Hyperhomocysteinemia as an Independent Risk Factor for Coronary Heart Disease. Comparison with Conventional Risk Factors

The present study was designed to evaluate the strength of association of raised plasma homocysteine concentration as a risk factor for coronary heart disease independent of conventional risk factor. It was a case control study conducted at Punjab Institute of Cardiology Lahore. A total of 210 subjects aged 25 to 60 years comprising of 105 newly admitted patients of CHD as cases and 105 age and sex matched healthy individuals with no history of CHD as control were recruited for the study. Fasting blood samples were obtained from cases and controls. Plasma homocysteine was analyzed by fluorescence polarization immunoassay (FPIA) method on automated immunoassay analyzer (Abbott IMX). Total cholesterol, triglyceride and HDL cholesterol were analyzed using calorimetric kit methods. The concentration of LDL cholesterol was calculated using Friedewald formula. The patients were also assessed for traditional risk factors such as age, sex, family history of CVD, hypertension, smoking and physical activity, and were compared with control subjects. The collected data was entered in SPSS version 24 for analysis and interpretation.The mean age in controls and experimental groups were 43.00± 8.42 years and 44.72± 8.59 years with statistically same distribution (p- value= 0.144). The mean plasma homocysteine for cases was 22.33± 9.22 µmol/L where as it was 12.59±3.73 µmol/L in control group. Highly significant difference was seen between the mean plasma level of homocysteine in cases and controls (p˂0.001).Simple logistic regression indicates a strong association of coronary heart disease with hyperhomocysteinemia (OR 7.45), which remained significantly associated with coronary heart disease by multivariate logistic regression (OR 7.10, 95%C1 3.12-12.83, p=0.000). The present study concludes that elevated levels of Plasma homocysteine is an independent risk factor for coronary heart disease independent of conventional risk factors and can be used as an indicator for predicting the future possibility for the onset of CVD.

Genetic variations and phylogenetic relationship of genus Uromastyx from Punjab Pakistan

During the present study, specimens were collected from selected sites of Cholistan desert and Kalabagh Game Reserve, Punjab province, Pakistan. Each captured specimen was tagged with voucher number and morphometric measurements were taken. The average snout to vent length was 172.559±1.40 mm and average weight was 92.1±1.30 g. The DNA of Uromastyx hardwickii was amplified and sequenced using 16S rRNA primer set. The obtained DNA sequence has shown reliable and clear species identification. After trimming ambiguous bases, the obtained 16S rRNA fragment was 520 bp while 16S rRNA fragments aligned with closely matched sequence from NCBI comprised of 510 bp. Closely matched sequences of genus Uromastyx were retrieved from NCBI in blast searches. Neighbour-joining tree of genus Uromastyx was constructed based on p-distance using MEGA X. The mean intraspecific variation was 0.095±0.01 while intraspecific variation was ranging from 0-1%. Similarly, interspecific variation of Uromastyx hardwikii with Saara asmussi, Uromastyx alfredschmidti, Uromastyx geyri, Uromastyx thomasi, Uromastyx alfredschmidti was 0-12%, 0-19%, 0-19%, 0-20%, 12-19% respectively. The newly produced DNA was submitted to NCBI and accession number was obtained (MW052563.1). Results of current study provided information about the molecular and morphological identification of Genus Uromastyx. In our recommendation, comprehensive molecular based identification of Pakistan’s reptiles is required to report any new or subspecies from country.

Application of improved convolution neural network in financial forecasting

Financial status and its role in the national economy have been increasingly recognized. In order to deduce the source of monetary funds and determine their whereabouts, financial information and prediction have become a scientific method that can not be ignored in the development of national economy. This paper improves the existing CNN and applies it to financial credit from different perspectives. Firstly, the noise of the collected data set is deleted, and then the clustering result is more stable by principal component analysis. The observation vectors are segmented to obtain a set of observation vectors corresponding to each hidden state. Based on the output of PCA algorithm, we recalculate the mean and variance of all kinds of observation vectors, and use the new mean and covariance matrix as credit financial credit, and then determine the best model parameters.The empirical results based on specific data from China's stock market show that the improved convolutional neural network proposed in this paper has advantages and the prediction accuracy reaches.

Prevalence and Severity of Asthma, Rhinitis and Eczema in Pre-School Children in the United Arab Emirates

Very few studies have been carried out on asthma and allergies in pre-schoolchildren. This is the first study of pre-school children with asthma and allergies in the United Arab Emirates. We studied 4,000 pre-schoolchildren from the United Arab Emirates: Dubai, Sharjah, Abu Dhabi, and Al-Ain. The ages of the study group were between 1-5 years, and were 2,000 boys and 2,000 girls; they were randomly selected from kindergartens and nurseries. We used the standardised International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. The mean (SD) age, height, weight and BMI were 3.3 (1.4) years, 92.0 (1.3) cm, 17.3 (5.2) kg, and 23.4 (9.3). The prevalence rates of “wheeze ever”, “current wheeze”, “speech limitation”, “asthma” , “dry night cough”, and “exercise-induced asthma” were 40.4%, 43.8%, 37.6%, 26.5%, 36.1, and 37.6%, respectively. Boys had a significantly higher prevalence of wheeze ever and current wheeze than girls. Girls had a significantly higher prevalence of speech limitation than boys. The prevalence rates of “rhinitis ever”, “current rhinitis”, “itchy watery eyes” and “hay fever” were 42%, 40.5%, 39.1% and 46.9%, respectively. Boys had significantly higher prevalence rates of “rhinitis ever”, “current rhinitis”, and “itchy watery eyes” than girls. The prevalence rates of “rash ever”, “current rash” and “eczema ever” were 38.9%, 33.7% and 58.0%, respectively. Boys had significantly higher prevalence rates of rash ever, current rash, and eczema ever than girls. Children who were exposed to parental smoking have significantly higher prevalence rates of asthma, wheezing, and cough than those whom were not exposed. Children who breastfed more than 10 months had a significantly lower prevalence rates of “wheeze ever”, “current wheeze”, “speech limitation”, and “asthma”, than those whom breastfed less than 10 months. The prevalence rates of asthma, rhinitis and eczema were very high. Breastfeeding was found to be protective for asthma. The study can be used as a baseline intervention project to reduce incidents of asthma and allergies in these children and to establish atopic march in order to implement strategies to improve the respiratory health and allergies in these children. Keywords: asthma, wheeze, night cough, rhinitis, eczema, pre-school children, paediatric asthma

