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2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Boghuma K. Titanji ◽  
Marta Gwinn ◽  
Vincent C. Marconi ◽  
Yan V. Sun

AbstractDespite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the host epigenome and as such can impact disease progression, as well as the molecular processes driving non-AIDS comorbidities in PWH. Epigenetic epidemiologic studies including epigenome-wide association studies (EWAS) offer a unique set of tools to expand our understanding of HIV disease and to identify novel strategies applicable to treatment and diagnosis in this patient population. In this review, we summarize the current state of knowledge from epigenetic epidemiologic studies of PWH, identify the main challenges of this approach, and highlight future directions for the field. Emerging epigenetic epidemiologic studies of PWH can expand our understanding of HIV infection and health outcomes, improve scientific validity through collaboration and replication, and increase the coverage of diverse populations affected by the global HIV pandemic. Through this review, we hope to highlight the potential of EWAS as a tool for HIV research and to engage more investigators to explore its application to important research questions.


2022 ◽  
pp. 101-118
Author(s):  
Ankita Gautam

Phytochemicals have recently been studied in vivo for their unmatched interactions in curing lethal diseases that can't be cured by allopathic medical intervention without any adverse effect on the patient health. These methods were being used in ancient India, where Jamun and Giloy have been used to decrease hormonal imbalance and pathological disorders. Signaling pathways of the active components of Tinospora cordifolia thus enable effective disease targeting. With so much to offer to the scientific world of medicine, the plant Tinospora truly acts as an incredible source as it deals with seasonal fever like Dengue, Malaria, Chickengunia, and anticancer and anti-HIV (research undergoing). Whereas the Syzygium cumini (Jamun) fruit and seed hold worth in treating various diet-related malfunctions, especially hyperglycemia. In the current research, Jamun seed and fruit extracts have been proved effective in the regulation of blood glucose and insulin parameters.


2021 ◽  
Vol 21 (4) ◽  
pp. 1615-20
Author(s):  
Anthony Kiwanuka ◽  
Eddy Walakira ◽  
David Kaawa-Mafigiri

The issue of HIV and AIDS and people living with HIV and AIDS is very sensitive which needs great attention. The population of infected individuals seems not to seek help and health services due to their illness. The barriers which prevent this population experience the meaning of social construction of their illness. The main objective of this study is to understand the day-to-day lives and the ways PLWHA deals with their lives. Qualitative method and participatory action research were used to gather information. The study found out that PLWHA have much to fight for in the complex and frightening areas of HIV research and treatment. Though there have been lacking scientific skills, all PLWHA can bring unique experiences and perspectives to an open discussion. The study concluded that facing the challenges of working with HIV and AIDS–individuals; consider the participatory research approach because it can reach out to individuals, groups and organizations.It was recommended that the ultimate goals of AIDS treatment and research activism are to accelerate scientific research knowledge that contributes towards cure, and to win an early widespread access to treatment for everyone infected with HIV. Developing a well-designed research can help PLWHA learn how to ask themselves different questions and ask if the medical and research establishments will address their concerns. Keywords: Health Services;, seeking behavior; persons living with HIV.


Author(s):  
Andrea R. Kaniuka ◽  
Meagan Zarwell ◽  
Robert J. Cramer ◽  
Katherine Quinn ◽  
Michelle Broaddus ◽  
...  

Human immunodeficiency virus (HIV) continues to disproportionately affect gay, bisexual, and other men who have sex with men (GBM) and transgender and nonbinary (trans/NB) individuals. This study investigated attitudes toward participation in HIV survey research, guided by Emanuel's framework for ethical clinical research (e.g., risk–benefit ratio, fair participant selection, respect for participants, social value, and collaborative partnership). GBM ( n = 294) and trans/NB ( n = 86) persons recruited at a Pride event in Milwaukee completed a survey assessing risks and benefits of participation in, and comfort responding to, sexual health surveys. Participants reported few ethical concerns (e.g., privacy and confidentiality), with notable differences by race, sexual orientation and gender identity, and prior research experiences. Implications for HIV research with GBM and trans/NB individuals are discussed.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 220-221
Author(s):  
Paul Nash ◽  
Molly Perkins

