vitamin c supplementation
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2022 ◽  
Author(s):  
Jingyi Ren ◽  
Jufeng Liang ◽  
Jiaqi Wang ◽  
Bowen Yin ◽  
Fan Zhang ◽  
...  

Abstract Background: Accumulating evidence indicates that ambient air pollution exposure is associated with the adverse effects of cardiovascular diseases (CVDs). Evidence on the health benefits of vitamin C supplementation in highly polluted areas has not been evaluated. Objectives: We aims to evaluate whether dietary vitamin C supplementation can improve cardiovascular health linked to PM exposure. Methods: A randomized double-blind crossover trial was performed in 58 health young adults in Shijiazhuang, China in 2018. All subjects were randomly assigned to vitamin C supplementation or placebo group for a week alternating with a two-week washout period. We measured blood pressure (BP), blood lipid, biomarkers of oxidative and biomarkers of inflammation. Linear mixed-effect model was applied to evaluate the effect of vitamin C supplementation on health outcomes.Results: During the intervention periods, the average concentration of PM2.5 and PM10 was 164.91μg/m3 and 327.05μg/m3, respective. Vitamin C supplementation was significantly associated with decrease in several inflammatory indicators and blood pressure, including 19.47% in interleukin-6 (IL-6), 17.30% in tumor necrosis factor-a (TNF-α), 34.01% in C-reactive protein (CRP), 3.37% in systolic blood pressure (SBP) and 6.03% in pulse pressure (PP). Further, glutathione peroxidase (GSH-Px) was significantly increased by 7.15%. The effect of nutritional intervention on other indicators were beneficial, but there was no statistical difference. Gender-subgroup analysis showed that vitamin C supplementation significantly reduced SBP by 3.31%, PP by 4.94%, IL-6 by 20.97%, TNF-α by 27.85% and CRP by 38.5% in males, and significantly reduced SBP by 3.65%, PP by 8.12%, IL-6 by 17.35% and CRP by 29.15% in females. In contrast, vitamin C supplementation significantly increased APOB by 6.28% and GSH-Px by 14.47% in female participants only. Conclusion: This study indicates that vitamin C supplementation may protect cardiovascular system against particulate matter (PM) exposure among healthy young adults in China.Clinical trial registration information: Identifier: ChiCTR2100051371. Registered 19 October 2018, https://www.chictr.org.cn.


2022 ◽  
Vol 335 ◽  
pp. 00007
Author(s):  
Dyah Nurul Afiyah ◽  
Irma Isnafia Arief ◽  
Tuti Suryati ◽  
Riska Nurtantyo Sarbini

Yoghurt is a functional drink that is beneficial to health. However, nutritional losses, e.g. vitamin C, occurs during the thermal process. Therefore, vitamin C supplementation is needed to replace the lost amount during processing by adding the extract of podang urang mango (Mangifera indica L.). The yoghurt was made by adding 3% (v/v) of starter culture (Lactobacillus delbrueckii subsp bulgaricus RRAM-01 and Streptococcus salivarus subsp thermophillus RRAM-01) and mango extract at 0%, 2%, 4%, 6%, 8% and 10% (v/v) in four replications. The determination of vitamin C content was performed using titration method. The results showed that heating process at 85-90 °C in 35 minutes lowered the amount of vitamin C in the final product. However, the addition of podang urang mango extract at 6%, 8% and 10% could increase the amount of vitamin C.


Author(s):  
Tahmina Afrose Keya ◽  
Anthony Leela ◽  
Kevin Fernandez ◽  
Nasrin Habib ◽  
Mumunur Rashid