The Effects of Emotional Schema Therapy and Differentiation Training on Emotional Divorce in Women

Background: Emotional Divorce (ED) is associated with decreased levels of Emotion Regulation (ER), adaptation, and mental health; subsequently, all such pressures raise stress in various dimensions among the affected individuals. Emotional Schema Therapy (EST), as a socio-cognitive model of ER, may improve marital intimacy and reduce couples’ psychological distress. The present study aimed to investigate the effects of EST and differentiation training on the odds of ED among women. Methods: The mean values of ED significantly decreased in both experimental groups, compared to the control group (P<0.05). A significant difference was also observed between the effects of the two interventions on decreasing the ED rate; thus, the effectiveness of EST was greater than that of differentiation training in this respect (P<0.05). Results: The mean values of ED significantly decreased in both experimental groups, compared to the control group (P<0.05). A significant difference was also observed between the effects of the two interventions on decreasing the ED rate; thus, the effectiveness of EST was greater than that of differentiation training in this respect (P<0.05). Conclusion: EST and differentiation training reduced ED among the study participants. These approaches can be adopted as an effective intervention to solve the couples’ problems and improve their marital relationship to reduce the odds of emotional divorce.

Genotoxic and cytotoxic evaluation of venlafaxine in an acute and a subchronic assay in mouse

The present research was made to determine the micronuclei and cytotoxic capacity of the antidepressant venlafaxine in an in vivo acute and subchronic assays in mouse. In the first study, we administered once 5, 50, and 250 mg/kg of the drug, and included a negative and a daunorubicin treated group. Observations were daily made during four days. The subchronic assay lasted 5 weeks with daily administration of venlafaxine (1, 5, and 10 mg/kg) plus a negative and an imipramine administered groups. Observations were made each week. In the first assay results showed no micronucleated polychromatic erythrocytes (MNPE) increase, except with the high dose at 72 h. The strongest cytotoxic effect was found with 250 mg/kg at 72 h (a 51% cytotoxic effect in comparison with the mean control level). In the subchronic assay no MNPE increase was found; however, with the highest dose a significant increase of micronucleated normochromatic erythrocytes was observed in the last three weeks (a mean of 51% respect to the mean control value). A cytotoxic effect with the two high doses in the last two weeks was observed (a polychromatic erythrocyte mean decrease of 52% respect to the mean control value). Results suggest caution with venlafaxine.

Near-infrared Reflective Diffusion Coating Is Beneficial for Asparagus Summer Production in a Simple Plastic Greenhouse

Asparagus is a potential greenhouse crop, and its production is considerably affected by temperature and light, especially in the summer season. This study investigated the effects of the application of near-infrared (NIR)-reflective diffusion coating on a simple plastic greenhouse on microclimatic conditions, plant response, spear yield, and quality of the asparagus plant in central Taiwan. The results showed that NIR-reflective diffusion coating reduced the mean air temperature inside the greenhouse by 0.3 to 0.9 °C and leaf temperature by 2.3, 2.4, and 2.4 °C at a canopy height of 50, 100, and 50 cm, respectively. Although the accumulated daily light integral (DLI) transmitted in the coated greenhouse exhibited an 18.9% reduction compared with a 16.8% reduction in the noncoated greenhouse, a more uniform spatial light distribution was noted. Therefore, photosynthesis improved in the middle and bottom canopy, and plants could maintain a higher transpiration rate, thus resulting in atmospheric cooling. The average spear yield increased by 31.4% in summer and by 10.1% during the following harvest with a lower crude fiber (CF) content and higher Ca as well as Mg contents. In addition, the number of newly emerged shoots increased by 48.8% after the removal of the mother stalk under coating. NIR-reflective diffusion coating can be used as an energy-saving method for enhancing cooling and improving light use efficiency, thus increasing asparagus production in a greenhouse in summer.

Perennial Flax: A Potential Cut Flower Crop

The genus Linum L. contains ≈200 primarily blue-flowered species, including several ornamentals, yet no reports exist regarding the cut flower potential of this genus. The objective of this study was to evaluate the cut flower potential of perennial flax cultivars (L. perenne L. ‘Blue Flax’ and ‘Sapphire’; Expt. 1, 2018) and accessions (L. austriacum L., L. lewisii Pursh., and L. perenne; Expt. 2, 2019), and record traits that will enable breeding and selection for improved cut flower performance. The mean vase life across both cultivars in Expt. 1 was 9.2 days. In Expt. 2, L. perenne had the longest average vase life (9.3 days), followed by L. austriacum (9.1 days) and L. lewisii (8.3 days). The floral preservative (Floralife 300) significantly increased vase life by an average of 1.7 days in Expt. 1, and 1.6 days in Expt. 2, and resulted in a significantly greater number of flowers (≈2x) in both experiments. Significant variation was observed among genotypes for most traits, including vase life (6.2 to 11.3 days) and number of flowers (1.3 to 10.5), highlighting the opportunities for improving the potential of cut flower perennial flax through breeding.