Abstract Those over the age of 50 represent the majority of people living with HIV (PWH), most of the HIV research, prevention and service retention work is targeted at ‘at-risk’ communities under age 50. Given this diverse and growing population, intersections of age with HIV need to be prioritized. This focus would actively increase quality of care and life experience for older PWH and the growing numbers transitioning into old age. Using local, national, and international data, this symposium will highlight the unmet social needs of older PWH. Presentations will provide evidence of unmet need, decreased self-esteem, enhanced health burden, and the damaging nature of stigma. Given the impact of COVID-19 globally, the data will further demonstrate the need to support immunocompromised older PWH. Older PWH are a marginalized community and the effects of COVID-19 have been disproportionately severe. With the adverse health outcomes experienced because of COVID-19 and intersectional stigma, it is important to understand the support structures that are and are not in place for older PWH. Advance care directives make up an integral part of future planning, especially for those living with chronic health concerns, yet little research has previously evidenced the steps taken by OPWH. Finally, using data from sub-Saharan Africa, emotional and instrumental social support sufficiency will be described to highlight the unmet needs of these older PWH. Our discussion will focus on the need for policies and programs to support this growing segment of the HIV population with increasingly diverse and unmet needs.


2021 ◽  
Vol 21 (12) ◽  
pp. 1640
Author(s):  
Udani Samarasekera
Keyword(s):  

2021 ◽  
Vol 33 (6) ◽  
pp. 465-482
Author(s):  
Sameena Azhar ◽  
Xiangyu Tao ◽  
Vaidehi Jokhakar ◽  
Celia B. Fisher

We collected 216 responses from sexually active MSM, transgender women, and gender-nonconforming (GNC) people of color through a web-based survey to understand the facilitators and barriers to research participation in a hypothetical LAI PrEP trial. In adjusted models, these items were found to be significantly associated with research participation likelihood: ever participated in HIV research study; comfort with taking daily pill; comfort with providing urine sample; and concerns over potential side effects of shot. Asian participants were more concerned about others knowing they were being recruited than were Black and Latinx respondents F(2, 216) = 3.98; p < .05. Asian respondents were also less comfortable with being recruited at organizations serving communities of color than Black and Latinx respondents, F(2, 216) = 5.10; p < .05. Cisgender respondents were more comfortable with being recruited by a friend or colleague than were transgender/GNC respondents, F(1, 215) = 4.8; p < .05.


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Hussein Ali El-Khechen ◽  
Mohammed Inam Ullah Khan ◽  
Selvin Leenus ◽  
Oluwatobi Olaiya ◽  
Zoha Durrani ◽  
...  

Abstract Background Pilot studies are essential in determining if a larger study is feasible. This is especially true when targeting populations that experience stigma and may be difficult to include in research, such as people with HIV. We sought to describe how pilot studies have been used to inform HIV clinical trials. Methods We conducted a methodological study of pilot studies of interventions in people living with HIV published until November 25, 2020, using Medline, Embase, and Cochrane Controlled Register of Trials (CENTRAL). We extracted data on their nomenclature, primary objective, use of progression criteria, sample size, use of qualitative methods, and other contextual information (region, income, level, type of intervention, study design). Results Our search retrieved 10,597 studies, of which 248 were eligible. The number of pilot studies increased steadily over time. We found that 179 studies (72.2%) used the terms “pilot” or “feasibility” in their title, 65.3% tested feasibility as a primary objective, only 2% used progression criteria, 23.9% provided a sample size estimation and only 30.2% used qualitative methods. Conclusions Pilot studies are increasingly being used to inform HIV research. However, the titles and objectives are not always consistent with piloting. The design and reporting of pilot studies in HIV could be improved.


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