Background: Respiratory tract infections are a primary cause of illness and mortality over the world. Objective: This study was aimed to investigate the effectiveness of vitamin C supplementation in preventing and treating respiratory tract infections. Methods: We used the Cochrane, PubMed, and MEDLINE Ovid databases to conduct our search. The inclusion criteria were placebo-controlled trials. Random effects meta-analyses were performed to measure the pooled effects of vitamin C supplementation on the incidence, severity, and duration of respiratory illness. Results: found ten studies that met our inclusion criteria out of a total of 2758.The pooled risk ratio (RR) of developing respiratory illness when taking vitamin C regularly across the study period was 0⸳94 (with a 95% confidence interval of 0⸳87 to 1⸳01) which found that supplementing with vitamin C lowers the occurrence of illness. This effect, however, was statistically insignificant (P= 0⸳09). This study showed that vitamin C supplementation had no consistent effect on the severity of respiratory illness (SMD 0⸳14, 95% CI -0⸳02 to 0⸳30: I2 = 22%, P=0⸳09). However, our study revealed that vitamin C group had a considerably shorter duration of respiratory infection (SMD -0⸳36, 95% CI -0⸳62 to -0⸳09, P = 0⸳01). Conclusion: Benefits of normal vitamin C supplementation for reducing the duration of respiratory tract illness were supported by our meta-analysis findings. Since few trials have examined the effects of therapeutic supplementation, further research is needed in this area.


Author(s):  
Shashikala Eda ◽  
Somnath Motgi ◽  
Rohith Singh ◽  
Vijay Raghawa Rao B. N.

Background: Diabetes mellitus (DM) is the most common non-communicable diseases in the present millennium which has become a global public health problem. The treatment of type 2 Diabetes mellitus (T2 DM) often is initiated with monotherapy of oral antidiabetic drugs (OADs), which often do not decrease the plasma sugar levels effectively and consistently that will reduce short term and long-term complications associated with T2 DM. Hence the current study is aimed to determine the effectiveness of vitamin C supplementation with standard OADs on glycemic control.Methods: This study consisted of 120 T2 DM patients with 80 males and 40 females with a mean age of 50.88 yrs were divided into four groups with equal number of males and females in each group depending upon the OADs they received in solo or with vitamin C for 12 weeks. After the written consent, a detail clinical history, clinical examination, biochemical investigations including fasting plasma sugar (FPS), post prandial plasma sugar (PPS), glycosylated hemoglobin (HBA1c), serum creatinine, serum electrolytes, chest X-ray PA view and standard ECG were done. Repeat FPS, PPS and HBA1c were done after 4, 8 and 12 weeks of study.Results: After 12 weeks of study FBS, PPS and HBA1c decreased significantly (p<0.01) in study groups (Metformin and teneligliptin with vitamin C) as compared to control groups (OADs without vitamin C). Vitamin C supplementation with OADs found to be effective, well tolerated and devoid of any side effects.Conclusions: OADs are effective and affordable hypoglycemic agents with vitamin C supplementation.


2021 ◽  
Vol 12 ◽  
Author(s):  
Nazanin Majidi ◽  
Faezeh Rabbani ◽  
Somayeh Gholami ◽  
Maryam Gholamalizadeh ◽  
Fatemeh BourBour ◽  
...  

IntroductionVitamin C has been reported to have beneficial effects on patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the effect of vitamin C supplementation on pathological parameters and survival duration of critically ill patients with COVID-19.MethodsThis clinical trial was conducted on 120 hospitalized critically ill patients infected with COVID-19. The intervention group (n = 31) received one capsule of 500 mg of vitamin C daily for 14 days. The control group (n = 69) received the same nutrition except for vitamin C supplements. Measurement of pathological and biochemical parameters was performed at baseline and after 2 weeks of the intervention.ResultsFollowing 2 weeks of vitamin C supplementation, the level of serum K was significantly lower in the patients compared with the control group (3.93 vs. 4.21 mEq/L, p &lt; 0.01). Vitamin C supplementation resulted in a higher mean survival duration compared with that of the control group (8 vs. 4 days, p &lt; 0.01). There was a linear association between the number of days of vitamin C intake and survival duration (B = 1.66, p &lt; 0.001). The vitamin C supplementation had no effect on blood glucose, mean arterial pressure, arterial blood gas (ABG) parameters, Glasgow Coma Scale (GCS), kidney function, cell blood count (CBC), hemoglobin (Hb), platelet (Plt), partial thromboplastin time (PTT), albumin, hematocrit (Hct), and other serum electrolytes including sodium (Na), calcium, and phosphorus (P).ConclusionThe present study demonstrated the potential of vitamin C supplementation in enhancing the survival duration of critically ill patients with COVID-19.Clinical Trial Registrationhttps://www.irct.ir/trial/55074, identifier IRCT20151226025699N5


