A wet-bulb temperature of 35°C has been theorized to be the limit to human adaptability to extreme heat, a growing concern in the face of continued and predicted accelerated climate change. While this theorized threshold is based in physiological principles it has not been tested using empirical data. This study examined the critical wet-bulb temperature (Twb, crit) at which heat stress becomes uncompensable in young, healthy adults performing tasks at modest metabolic rates mimicking basic activities of daily life. Across six experimentally determined environmental limits, no subject's Twb, crit reached the 35°C limit and all means were significantly lower than the theoretical 35°C threshold. Mean Twb, crit values were relatively constant across 36-40°C humid environments and averaged 30.55±0.98 °C but progressively decreased (higher deviation from 35°C) in hotter, dry ambient environments. Twb, crit was significantly associated with mean skin temperature (and a faster warming rate of the skin) due to larger increases in dry heat gain in the hot-dry environments. As sweat rates did not significantly differ among experimental environments, evaporative cooling was outpaced by dry heat gain in hot-dry conditions, causing larger deviations from the theoretical 35°C adaptability threshold. In summary, a wet-bulb temperature threshold cannot be applied to human adaptability across all climatic conditions and where appropriate (high humidity), that threshold is well below 35°C.