fucosylated haptoglobin
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2021 ◽  
Vol 27 (2) ◽  
pp. 162-175
Author(s):  
Kei Motooka ◽  
Koichi Morishita ◽  
Nami Ito ◽  
Shinichiro Shinzaki ◽  
Taku Tashiro ◽  
...  

2019 ◽  
Vol 9 (1) ◽  
pp. 31-37
Author(s):  
Nahla M. Shalably ◽  
Rehab Badawi ◽  
Nehad Hawash ◽  
Sherief Abd-Elsalam ◽  
Walaa Elkhalawany ◽  
...  

Background: Most Hepatocellular Carcinomas (HCCs) are diagnosed at an advanced stage. Therefore, there is citation-type an urgent need for better methods of detection and surveillance of patients at risk of HCC. Alpha-fetoprotein (AFP) has a suboptimal diagnostic performance for HCC surveillance, so novel and reliable diagnostic biomarkers are required. Objective: The aim of this work is to evaluate fucosylated haptoglobin as a diagnostic biomarker for hepatocellular carcinoma in Egyptian patients. Materials and Methods: This case-control study was carried out on 60 patients classified into 3 groups (20 patients on each); group I (HCC group), group II (Cirrhotic group) and group III (Control group). Diagnosis of liver cirrhosis was done by clinical, biochemical and ultrasound (US), whereas the diagnosis of HCC was done by percutaneous biopsy or radiological (by US and triphasic Computerized Tomography (CT) based on the guidelines of the American-Association for the Study of Liver Diseases. HCC stage was clinically defined according to the Barcelona Clinic Liver Cancer (BCLC) staging system. AFP & fucosylated haptoglobin levels were estimated in all groups. Results: There was a statistically significant positive correlation between serum fucosylated haptoglobin and tumor size in the HCC group. Serum fucosylated haptoglobin (at 116 U/ ml) showed sensitivity 80%, specificity 65%, positive predictive value 53% and negative predictive value 87% with AUC 0.786. Combination of serum fucosylated haptoglobin and serum AFP at (200 ng/ ml) increased sensitivity that reached 95%. Conclusion: Serum fucosylated haptoglobin may serve as a novel diagnostic biomarker for the detection of HCC with higher sensitivity than AFP.


Pancreatology ◽  
2019 ◽  
Vol 19 (4) ◽  
pp. 569-577 ◽  
Author(s):  
Masaki Kuwatani ◽  
Hiroshi Kawakami ◽  
Yoshimasa Kubota ◽  
Kazumichi Kawakubo ◽  
Yoichi M. Ito ◽  
...  

2018 ◽  
Vol 487 ◽  
pp. 84-89 ◽  
Author(s):  
Koichi Morishita ◽  
Nami Ito ◽  
Sayaka Koda ◽  
Megumi Maeda ◽  
Kotarosumitomo Nakayama ◽  
...  

2017 ◽  
Vol 8 (5) ◽  
pp. 887-893 ◽  
Author(s):  
Shuxin Shang ◽  
Wei Li ◽  
Xue Qin ◽  
Shu Zhang ◽  
Yinkun Liu

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0151828 ◽  
Author(s):  
Seiichi Tawara ◽  
Tomohide Tatsumi ◽  
Sadaharu Iio ◽  
Ichizou Kobayashi ◽  
Minoru Shigekawa ◽  
...  

Pancreatology ◽  
2016 ◽  
Vol 16 (2) ◽  
pp. 238-243 ◽  
Author(s):  
Makiko Ueda ◽  
Yoshihiro Kamada ◽  
Shinji Takamatsu ◽  
Mayuka Shimomura ◽  
Tomohiro Maekawa ◽  
...  

2015 ◽  
Vol 51 ◽  
pp. S534
Author(s):  
J.C. Villegas-Pineda ◽  
A. Toledo-Leyva ◽  
O.L. Garibay-Cerdenares ◽  
V.I. Hernández-Ramirez ◽  
D. Gallardo-Rincón ◽  
...  

2015 ◽  
Vol 446 ◽  
pp. 30-36 ◽  
Author(s):  
Mayuka Shimomura ◽  
Kotarosumitomo Nakayama ◽  
Kanako Azuma ◽  
Naoko Terao ◽  
Kimihiro Nishino ◽  
...  

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