2021 ◽  
Author(s):  
Pedro Luiz Pucci Figueiredo Carvalho ◽  
Pedro Henrique Ventura Almeida ◽  
William dos Santos Xavier ◽  
Igor Simões Tiagua Vicente ◽  
Matheus Gardim Guimarães ◽  
...  

2021 ◽  
Vol 2021 (11) ◽  
Author(s):  
Zahra Ali Padhani ◽  
Zorays Moazzam ◽  
Alina Ashraf ◽  
Hasana Bilal ◽  
Rehana A Salam ◽  
...  

2021 ◽  
Author(s):  
Jean-Rémi Lavillegrand ◽  
Lisa Raia ◽  
Tomas Urbina ◽  
Geoffroy Hariri ◽  
Paul Gabarre ◽  
...  

Abstract Background Vitamin C has potential protective effects through anti-oxydant and anti-inflammatory properties. However, the effect of Vitamin C supplementation on microvascular function and peripheral tissue perfusion in human sepsis remains unknown. We aimed to determine vitamin C effect on microvascular endothelial dysfunction and peripheral tissue perfusion in septic shock patients. Methods Patients with septic shock were prospectively included after initial resuscitation. Bedside peripheral tissue perfusion and skin microvascular reactivity in response to acetylcholine iontophoresis in the forearm area were measured before and 1 hour after intravenous Vitamin C supplementation (40 mg/kg). Norepinephrine dose was not modified during the studied period. Results We included 30 patients with septic shock. SOFA score was 11 [8–14], SAPS II was 66 [54-79] and in-hospital mortality was 33%. Half of these patients had vitamin C deficiency at inclusion. Vitamin C supplementation strongly improved microvascular reactivity (AUC 2263 [430-4246] vs 5362 [1744-10585] UI, p=0.0004). In addition, Vitamin C supplementation improved mottling score (p=0.06), finger-tip (p=0.0003) and knee capillary refill time (3.7 [2.6-5.5] vs 2.9 [1.9-4.7] s, p<0.0001), as well as and central-to-periphery temperature gradient (6.1 [4.9-7.4] vs 4.6 [3.4-7.0] °C, p<0.0001). The beneficial effects of Vitamin C were observed both in patients with or without Vitamin C deficiency. Conclusion In resuscitated septic shock patients, vitamin C supplementation improved peripheral tissue perfusion and microvascular reactivity whatever plasma levels of vitamin C.


Life ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1166
Author(s):  
Patrick Holford ◽  
Anitra C. Carr ◽  
Masuma Zawari ◽  
Marcela P. Vizcaychipi

Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin. Administration of intravenous vitamin C to patients with pneumonia and sepsis appears to decrease the severity of the disease and potentially improve survival rate. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes pneumonia, sepsis and acute respiratory distress syndrome (ARDS) in severe cases, and is referred to as coronavirus disease 2019 (COVID-19). Patients with COVID-19 infection also appear to have depleted vitamin C status and require additional supplementation of vitamin C during the acute phase of the disease. To date there have been 12 vitamin C and COVID-19 trials published, including five randomised controlled trials (RCTs) and seven retrospective cohort studies. The current level of evidence from the RCTs suggests that intravenous vitamin C intervention may improve oxygenation parameters, reduce inflammatory markers, decrease days in hospital and reduce mortality, particularly in the more severely ill patients. High doses of oral vitamin C supplementation may also improve the rate of recovery in less severe cases. No adverse events have been reported in published vitamin C clinical trials in COVID-19 patients. Upcoming findings from larger RCTs will provide additional evidence on vitamin supplementation in COVID-19 patients.


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