatment regimen of cephalexin 500 mg QID. Patient followed up 2 weeks later with his home dermatologist for persistent granuloma and was given 15-day course of oral doxycycline 50 mg BID with near full recovery within 2 weeks. Even physicians practicing inland need to be aware of coastal injuries and reactions as they can mimic other common skin tumors such as keratoacanthomas.